Výsledky vyhledávání - "Janus Schou Jakobsen"

Akademický článek

Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation

Autor: Kim Theilgaard-Mönch, Sachin Pundhir, Kristian Reckzeh, Jinyu Su, Marta Tapia, Benjamin Furtwängler, Johan Jendholm, Janus Schou Jakobsen, Marie Sigurd Hasemann, Kasper Jermiin Knudsen, Jack Bernard Cowland, Anna Fossum, Erwin Schoof, Mikkel Bruhn Schuster, Bo T. Porse

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Here the authors show that differentiation of haematopoietic stem cells into mature blood cells is primed by cell type-specific transcription factors at the enhancer level during early differentiation, before they confere promoter-driven growth arres

Externí odkaz: https://doaj.org/article/c8be37de68644952b82321d25c3ff0a5

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Akademický článek

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

Autor: Sachin Pundhir, Felicia Kathrine Bratt Lauridsen, Mikkel Bruhn Schuster, Janus Schou Jakobsen, Ying Ge, Erwin Marten Schoof, Nicolas Rapin, Johannes Waage, Marie Sigurd Hasemann, Bo Torben Porse

Publikováno v: Cell Reports, Vol 23, Iss 9, Pp 2744-2757 (2018)

Transcription factors PU.1 and CEBPA are required for the proper coordination of enhancer activity during granulocytic-monocytic (GM) lineage differentiation to form myeloid cells. However, precisely how these factors control the chronology of enhanc

Externí odkaz: https://doaj.org/article/74d05141e55d44a59483320ad28f0b2a

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H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

Autor: Anne Meldgaard Hansen, Ying Ge, Mikkel Bruhn Schuster, Sachin Pundhir, Janus Schou Jakobsen, Adrija Kalvisa, Marta Cecylia Tapia, Sandra Gordon, Francesca Ambri, Frederik Otzen Bagger, Deo Pandey, Kristian Helin, Bo Torben Porse

Publikováno v: Science Advances. 8

Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3–9 homolog 1 (SUV39H1) is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923df6bd828dac7cf3621df59daa10e6
https://doi.org/10.1126/sciadv.abf8627

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Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard

Publikováno v: Theilgaard-Monch, K, Pundhir, S, Reckzeh, K, Su, J, Tapia, M, Furtwangler, B, Jendholm, J, Jakobsen, J S, Hasemann, M S, Knudsen, K J, Cowland, J B, Fossum, A, Schoof, E, Schuster, M B & Porse, B T 2022, ' Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation: In memoriam Professor Niels Borregaard ', Nature Communications, vol. 13, 3595 . https://doi.org/10.1038/s41467-022-31332-1
Theilgaard-Mönch, K, Pundhir, S, Reckzeh, K, Su, J, Tapia, M, Furtwängler, B, Jendholm, J, Jakobsen, J S, Hasemann, M S, Knudsen, K J, Cowland, J B, Fossum, A, Schoof, E, Schuster, M B & Porse, B T 2022, ' Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation : In memoriam Professor Niels Borregaard ', Nature Communications, vol. 13, no. 1, 3595 . https://doi.org/10.1038/s41467-022-31332-1

Differentiation of multipotent stem cells into mature cells is fundamental for development and homeostasis of mammalian tissues, and requires the coordinated induction of lineage-specific transcriptional programs and cell cycle withdrawal. To underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85599e0683081b4f0f2a88e7bea8f2c
https://pubmed.ncbi.nlm.nih.gov/35739121

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