Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Janusz Frackowiak"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Autism spectrum disorder (ASD) is associated with enhanced processing of amyloid-β precursor protein (APP) by secretase-α, higher blood levels of sAPPα and intraneuronal accumulation of N-terminally truncated Aβ peptides in the brain cortex — m
Externí odkaz:
https://doaj.org/article/5c26eb41e06548239d0c9810e7bf1339
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Autism, the most frequent neurodevelopmental disorder of a very complex etiopathology, is associated with dysregulation of cellular homeostatic mechanisms, including processing of amyloid-β precursor protein (APP). Products of APP processin
Externí odkaz:
https://doaj.org/article/3fb4af968fba44608f242dd8b5af35f6
Autor:
Jerzy Wegiel, Janusz Frackowiak, Bozena Mazur-Kolecka, N Carolyn Schanen, Edwin H Cook, Marian Sigman, W Ted Brown, Izabela Kuchna, Jarek Wegiel, Krzysztof Nowicki, Humi Imaki, Shuang Yong Ma, Abha Chauhan, Ved Chauhan, David L Miller, Pankaj D Mehta, Michael Flory, Ira L Cohen, Eric London, Barry Reisberg, Mony J de Leon, Thomas Wisniewski
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35414 (2012)
BackgroundIt has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type-specific amount.Methodology/principal finding
Externí odkaz:
https://doaj.org/article/b0b05bdd307f40cfa10a399a7b5dca21
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Autism, the most frequent neurodevelopmental disorder of a very complex etiopathology, is associated with dysregulation of cellular homeostatic mechanisms, including processing of amyloid-β precursor protein (APP). Products of APP processing — N-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bee79197cf5c25471fc1538219b460
https://doi.org/10.1186/s40478-020-00923-8
https://doi.org/10.1186/s40478-020-00923-8
Autor:
Thomas Wisniewski, Pankaj Mehta, Bruce A. Patrick, Sangita P. Mehta, David Miller, Bozena Mazur-Kolecka, Marc Barshatzky, Jerzy Wegiel, Janusz Frackowiak
Publikováno v:
Journal of Alzheimer's disease : JAD. 62(4)
N-terminally truncated pyroglutamate amyloid-β (Aβ) peptide starting at position 3 represents a significant fraction of Aβ peptides (pE3-Aβ) in amyloid plaques of postmortem brains from patients with Alzheimer's disease (AD) and older persons wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0ff40b3a2ce78e1a8b15eb270564b9
https://pubmed.ncbi.nlm.nih.gov/29504532
https://pubmed.ncbi.nlm.nih.gov/29504532
Autor:
Holger Patzke, Lori Hrdlicka, Emily A. Freeman, Janusz Frackowiak, Marc Barshatzky, Pankaj Mehta, Jean-Francois Blain, Sangita P. Mehta, David Miller, Bruce A. Patrick, Jerzy Wegiel, Bozena Mazur-Kolecka
Publikováno v:
Journal of Alzheimer's disease : JAD. 57(1)
Secreted soluble amyloid-β 1-37 (Aβ37) peptide is one of the prominent Aβ forms next to Aβ40, and is found in cerebrospinal fluid (CSF) and blood. Recent studies have shown the importance of quantitation of CSF Aβ37 levels in combination with A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310b6d437fad322e65eccfdc7daca5a
https://pubmed.ncbi.nlm.nih.gov/28222530
https://pubmed.ncbi.nlm.nih.gov/28222530
Autor:
Janusz Frackowiak, W. Ted Brown, Edmund C. Jenkins, Michael Flory, Wojciech Kaczmarski, Ira L. Cohen, Bozena Mazur-Kolecka, Maripaz G. Gonzalez
Publikováno v:
Brain and Development. 36:322-329
The pathological role of autoantibodies in development of CNS disorders is a new idea with growing interest among neuroscientists. The involvement of autoimmune response in the pathogenesis of autism spectrum disorders (ASD) has been suggested by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0d9900928d86c068e471d831751161
https://doi.org/10.1016/j.braindev.2013.04.015
https://doi.org/10.1016/j.braindev.2013.04.015
Autor:
Pankaj Mehta, David Miller, Marc Barshatzky, Sangitta Mehta, Janusz Frackowiak, Bozena Mazur-Kolecka, Jerzy Wegiel, Bruce A. Patrick
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54fdeeaedf2589b2fc629b1091f18581
https://doi.org/10.1016/j.jalz.2016.06.1837
https://doi.org/10.1016/j.jalz.2016.06.1837
Autor:
Yu-Wen Hwang, Elizabeth Kida, Ausma Rabe, Adam A. Golabek, Tatyana Adayev, Janusz Frackowiak, Michael Flory, Wojciech Kaczmarski, Bozena Mazur-Kolecka, Elaine Marchi, Jerzy Wegiel
Publikováno v:
Journal of Neuroscience Research. 90:999-1010
Overexpression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A), encoded by a gene located in the Down syndrome (DS) critical region, is considered a major contributor to developmental abnormalities in DS. DYRK1A regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd889994d8567acb5f5c3039098f8022
https://doi.org/10.1002/jnr.23007
https://doi.org/10.1002/jnr.23007
Autor:
Tatyana Adayev, Thomas Wisniewski, Wayne Silverman, Arthur J. Dalton, Khalid Iqbal, Kuo-Chiang Wang, Barry Reisberg, Fei Liu, Wojciech Kaczmarski, Shuang Yang Ma, Izabela Kuchna, Yu-Wen Hwang, Isabel Monteiro, Mony J. de Leon, Bozena Mazur-Kolecka, Jarek Wegiel, Inge-Grundke Iqbal, Cheng-Xin Gong, Janusz Frackowiak, Madhabi Barua, Krzysztof Nowicki, Florence Lai, Jerzy Wegiel
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 70:36-50
Triplication of chromosome 21 in Down syndrome (DS) results in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein and appears in intrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817d8f3282943bdec6d0c467bb117ec9
https://doi.org/10.1097/nen.0b013e318202bfa1
https://doi.org/10.1097/nen.0b013e318202bfa1