A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy.

Autor: Chantal Beekman, Jessica A Sipkens, Janwillem Testerink, Stavros Giannakopoulos, Dyonne Kreuger, Judith C van Deutekom, Giles V Campion, Sjef J de Kimpe, Afrodite Lourbakos

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107494 (2014)

Duchenne muscular dystrophy (DMD) is characterized by the absence or reduced levels of dystrophin expression on the inner surface of the sarcolemmal membrane of muscle fibers. Clinical development of therapeutic approaches aiming to increase dystroph

Externí odkaz: https://doaj.org/article/cd13d08f1d8d4544abd4ec444d29d804

Using a State-of-the-Art Toolbox to Evaluate Molecular and Functional Readouts of Antisense Oligonucleotide-Induced Exon Skipping in

Autor: Rani van den Eijnde, Jukka Puoliväli, Anneke A.M. Janson, Toni Ahtoniemi, Janwillem Testerink, Nicole A. Datson, Kimmo Lehtimäki, Suzanne Bijl, Judith C.T. van Deutekom, Rudie Weij, Timo Bragge

Publikováno v: Nucleic Acid Therapeutics

Duchenne muscular dystrophy (DMD) is a severe childhood muscle disease primarily caused by the lack of functional dystrophin at the muscle fiber membranes. Multiple therapeutic approaches are currently in (pre)clinical development, aimed at restoring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f2b225baf73b85e079edc2c98b361c
https://pubmed.ncbi.nlm.nih.gov/31821107

Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts

Autor: Sjoerd A.A. van den Berg, Jelani T. D. Leito, Frans Witte, Richard T. Jaspers, Ines J. Marques, Herman P. Spaink, Christoph P. Bagowski, Janwillem Testerink

Publikováno v: Marques, I J, Leito, J T D, Spaink, H P, Testerink, J, Jaspers, R T, Witte, F, van den Berg, S & Bagowski, C P 2008, ' Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts ', Journal of comparative physiology B. Biochemical, systematic and environmental physiology, vol. 178, no. 1, pp. 77-92 . https://doi.org/10.1007/s00360-007-0201-4
Marques, I J, Leito, J T, Spaink, H P, Testerink, J, Jaspers, R T, Witte, F, van den Berg, S & Bagowski, C P 2008, ' Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts ', Journal of Comparative Physiology B. Biochemical, Systemic, and Environmental Physiology, vol. 178, no. 1, pp. 77-92 . https://doi.org/10.1007/s00360-007-0201-4
Journal of comparative physiology B. Biochemical, systematic and environmental physiology, 178(1), 77-92. Springer Verlag
Journal of comparative physiology. B, Biochemical, systematic and environmental physiology, 178(1), 77-92. Springer Verlag
Journal of Comparative Physiology B. Biochemical, Systemic, and Environmental Physiology, 178(1), 77-92. Springer Verlag
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology

Insufficient blood supply during acute infarction and chronic ischemia leads to tissue hypoxia which can significantly alter gene expression patterns in the heart. In contrast to most mammals, some teleost fishes are able to adapt to extremely low ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21091f5c98f7dde431f15bfb3e93ea7
https://research.vu.nl/en/publications/dd0ecd23-4243-4e86-8746-1ffda2943f1b

P.11.21 Bioanalysis of a double blind, placebo-controlled clinical phase 2 study of drisapersen for the treatment of boys suffering from Duchenne muscular dystrophy and comparison to clinical outcome results

Autor: Stavros Giannakopoulos, J.C.T. van Deutekom, T. Holling, J. Kraus, Steve R. Hood, A. Morgan, Chantal Beekman, D. Duinsbergen, Afrodite Lourbakos, G. Campion, Janwillem Testerink, Katie Rolfe, S. de Kimpe

Publikováno v: Neuromuscular Disorders. 23:805

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder, ultimately lethal, caused by the absence of dystrophin protein due to mutations of the dystrophin gene. Drisapersen is a 2′-O-methyl-phosphothioate oligo designed to skip ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7409709a65ae9da4073fe4f43ed90746
https://doi.org/10.1016/j.nmd.2013.06.582

Differential effects of high strain and insulin-like growth factor 1 on adaptation of muscle fiber size and force

Autor: Christophe P. Bagowski, Richard T. Jaspers, Ramaswamy Krishnan, Carla Offringa, Willem J. van der Laarse, Janwillem Testerink

Publikováno v: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 153:S74

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309bad87d4077be6835a29672e1c6a6a
https://doi.org/10.1016/j.cbpa.2009.04.036