Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Janus S. Jakobsen"'
Autor:
Marie S Hasemann, Felicia K B Lauridsen, Johannes Waage, Janus S Jakobsen, Anne-Katrine Frank, Mikkel B Schuster, Nicolas Rapin, Frederik O Bagger, Philipp S Hoppe, Timm Schroeder, Bo T Porse
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004079 (2014)
Transcription factors are key regulators of hematopoietic stem cells (HSCs) and act through their ability to bind DNA and impact on gene transcription. Their functions are interpreted in the complex landscape of chromatin, but current knowledge on ho
Externí odkaz:
https://doaj.org/article/cd6fa19cee4f46d1a7dc8f2a86cd50fa
Autor:
Bo T. Porse, Mikkel Bruhn Schuster, Johannes Waage, Nicolas Rapin, Sachin Pundhir, Erwin M. Schoof, Felicia Kathrine Bratt Lauridsen, Janus S. Jakobsen, Ying Ge, Marie Sigurd Hasemann
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2744-2757 (2018)
Pundhir, S, Bratt Lauridsen, F K, Schuster, M B, Jakobsen, J S, Ge, Y, Schoof, E M, Rapin, N P J-P, Waage, J, Hasemann, M S & Porse, B T 2018, ' Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors ', Cell Reports, vol. 23, no. 9, pp. 2744-2757 . https://doi.org/10.1016/j.celrep.2018.05.012
Pundhir, S, Bratt Lauridsen, F K, Schuster, M B, Jakobsen, J S, Ge, Y, Schoof, E M, Rapin, N P J-P, Waage, J, Hasemann, M S & Porse, B T 2018, ' Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors ', Cell Reports, vol. 23, no. 9, pp. 2744-2757 . https://doi.org/10.1016/j.celrep.2018.05.012
Transcription factors PU.1 and CEBPA are required for the proper coordination of enhancer activity during granulocytic-monocytic (GM) lineage differentiation to form myeloid cells. However, precisely how these factors control the chronology of enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c291d8a8d938b0b3ac14742facf7ac80
https://doi.org/10.1016/j.celrep.2018.05.012
https://doi.org/10.1016/j.celrep.2018.05.012
Autor:
Lina A Thoren, Gitte A Nørgaard, Joachim Weischenfeldt, Johannes Waage, Janus S Jakobsen, Inge Damgaard, Frida C Bergström, Anna M Blom, Rehannah Borup, Hanne Cathrine Bisgaard, Bo T Porse
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11650 (2010)
BackgroundNonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise from di
Externí odkaz:
https://doaj.org/article/ebbde6b63c394befb3c39ee3b7590405
Autor:
Linea Gøricke Laursen, Kristoffer Vitting-Seerup, Sachin Pundhir, Kim Theilgaard-Mönch, Janus S. Jakobsen, Mikkel Bruhn Schuster, Lars Bullinger, Coline Gentil, Peter Hokland, Nicolas Rapin, Kristian Reckzeh, Ying Ge, Jude Fitzgibbon, Teresa D'Altri, Konstanze Döhner, Bo T. Porse, Erwin M. Schoof, Johan Jendholm
Publikováno v:
Science Advances
Jakobsen, J S, Laursen, L G, Schuster, M B, Pundhir, S, Schoof, E, Ge, Y, d'Altri, T, Vitting-Seerup, K, Rapin, N, Gentil, C, Jendholm, J, Theilgaard-Mönch, K, Reckzeh, K, Bullinger, L, Döhner, K, Hokland, P, Fitzgibbon, J & Porse, B T 2019, ' Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML ', Science Advances, vol. 5, no. 7, 4304 . https://doi.org/10.1126/sciadv.aaw4304
Jakobsen, J S, Laursen, L G, Schuster, M B, Pundhir, S, Schoof, E, Ge, Y, d'Altri, T, Vitting-Seerup, K, Rapin, N, Gentil, C, Jendholm, J, Theilgaard-Mönch, K, Reckzeh, K, Bullinger, L, Döhner, K, Hokland, P, Fitzgibbon, J & Porse, B T 2019, ' Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML ', Science Advances, vol. 5, no. 7, eaaw4304, pp. 1-16 . https://doi.org/10.1126/sciadv.aaw4304
Jakobsen, J S, Laursen, L G, Schuster, M B, Pundhir, S, Schoof, E, Ge, Y, d'Altri, T, Vitting-Seerup, K, Rapin, N, Gentil, C, Jendholm, J, Theilgaard-Mönch, K, Reckzeh, K, Bullinger, L, Döhner, K, Hokland, P, Fitzgibbon, J & Porse, B T 2019, ' Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML ', Science Advances, vol. 5, no. 7, 4304 . https://doi.org/10.1126/sciadv.aaw4304
Jakobsen, J S, Laursen, L G, Schuster, M B, Pundhir, S, Schoof, E, Ge, Y, d'Altri, T, Vitting-Seerup, K, Rapin, N, Gentil, C, Jendholm, J, Theilgaard-Mönch, K, Reckzeh, K, Bullinger, L, Döhner, K, Hokland, P, Fitzgibbon, J & Porse, B T 2019, ' Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML ', Science Advances, vol. 5, no. 7, eaaw4304, pp. 1-16 . https://doi.org/10.1126/sciadv.aaw4304
In CEBPA-mutant leukemia, CEBPA up-regulates cancer-protective and -targetable CD73, indicating a novel potential therapy.
