Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jarda T. Wroblewski"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(1)
Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdbd847a0c2b37ae6379be55f05abbc
https://pubmed.ncbi.nlm.nih.gov/30054311
https://pubmed.ncbi.nlm.nih.gov/30054311
Autor:
Sergey Pshenichkin, Carrie Bowman Dalley, Hannah A. Hathaway, Ewa Grajkowska, Jarda T. Wroblewski, Tara Gelb, Barry B. Wolfe
Publikováno v:
Biochemical Pharmacology. 98:182-189
The metabotropic glutamate 1 (mGlu1) receptor has emerged as a novel target for the treatment of metastatic melanoma and various other cancers. Our laboratory has demonstrated that a selective, non-competitive mGlu1 receptor antagonist slows human me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a9c018c66d32cc46901eec2941450a
https://doi.org/10.1016/j.bcp.2015.08.091
https://doi.org/10.1016/j.bcp.2015.08.091
Autor:
Jarda T. Wroblewski, Eric J. Miller, Ewa Grajkowska, Carrie Bowman-Dalley, Dennis C. Liotta, Barry B. Wolfe, Barbara Wroblewska, Monica Javidnia, John O. DiRaddo
Publikováno v:
Molecular Pharmacology. 88:450-459
The elemental anion chloride is generally considered a passive participant in neuronal excitability, and has never been shown to function as an agonist in its own right. We show that the antagonist-mediated, glutamate-independent inverse agonism of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab4b75a3f48a8deb76826ae891a5d78
https://doi.org/10.1124/mol.114.096420
https://doi.org/10.1124/mol.114.096420
Autor:
Sergey Pshenichkin, Barry B. Wolfe, Andrew C. Emery, Ewa Grajkowska, Tara Gelb, Hannah A. Hathaway, Jarda T. Wroblewski
Publikováno v:
Neuropharmacology. 93:199-208
The majority of existing research on the function of metabotropic glutamate (mGlu) receptor 1 focuses on G protein-mediated outcomes. However, similar to other G protein-coupled receptors (GPCR), it is becoming apparent that mGlu1 receptor signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3544122b767a6893729591b1c0b1d4d6
https://doi.org/10.1016/j.neuropharm.2015.02.007
https://doi.org/10.1016/j.neuropharm.2015.02.007
Autor:
Hannah A. Hathaway, Jarda T. Wroblewski, Eric C. Miller, Barry B. Wolfe, Andrew C. Emery, Sergey Pshenichkin, Ewa Grajkowska, Robert P. Yasuda, John O. DiRaddo, Guy Rodrigue Takoudjou
Publikováno v:
Molecular Pharmacology. 82:291-301
The metabotropic glutamate 1a (mGlu1a) receptor is a G protein-coupled receptor linked with phosphoinositide (PI) hydrolysis and with β-arrestin-1-mediated sustained extracellular signal-regulated kinase (ERK) phosphorylation and cytoprotective sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa75742c144f5405a5a9d7f89d3a3c6
https://doi.org/10.1124/mol.112.078444
https://doi.org/10.1124/mol.112.078444
Autor:
Ewa Grajkowska, Gilles Tamagnan, Jarda T. Wroblewski, Bryan L. Roth, David Alagille, Ronald M. Baldwin
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:197-209
Noncompetitive antagonists of the human metabotropic glutamate receptor subtype 5 (mGluR5) have been implicated as potential therapeutics for the treatment of a variety of nervous system disorders, including pain, anxiety, and drug addiction. To disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9634a0f50291b7201321808b2a4b056e
https://doi.org/10.1016/j.bmc.2004.09.042
https://doi.org/10.1016/j.bmc.2004.09.042
Autor:
Jia Zhou, Alan P. Kozikowski, Barbara Wroblewska, Tatsuo Yamamoto, Joseph H. Neale, Serabi Hirasawa, Jarda T. Wroblewski, Ewa Grajkowska
Publikováno v:
European Journal of Neuroscience. 20:483-494
The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) acts as an agonist at group II metabotropic glutamate receptors (mGluRs). NAAG is inactivated by extracellular peptidase activity yielding glutamate and N-acetylaspartate. We recently deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046bd2f7d295714e005304308526521b
https://doi.org/10.1111/j.1460-9568.2004.03504.x
https://doi.org/10.1111/j.1460-9568.2004.03504.x
Autor:
Joseph H. Neale, Alan P. Kozikowski, Fajun Nan, Jiazhong Zhang, Barbara Wroblewska, Tomasz Bzdega, Ewa Grajkowska, Pavel A. Petukhov, Tatsuo Yamamoto, Jarda T. Wroblewski
Publikováno v:
Journal of Medicinal Chemistry. 47:1729-1738
The neuropeptidase glutamate carboxypeptidase II (GCPII) hydrolyzes N-acetyl-L-aspartyl-L-glutamate (NAAG) to liberate N-acetylaspartate and glutamate. GCPII was originally cloned as PSMA, an M(r) 100,000 type II transmembrane glycoprotein highly exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d3bd04e908592fbd0959871b3d17ca
https://doi.org/10.1021/jm0306226
https://doi.org/10.1021/jm0306226
Autor:
Jason E. Savage, Paul Ernsberger, Qi Shi, Sandra J. Hufeisen, Joseph H. Nadeau, Ewa Grajkowska, Jarda T. Wroblewski, Bryan L. Roth, Laura Rauser
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:131-142
Moderate hyperhomocysteinemia is associated with several diseases, including coronary artery disease, stroke, Alzheimer's disease, schizophrenia, and spina bifida. However, the mechanisms for their pathogenesis are unknown but could involve the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18e0fcca302d89b6c65a21e0d8f19e2
https://doi.org/10.1124/jpet.102.047092
https://doi.org/10.1124/jpet.102.047092
Publikováno v:
Journal of Neurochemistry. 63:1207-1217
Cerebellar granule neurons in primary culture express metabotropic glutamate receptors (mGluRs) coupled to the stimulation of phosphoinositide hydrolysis and to the inhibition of cyclic AMP (cAMP) formation. To evaluate which mGluR mRNAs are expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c912b90c3b53d373c676734bbe7f38f
https://doi.org/10.1046/j.1471-4159.1994.63041207.x
https://doi.org/10.1046/j.1471-4159.1994.63041207.x