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of 53
pro vyhledávání: '"Janupally Renuka"'
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Manoj Chandran, Janupally Renuka, Jonnalagadda Padma Sridevi, Ganesh S Pedgaonkar, Vanaparthi Asmitha, Perumal Yogeeswari, Dharmarajan Sriram
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel thera
Externí odkaz:
https://doaj.org/article/75ea5bd0e2334e23a8d2f38b31482be6
Autor:
Jeankumar, Variam Ullas, Reshma, Rudraraju Srilakshmi, Vats, Rahul, Janupally, Renuka, Saxena, Shalini, Yogeeswari, Perumal, Sriram, Dharmarajan
Publikováno v:
In European Journal of Medicinal Chemistry 21 October 2016 122:216-231
Autor:
Sridevi, Jonnalagadda Padma, Suryadevara, Priyanka, Janupally, Renuka, Sridhar, Jogula, Soni, Vijay, Anantaraju, Hasitha Shilpa, Yogeeswari, Perumal, Sriram, Dharmarajan
Publikováno v:
In European Journal of Pharmaceutical Sciences 25 May 2015 72:81-92
Autor:
Jeankumar, Variam Ullas, Kotagiri, Sonali, Janupally, Renuka, Suryadevara, Priyanka, Sridevi, Jonnalagadda Padma, Medishetti, Raghavender, Kulkarni, Pushkar, Yogeeswari, Perumal, Sriram, Dharmarajan
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 February 2015 23(3):588-601
Autor:
Janupally, Renuka, Jeankumar, Variam Ullas, Bobesh, Karyakulam Andrews, Soni, Vijay, Devi, Parthiban Brindha, Pulla, Venkat Koushik, Suryadevara, Priyanka, Chennubhotla, Keerthana Sharma, Kulkarni, Pushkar, Yogeeswari, Perumal, Sriram, Dharmarajan
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 November 2014 22(21):5970-5987
Autor:
Pushkar Kulkarni, Rudraraju Reshma Srilakshmi, Karyakulam Andrews Bobesh, Dharmarajan Sriram, Janupally Renuka, Swapna Yellanki, Perumal Yogeeswari
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:42-52
Recently numerous non-fluoroquinolone-based bacterial type II topoisomerase inhibitors from both the GyrA and GyrB classes have been reported as antibacterial agents. Inhibitors of the GyrA class include aminopiperidine-based novel bacterial type II
Autor:
Janupally, Renuka1, Medepi, Bhramam1, Brindha Devi, Parthiban1, Suryadevara, Priyanka1, Jeankumar, Variam Ullas1, Kulkarni, Pushkar2,3, Yogeeswari, Perumal1, Sriram, Dharmarajan1
Publikováno v:
Chemical Biology & Drug Design. Oct2015, Vol. 86 Issue 4, p918-925. 8p.
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Autor:
Ganesh S. Pedgaonkar, Perumal Yogeeswari, Dharmarajan Sriram, Janupally Renuka, Vanaparthi Asmitha, Jonnalagadda Padma Sridevi, Manoj Chandran
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 2, Pp 104-115 (2015)
Background and objectives Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therap
Autor:
Dharmarajan Sriram, Shailendra K. Saxena, Janupally Renuka, Jonnalagadda Padma Sridevi, Brahmam Medapi, Perumal Yogeeswari, Raghavender Medishetti, Pushkar Kulkarni
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2062-2078
Antibiotics with good therapeutic value and novel mechanism of action are becoming increasingly important in today's battle against bacterial resistance. One of the popular targets being DNA gyrase, is currently becoming well-established and clinical
Autor:
Jonnalagadda Padma Sridevi, Morla Shravan, Dharmarajan Sriram, Variam Ullas Jeankumar, Janupally Renuka, Kummetha Indrasena Reddy, Kondra Sudhakar Babu, Konduri Srihari, Perumal Yogeeswari
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4924-4934
DNA gyrase of Mycobacterium tuberculosis (MTB) is a type II topoisomerase and is a well-established and validated target for the development of novel therapeutics. By adapting the medium throughput screening approach, we present the discovery and opt