Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Janusz Rachon"'
Autor:
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Damian Flis, Justyna Budka, Iwona Inkielewicz-Stępniak, Anna Czaja, Janusz Rak, Sebastian Demkowicz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus
Externí odkaz:
https://doaj.org/article/cdb6c235654144bfbb03ab8413a8952f
Autor:
Olga Ciupak, Mateusz Daśko, Karol Biernacki, Janusz Rachon, Maciej Masłyk, Konrad Kubiński, Aleksandra Martyna, Sebastian Demkowicz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 239-248 (2021)
In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-tr
Externí odkaz:
https://doaj.org/article/1d8fdeadde00449b96ff653055b93fa6
Autor:
Mateusz Daśko, Sebastian Demkowicz, Karol Biernacki, Olga Ciupak, Witold Kozak, Maciej Masłyk, Janusz Rachon
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1163-1184 (2020)
The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulphatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including oestrogens and androgens) and
Externí odkaz:
https://doaj.org/article/f089a2247d0c42ee9b6e9c28a518045c
Autor:
Mateusz Daśko, Anna Dołęga, Magdalena Siedzielnik, Karol Biernacki, Olga Ciupak, Janusz Rachon, Sebastian Demkowicz
Publikováno v:
Molecules, Vol 26, Iss 13, p 4059 (2021)
Herein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic of steroids in the drug development process.
Externí odkaz:
https://doaj.org/article/aed464f0ec7e4020bc5648ce1c254479
Autor:
Karol Biernacki, Mateusz Daśko, Olga Ciupak, Konrad Kubiński, Janusz Rachon, Sebastian Demkowicz
Publikováno v:
Pharmaceuticals, Vol 13, Iss 6, p 111 (2020)
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development
Externí odkaz:
https://doaj.org/article/9781be4164914d6fbd2c951d3f7f303d
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 4, Pp o856-o856 (2010)
The title compound, C6H13O3PSe, was obtained in the reaction of 5,5-dimethyl-2-oxo-2-seleno-1,3,2-dioxaphosphorinane potassium salt with methyl iodide. The selenomethyl group is in the axial position in relation to the six-membered dioxaphosphorinane
Externí odkaz:
https://doaj.org/article/08143914bc4d422692b1ec218a004421
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o855-o855 (2009)
The title compound, C19H14ClO2PSe, was obtained in the reaction of the diphenylmonoselenophosphinic acid ammonium salt with 4-chlorobenzoyl chloride. The dihedral angle between the P-bonded aromatic rings is 72.64 (14)°. Packing of the molecules in
Externí odkaz:
https://doaj.org/article/3d8449e023084e5ca6a79e1ecbeba6af
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 4, Pp o853-o854 (2009)
The title compound, C17H19O2PSe, was obtained in the reaction of the diphenylmonoselenophosphinic acid ammonium salt with pivaloyl chloride. The P—Se bond length of 2.0769 (11) Å is normal, while the P—O bond length of 1.650 (3) Å is longer tha
Externí odkaz:
https://doaj.org/article/6300e4ba06c842d5a826fa736723de8e
Autor:
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Witold Kozak, Janusz Rak, Konrad Kubiński, Maciej Masłyk, Aleksandra Martyna, Magdalena Śliwka-Kaszyńska, Joanna Wietrzyk, Marta Świtalska, Alessio Nocentini, Claudiu T. Supuran, Sebastian Demkowicz
Publikováno v:
Journal of Medicinal Chemistry. 65:5044-5056
Autor:
Janusz Rachon, Konrad Kubiński, Aleksandra Martyna, Mateusz Daśko, Maciej Masłyk, Olga Ciupak, Sebastian Demkowicz, Karol Biernacki
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 239-248 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-tr