Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Janusz Z. Byczkowski"'
Autor:
Donald E. Tillitt, Kyung O. Yu, Janusz Z. Byczkowski, Stephen R. Channel, Carlyle D. Flemming, Jeffrey W. Fisher, G. Allen Burton, Joanne M. Drerup
Publikováno v:
Toxicology and Applied Pharmacology. 141:434-438
The rat hepatoma cell line, H4IIE, serves as a useful tool to assess potential biological effects such as induction of cytochrome P4501A1 expression. The objectives of this study were twofold: to investigate the kinetic time course and dosimetry of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8f91c202bd9a1e184acc1af4506036
https://doi.org/10.1006/taap.1996.0309
https://doi.org/10.1006/taap.1996.0309
Autor:
Janusz Z. Byczkowski
Publikováno v:
Drug Information Journal. 30:401-412
In this paper, a step-by-step process is described that allowed a physiologically-based pharmacokinetic (PK) model for tetrachloroethylene (PCE) for lactating mothers to be linked with the estimate...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434a27f5dca339350c5978e445c12606
https://doi.org/10.1177/009286159603000209
https://doi.org/10.1177/009286159603000209
Publikováno v:
Computer Methods and Programs in Biomedicine. 46:155-163
The risk assessment process predicts the chances of adverse health effects that the toxicant possibly can do to the target organism under expected conditions of exposure. Regulators chose among several mathematical approaches to estimate the risk, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a18c593eef39f851f34da948806c2b
https://doi.org/10.1016/0169-2607(94)01616-n
https://doi.org/10.1016/0169-2607(94)01616-n
Publikováno v:
Reproductive Toxicology. 8:307-313
Bioactivation of 14 C-benzo(a)pyrene-7,8-dihydrodiol catalyzed by lipoxygenase purified from human term placenta of nonsmoking women and intrauterine conceptal tissues (at 4 weeks of gestation) was investigated. Incubation of 14 C-benzo(a)pyrene-7,8-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c313f5343b1c74987dbbd24efb08fb98
https://doi.org/10.1016/0890-6238(94)90046-9
https://doi.org/10.1016/0890-6238(94)90046-9
Publikováno v:
International Journal of Biochemistry. 24:1691-1695
1. Regulatory properties of lipoxygenase activity in rat brain cytosol were studied using linoleic acid (LA) as a substrate. 2. A change in the absorbance at 234 nm was biphasic when a mixture of LA and pre-formed hydroperoxide (LA-OOH) was incubated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7e2d9256cab71f16c1eb3d07f4b77b
https://doi.org/10.1016/0020-711x(92)90114-g
https://doi.org/10.1016/0020-711x(92)90114-g
Autor:
Janusz Z. Byczkowski, Arun P. Kulkarni
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1125:134-141
Mechanism of lipid peroxidation triggered by vanadium in human term placental microsomes was reinvestigated in vitro. Production of lipid peroxyl radicals was estimated from co-oxygenation of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol. Vanadyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d169e91bab9c3028371417f0e54008ee
https://doi.org/10.1016/0005-2760(92)90037-v
https://doi.org/10.1016/0005-2760(92)90037-v
Autor:
Arun P. Kulkarni, Janusz Z. Byczkowski
Publikováno v:
Journal of Biochemical Toxicology. 5:139-145
Peroxidatic metabolism of benzo(a) pyrene-7,8-dihydrodiol by calcium containing extracts of rat uteri was investigated. Covalently bound and soluble metabolites of benzo(a)pyrene-7,8-dihydrodiol were quantitated by radiometry and high performance liq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f751c07b429ff454694ca9394a8e4f
https://doi.org/10.1002/jbt.2570050302
https://doi.org/10.1002/jbt.2570050302
Autor:
Janusz Z. Byczkowski
Publikováno v:
Handbook of Elemental Speciation II-Species in the Environment, Food, Medicine and Occupational Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::147ee580f0352788656ca41382972a64
https://doi.org/10.1002/0470856009.ch3c(i)
https://doi.org/10.1002/0470856009.ch3c(i)
Autor:
Janusz Z. Byczkowski
Publikováno v:
Handbook of Elemental Speciation II-Species in the Environment, Food, Medicine and Occupational Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38c2cfe0c8329cc7f23bfee105cfb7e
https://doi.org/10.1002/0470856009.ch3c
https://doi.org/10.1002/0470856009.ch3c
Publikováno v:
Toxicology and applied pharmacology. 152(2)
The use of in vitro systems in the assessment of xenobiotic metabolism has distinct advantages and disadvantages. While isolated hepatocytes and microsomes prepared from human liver may be used to generate data for comparisons among species and in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e5e081d8e839d5132baad9a09124cd
https://pubmed.ncbi.nlm.nih.gov/9853006
https://pubmed.ncbi.nlm.nih.gov/9853006