Zobrazeno 1 - 10
of 379
pro vyhledávání: '"Janusz M Bujnicki"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1009783 (2022)
Computational methods play a pivotal role in drug discovery and are widely applied in virtual screening, structure optimization, and compound activity profiling. Over the last decades, almost all the attention in medicinal chemistry has been directed
Externí odkaz:
https://doaj.org/article/6cbd49b2c37344c7a5bbee1e99d33373
Autor:
Filip Stefaniak, Janusz M Bujnicki
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008309 (2021)
RNA is considered as an attractive target for new small molecule drugs. Designing active compounds can be facilitated by computational modeling. Most of the available tools developed for these prediction purposes, such as molecular docking or scoring
Externí odkaz:
https://doaj.org/article/f2fcf9bfc31b45078288850de40830cb
Autor:
Martyna Nowacka, Humberto Fernandes, Agnieszka Kiliszek, Agata Bernat, Grzegorz Lach, Janusz M Bujnicki
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214481 (2019)
The bacteriophage Mu Com is a small zinc finger protein that binds to its cognate mom mRNA and activates its translation. The Mom protein, in turn, elicits a chemical modification (momification) of the bacteriophage genome, rendering the DNA resistan
Externí odkaz:
https://doaj.org/article/289e02ccae954e0ba1d290a1bf9ab5de
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0217913 (2019)
Cellular DNA is daily exposed to several damaging agents causing a plethora of DNA lesions. As a first aid to restore DNA integrity, several enzymes got specialized in damage recognition and lesion removal during the process called base excision repa
Externí odkaz:
https://doaj.org/article/907a04ec5ac94c128262365ec1c7d9e4
Autor:
Edis Dzananovic, Astha, Grzegorz Chojnowski, Soumya Deo, Evan P Booy, Pauline Padilla-Meier, Kevin McEleney, Janusz M Bujnicki, Trushar R Patel, Sean A McKenna
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186849 (2017)
Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, phosphorylates eukaryotic initiat
Externí odkaz:
https://doaj.org/article/84fd847862b04e2c823b1f4366e567eb
Autor:
Sunbin Liu, Sina Mozaffari-Jovin, Jan Wollenhaupt, Karine F Santos, Matthias Theuser, Stanislaw Dunin-Horkawicz, Patrizia Fabrizio, Janusz M Bujnicki, Reinhard Lührmann, Markus C Wahl
Publikováno v:
eLife, Vol 4 (2015)
Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding
Externí odkaz:
https://doaj.org/article/3b0881cfdd874157b3987c784fcd7a22
Autor:
Magdalena Plotka, Anna-Karina Kaczorowska, Agnieszka Morzywolek, Joanna Makowska, Lukasz P Kozlowski, Audur Thorisdottir, Sigurlaug Skírnisdottir, Sigridur Hjörleifsdottir, Olafur H Fridjonsson, Gudmundur O Hreggvidsson, Jakob K Kristjansson, Slawomir Dabrowski, Janusz M Bujnicki, Tadeusz Kaczorowski
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137374 (2015)
Phage vB_Tsc2631 infects the extremophilic bacterium Thermus scotoductus MAT2631 and uses the Ts2631 endolysin for the release of its progeny. The Ts2631 endolysin is the first endolysin from thermophilic bacteriophage with an experimentally validate
Externí odkaz:
https://doaj.org/article/734d8df59d314e428d9b7a517b8804c0
Autor:
Anna D Grabowska, Ewa Wywiał, Stanislaw Dunin-Horkawicz, Anna M Łasica, Marc M S M Wösten, Anna Nagy-Staroń, Renata Godlewska, Katarzyna Bocian-Ostrzycka, Katarzyna Pieńkowska, Paweł Łaniewski, Janusz M Bujnicki, Jos P M van Putten, E Katarzyna Jagusztyn-Krynicka
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106247 (2014)
BackgroundBacterial Dsb enzymes are involved in the oxidative folding of many proteins, through the formation of disulfide bonds between their cysteine residues. The Dsb protein network has been well characterized in cells of the model microorganism
Externí odkaz:
https://doaj.org/article/609ae1e86bf142ebae9cc4a71fdcee8b
Autor:
Agata P. Perlinska, Mai Lan Nguyen, Smita P. Pilla, Emilia Staszor, Iwona Lewandowska, Agata Bernat, Elżbieta Purta, Rafal Augustyniak, Janusz M. Bujnicki, Joanna I. Sulkowska
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
We have been aware of the existence of knotted proteins for over 30 years—but it is hard to predict what is the most complicated knot that can be formed in proteins. Here, we show new and the most complex knotted topologies recorded to date—doubl
Externí odkaz:
https://doaj.org/article/00796d098d6c4af09d78c454d2c03937
Autor:
Janusz M Bujnicki, Jerzy Tiuryn
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003048 (2013)
Externí odkaz:
https://doaj.org/article/1619aa56c9534ee286581792b8e7fdbc