Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Januka S Athukoralage"'
Autor:
Januka S Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M Gloster, Malcolm F White
Publikováno v:
eLife, Vol 9 (2020)
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid o
Externí odkaz:
https://doaj.org/article/0d1373e96dfd4832a55e12e447f7ab9a
Autor:
Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M Czekster, Malcolm F White
Publikováno v:
eLife, Vol 9 (2020)
Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to
Externí odkaz:
https://doaj.org/article/afca9bf979b645389754febb33d49a97
Publikováno v:
eLife, Vol 7 (2018)
The CRISPR system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III systems adopt an activated state that licenses DNA interference and synth
Externí odkaz:
https://doaj.org/article/34cba8ca92234df990721dabcd09cf9f
Autor:
Erin Huiting, Xueli Cao, Jie Ren, Januka S. Athukoralage, Zhaorong Luo, Sukrit Silas, Na An, Héloïse Carion, Yu Zhou, James S. Fraser, Yue Feng, Joseph Bondy-Denomy
Publikováno v:
Cell. 186:864-876.e21
Publikováno v:
RNA
In prokaryotes, CRISPR-Cas immune systems recognize and cleave foreign nucleic acids to defend against mobile genetic elements (MGEs). Type III CRISPR-Cas complexes also synthesize cyclic oligoadenylate (cOA) second messengers, which activate CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff25abc9f239a819e377f864c1fef62e
https://europepmc.org/articles/PMC8284326/
https://europepmc.org/articles/PMC8284326/
Publikováno v:
Nucleic Acids Research
Royal Society Challenge Grant [REF: CH160014 to M.F.W.]; Biotechnology and Biological Sciences Research Council [REF: BB/S000313/1 to M.F.W.]. Funding for open access charge: Institutional Block Grant. The CRISPR system provides adaptive immunity aga
Publikováno v:
Nucleic Acids Research
Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) second messengers in response to viral infection of bacteria and archaea, potentiating an immune response by binding and activating ancillary effector nucleases such as Csx1. As these eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7053a64e80e4908bd076262ac4f5de32
https://hdl.handle.net/10023/19884
https://hdl.handle.net/10023/19884
Autor:
Sabine Grüschow, Malcolm F. White, Tracey M. Gloster, Januka S Athukoralage, Shirley Graham, Stuart McQuarrie
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff85a643332ecc71b1531901ed733df1
https://doi.org/10.1101/2020.04.28.066118
https://doi.org/10.1101/2020.04.28.066118
Autor:
Clarissa M. Czekster, Shirley Graham, Malcolm F. White, Januka S Athukoralage, Sabine Grüschow, Christophe Rouillon
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
This work was supported by a grant from the Biotechnology and Biological Sciences Research Council (Grant REF BB/S000313/1 to MFW) and the Wellcome Trust (Grant 210486/Z/18/Z to CMC). Cyclic nucleotide second messengers are increasingly implicated in