Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection

Autor: Francisco J. Ibáñez, Mónica A. Farías, Angello Retamal-Díaz, Janyra A. Espinoza, Alexis M. Kalergis, Pablo A. González

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can

Externí odkaz: https://doaj.org/article/33f2fff7168941fda56ff8a7bbfaf71d

Severe respiratory disease caused by human respiratory syncytial virus impairs language learning during early infancy

Autor: Karen Bohmwald, Janyra A. Espinoza, Alexis M. Kalergis, Cristina Jara, Arturo Borzutzky, Rodrigo Hoyos-Bachiloglu, Juan Carlos Flores, Carolina Iturriaga, Javier Carcey, Mariana Medina, Marcela Peña

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

Human respiratory syncytial virus infection is a leading cause of pediatric morbidity and mortality. A previous murine study showed that during severe acute respiratory infections the virus invades the central nervous system, and that infected animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73ef9a146d54bab5b711c9375dc1e12
https://doi.org/10.1038/s41598-020-79140-1

Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection

Autor: Gisela Canedo-Marroquín, Francisco J. Salazar-Echegarai, Alexis M. Kalergis, Roberto S. Gómez, Margarita K. Lay, Sebastián A. Riquelme, Janyra A. Espinoza, Ignacio Anegon, Phillipe Blancou, Pablo A. González, Thomas Simon, Miguel A. León, Susan M. Bueno, Pablo F. Céspedes, Claudia A. Riedel

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2017, 199 (1), pp.212-223. ⟨10.4049/jimmunol.1601414⟩
Journal Of Immunology
Artículos CONICYT
CONICYT Chile
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Journal of Immunology, 2017, 199 (1), pp.212-223. ⟨10.4049/jimmunol.1601414⟩

Human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory tract infections in children. The development of novel prophylactic and therapeutic antiviral drugs against hRSV is imperative to control the burden of disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba94635a92b9d78cefb5802f786cdc6
https://doi.org/10.4049/jimmunol.1601414

Is there an effect of environmental temperature on the response to an antigen and the metabolic rate in pups of the rodent Octodon degus?

Autor: Alexis M. Kalergis, Janyra A. Espinoza, Natalia Ramirez-Otarola, Pablo Sabat

Publikováno v: Journal of thermal biology. 71

Environmental temperature is a variable that influences all aspects of organisms, from physiological, e.g. immune function, and morphological traits to behavior. Recent studies have reported that environmental temperature modulates organisms' thermor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3beb735a10621fb357f5a77d93fbbe3
https://pubmed.ncbi.nlm.nih.gov/29301686

Themis, the new kid on the block for t-cell development

Autor: Janyra A. Espinoza, Alexis M. Kalergis, Evelyn L. Jara

Publikováno v: Cellular & Molecular Immunology
Artículos CONICYT
CONICYT Chile
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Understanding T-cell development is a major goal of the immunology field and is crucial for the elucidation of the mechanisms behind self-tolerance and the occurrence of autoimmune disorders. T-cell development is a complex process that begins in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270e771c8de7b5a14d0759b06059419f