The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct mo
The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e664d2d568f0817eb9fbba2ea314177b
https://pubmed.ncbi.nlm.nih.gov/31309149
https://pubmed.ncbi.nlm.nih.gov/31309149
Autor:
Jens Vilstrup Johansen, Kathleen R. Stewart-Morgan, Cristina González-Aguilera, Nazaret Reverón-Gómez, Janus S. Jakobsen, Anja Groth, Simona Graziano, Nataliya Petryk, Constance Alabert, Valentin Flury
Publikováno v:
Molecular Cell
Reverón-Gómez, N, González-Aguilera, C, Stewart-Morgan, K R, Petryk, N, Flury, V, Graziano, S, Johansen, J V, Jakobsen, J S, Alabert, C & Groth, A 2018, ' Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication ', Molecular Cell, vol. 72, no. 2, pp. 239-249 . https://doi.org/10.1016/j.molcel.2018.08.010
Reverón-Gómez, N, González-Aguilera, C, Stewart-Morgan, K R, Petryk, N, Flury, V, Graziano, S, Johansen, J V, Jakobsen, J S, Alabert, C & Groth, A 2018, ' Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication ', Molecular Cell, vol. 72, no. 2, pp. 239-249 . https://doi.org/10.1016/j.molcel.2018.08.010
Summary Chromatin organization is disrupted genome-wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naive histones and old modified histones. It remains unknown whether the landscape of histone post-translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b87acb178840c8b35da04628d57209
Autor:
Lars Bullinger, Stefan Karlsson, Nicolas Rapin, Johannes Waage, Anton Willer, Bo T. Porse, Ewa Ohlsson, Janus S. Jakobsen, Matilda Billing
Publikováno v:
Leukemia. 29:1018-1031
Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f78ee1193ad3b677e819ca460bdfaa
https://doi.org/10.1038/leu.2014.307
https://doi.org/10.1038/leu.2014.307
Autor:
Fin Stolze Larsen, Nicolas Rapin, Janus S. Jakobsen, Johannes Waage, Bo T. Porse, Hanne Cathrine Bisgaard
Publikováno v:
Genome Research. 23:592-603
Most biological processes—such as embryonic development, differentiation, or cellular responses to external stimuli—are in essence dynamic, which requires the underlying transcriptional networks to be tightly temporally coordinated. Several large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5071804d55241eb6341d947e7b46c624
https://doi.org/10.1101/gr.146399.112
https://doi.org/10.1101/gr.146399.112
Autor:
Guillaume Valentin, Eileen E. M. Furlong, Ioannis Amarantos, Darren Gilmour, Janus S. Jakobsen, Ya Hsin Liu
Publikováno v:
Developmental Cell. 16:280-291
SummaryNk-2 proteins are essential developmental regulators from flies to humans. In Drosophila, the family member tinman is the major regulator of cell fate within the dorsal mesoderm, including heart, visceral, and dorsal somatic muscle. To deciphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda8813795eb0a9faf217f26d00a4f60
https://doi.org/10.1016/j.devcel.2009.01.006
https://doi.org/10.1016/j.devcel.2009.01.006
Autor:
Janus S. Jakobsen, Francesco Limone, Bruno Di Stefano, Bo T. Porse, Mirko Francesconi, Matthias Mann, Samuel Collombet, Denis Thieffry, Carolina Segura-Morales, Michael Wierer, Jose Luis Sardina, Thomas Graf, Ralph Stadhouders, Andreas Lackner
Publikováno v:
Nature Cell Biology
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) is typically inefficient and has been explained by elite-cell and stochastic models. We recently reported that B cells exposed to a pulse of C/EBPα (Bα' cells) behave as elite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74228d37b09930b239241fd3cac2b7fd
https://pubmed.ncbi.nlm.nih.gov/26974661
https://pubmed.ncbi.nlm.nih.gov/26974661
Autor:
Anne-Katrine Frank, Johannes Waage, Frederik Otzen Bagger, Bo T. Porse, Mikkel Bruhn Schuster, Kristoffer Vitting-Seerup, Marie Sigurd Hasemann, Janus S. Jakobsen
Publikováno v:
BMC Genomics
Jakobsen, J S, Bagger, F O, Hasemann, M S, Schuster, M B, Frank, A-K, Waage, J, Vitting-Seerup, K & Porse, B T 2015, ' Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq ', BMC Genomics, vol. 16, pp. 46 . https://doi.org/10.1186/s12864-014-1195-4
Jakobsen, J S, Bagger, F O, Hasemann, M S, Schuster, M B, Frank, A-K, Waage, J, Vitting-Seerup, K & Porse, B T 2015, ' Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq ', BMC Genomics, vol. 16, pp. 46 . https://doi.org/10.1186/s12864-014-1195-4
Background Chromatin-Immunoprecipitation coupled with deep sequencing (ChIP-seq) is used to map transcription factor occupancy and generate epigenetic profiles genome-wide. The requirement of nano-scale ChIP DNA for generation of sequencing libraries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c3546f36b3819d90291ab03116b70c
https://doi.org/10.1186/s12864-014-1195-4
https://doi.org/10.1186/s12864-014-1195-4