Výsledky vyhledávání - "Janusz B, Suszkiw"

Presynaptic Disruption of Transmitter Release by Lead

Autor: Janusz B. Suszkiw

Publikováno v: NeuroToxicology. 25:599-604

Low concentrations of inorganic lead ions (Pb2+) disrupt transmitter release by causing aberrant augmentation of spontaneous and suppression of evoked release. These effects result from high affinity interactions of Pb2+ with the voltage-gated calciu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e45f8e1dc3f051c657fb7e3524e05d
https://doi.org/10.1016/j.neuro.2003.09.009

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Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure

Autor: Janusz B. Suszkiw, Mingfu Zhou

Publikováno v: Brain Research. 999:142-147

Maternally lead (Pb)-exposed, juvenile rats exhibit significant deficits in spatial reference memory acquisition and working memory performance in the Morris water maze (MWM). Acute systemic application of nicotine reverses these deficits without aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bea2629571dc4b5a995c76dd031c98
https://doi.org/10.1016/j.brainres.2003.10.068

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Upregulation of Tyrosine Hydroxylase and Downregulation of Choline Acetyltransferase in Lead-Exposed PC12 Cells: The Role of PKC Activation

Autor: Xiaoyan Sun, Janusz B. Suszkiw, Xintian Tian

Publikováno v: Toxicology and Applied Pharmacology. 167:246-252

The effects of lead (Pb) on the expression of tyrosine hydroxylase (TH) and choline acetyltransferase (ChAT) were compared in relation to Pb-activation of cPKC in the PC12 cells. Exposure to 0.53 microM Pb (0.1094 ppm) increased TH but reduced ChAT a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666740dc4256200df25424fdb6238aa4
https://doi.org/10.1006/taap.2000.8996

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Symposium Overview: Chemical Modulation of Neuroreceptors and Channels via Intracellular Components

Autor: William D. Atchison, Vjekoslav Miletic, Toshio Narahashi, Steven N. Treistman, Janusz B. Suszkiw

Publikováno v: Toxicological Sciences. 45:9-25

Whereas the roles of G proteins and protein kinases in various neuroreceptors and ion channels have been studied extensively, their roles in the actions of drugs and toxicants on these receptors and channels remain to be elucidated. Almost all drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a468859de70c6d7161434e202ecde76
https://doi.org/10.1006/toxs.1998.2435

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Reduced densities of sodium-dependent [3H] hemicholinium-3 binding sites in hippocampus of developmental rats following perinatal low-level lead exposure

Autor: Janusz B. Suszkiw, X. Tian, H. Bielarczyk, N. Bourjeily

Publikováno v: Developmental Brain Research. 86:268-274

We investigated the effect of perinatal, low-level lead exposure on [3H]hemicholinium-3 (HC-3) binding in the hippocampus of postnatal rat. Rat pups were maternally lead-exposed from gestational day 16 through postnatal day 28 (PN28). In control anim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbf66eb41b26a55b0c2a55dfcb1ec91
https://doi.org/10.1016/0165-3806(95)00038-f

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Contributors

Autor: Francisco J. Alvarez-Leefmans, Clive M. Baumgarten, Kenneth M. Blumenthal, John H.B. Bridge, Bruce A. Carlson, Laura Conforti, John R. Dedman, Neil D. Detweiler, Istvan Edes, Robert A. Farley, Joseph J. Feher, Darrell Fleischman, Michael S. Forbes, Kenneth W. Foster, Jeffrey C. Freedman, Andrew S. French, Nicole Gallo-Payet, Hugo Gonzalez-Serratos, Anthony L. Gotter, Michael S. Grace, Steven M. Grassl, Dennis W. Grogan, J. Woodland Hastings, Judith Heiny, Aldebaran M. Hofer, Atsushi Inanobe, Marcia A. Kaetzel, Robert S. Kass, Sujay V. Kharade, Takeshi Kobayashi, Evangelia G. Kranias, Yoshihisa Kurachi, Stephen Lambert, Michael Levandowsky, Simon Rock Levinson, Daniel C. Marcus, Gerhard Meissner, Stan Misler, Catherine E. Morris, Michela Ottolia, Richard J. Paul, Asif R. Pathan, Marcel Daniel Payet, Matthew Pincus, Tracy J. Pritchard, Robert W. Putnam, Seth Robey, Stephen D. Roper, Nancy J. Rusch, Kevin J. Sampson, William A. Sather, Nicholas Sperelakis, Anup K. Srivastava, Janusz B. Suszkiw, Timothy C. Tricas, Noritsugu Tohse, Päivi H. Torkkeli, Natalia S. Torres, Kenneth R. Tovar, Richard D. Veenstra, Gordon M. Wahler, Gary L. Westbrook, Hisashi Yokoshiki, Anita L. Zimmerman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::667c1f199fb972124f1a7a9d128ec8fb
https://doi.org/10.1016/b978-0-12-387738-3.01002-7

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Intracellular mechanism of Pb(2+)-induced norepinephrine release from bovine chromaffin cells

Autor: Janusz B. Suszkiw, J. L. Tomsig

Publikováno v: American Journal of Physiology-Cell Physiology. 265:C1630-C1636

The intracellular mechanism of Pb(2+)-induced release of norepinephrine (NE) was investigated in comparison with Ca2+ in bovine chromaffin cells permeabilized with staphylococcal alpha-toxin. Pb2+ activated NE release at considerably lower concentrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9961edac7f48a7866bd7ba14f6952477
https://doi.org/10.1152/ajpcell.1993.265.6.c1630

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Electrophysiological properties of early postnatal rat septal neurons in short-term culture

Autor: Janusz B. Suszkiw, A.E. Schaffner, J.L. Barker

Publikováno v: Brain Research. 588:246-254

Electrophysiological properties of septal neurons dissociated from PN1-PN7 rats were examined between 1 and 5 days in vitro (DIV) with whole-cell patch-clamp recording. The neurons had RMPs in the range -40 to -80 mV, resistances 0.5-1.5 G omega, and

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https://doi.org/10.1016/0006-8993(92)91582-y

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Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells

Autor: Janusz B. Suszkiw, JoséL. Tomsig

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1069:197-200

Fura-2 was used to monitor Pb2+ entry into isolated bovine chromaffin cells exposed to micromolar concentrations of Pb2+ in media containing basal or high concentrations of K+. The entry of Pb2+ consists of voltage-independent and voltage-dependent (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfddecf450cf9cb0961ace3d6e65ea4a
https://doi.org/10.1016/0005-2736(91)90124-q

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Effects of lead on cholinergic SN56 neuroblastoma cells

Autor: Agnieszka, Jankowska-Kulawy, Sylwia, Gul-Hinc, Hanna, Bielarczyk, Janusz B, Suszkiw, Tadeusz, Pawełczyk, Aleksandra, Dyś, Andrzej, Szutowicz

Publikováno v: Acta neurobiologiae experimentalis. 68(4)

Age-dependent accumulation of lead in brain has been implicated in the pathomechanisms of Alzheimer's disease. The aim of this work was to investigate whether cholinotoxic effects of lead may result from alterations in acetyl-CoA metabolism. One day

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https://pubmed.ncbi.nlm.nih.gov/19112468

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