Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jaqueline A.M. Smith"'
Abstract B108: 4EBP3 mRNA as a biomarker of therapeutic response to treatment with mTORC1 inhibitors
Autor:
Bianca J. Lee, Ed Lorenzana, Mallika Singh, Robert J. Nichols, Jaqueline A.M. Smith, Stacy L. Wilson, James B. Aggen, Nuntana Dinglasan, G. Leslie Burnett, David Wildes, Tram Nguyen
Publikováno v:
Molecular Cancer Therapeutics. 18:B108-B108
Aberrantly activated PI3K/mTOR signaling is frequently implicated as an oncogenic driver in human cancer. In response to nutrient and growth factor stimuli, mTOR complex 1 (mTORC1) regulates cell growth and cap-dependent protein translation through p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8d42869a21897a554970e627e1064ee
https://doi.org/10.1158/1535-7163.targ-19-b108
https://doi.org/10.1158/1535-7163.targ-19-b108
Autor:
Tomoko Ozawa, William A. Weiss, Qi-Wen Fan, Edward G. Lorenzana, James Aggen, Kevan M. Shokat, Xujun Luo, Ozlem Aksoy, Mallika Singh, Douglas R. Wassarman, Nicholas Butowski, Robin Lea, Z. H. An, Jaqueline A.M. Smith, David R. Raleigh
Publikováno v:
Neuro Oncol
Activation of phosphatidylinositol 3-kinase (PI3K)/PTEN pathway and oncogenic signaling via the mechanistic target of rapamycin (mTOR) occur in a majority of high-grade glial brain tumors. Allosteric mTOR inhibitors, such as rapamycin and other rapal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557dddab96fdef5fe6d5336f0070b240
https://doi.org/10.1093/neuonc/noz175.284
https://doi.org/10.1093/neuonc/noz175.284