Výsledky vyhledávání - "Jantine A C Broek"

Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum

Autor: Paula Suárez-Pinilla, Jordan M. Ramsey, Bonnie Auyeug, Volker Arolt, Jantine A. C. Broek, Tillmann Ruland, Marina Rubey, Olya Mikova, Javier Vázquez-Bourgon, Sergi Papiol, Frieder Haenisch, Sabine Bahn, Emiliano Gonzalez-Vioque, Santiago G. Lago, Geertje F. van Rees, Nikolett Kabacs, Jakub Tomasik, Benedicto Crespo-Facorro, Simon Baron-Cohen

Publikováno v: Brain, Behavior, and Immunity. Volume 91, January 2021, Pages 673-682
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
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Recent evidence suggests that comorbidities between neuropsychiatric conditions and metabolic syndrome may precede and even exacerbate long-term side-effects of psychiatric medication, such as a higher risk of type 2 diabetes and cardiovascular disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cddc4ec7faa057300191c4758617894
https://doi.org/10.1016/j.bbi.2020.07.043

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Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks

Autor: Jordan M. Ramsey, Frieder Haenisch, Olya Mikova, Bonnie Auyeug, Jantine A. C. Broek, Tillmann Ruland, Simon Baron-Cohen, Jakub Tomasik, Nikolett Kabacs, Jason D. Cooper, Paula Suárez-Pinilla, Volker Arolt, Geertje F. van Rees, Santiago G. Lago, Benedicto Crespo-Facorro, Sabine Bahn

Publikováno v: Lago, S G, Tomasik, J, van Rees, G F, Ramsey, J M, Haenisch, F, Cooper, J D, Broek, J A, Suarez-Pinilla, P, Ruland, T, Auyeung, B, Mikova, O, Kabacs, N, Arolt, V, Baron-Cohen, S, Crespo-Facorro, B & Bahn, S 2018, ' Exploring the neuropsychiatric spectrum using high-content functional analysis of single-cell signaling networks ', Molecular Psychiatry, pp. 1-18 . https://doi.org/10.1038/s41380-018-0123-4

Neuropsychiatric disorders overlap in symptoms and share genetic risk factors, challenging their current classification into distinct diagnostic categories. Novel cross-disorder approaches are needed to improve our understanding of the heterogeneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff30939d496f4cd0b4b3a51cfd107b9
https://www.repository.cam.ac.uk/handle/1810/292585

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ANERGY TO SYNERGY-THE ENERGY FUELING THE RXCOVEA FRAMEWORK

Autor: Evelyne Bischof, Jantine A C Broek, Hillary W. Gao, Ashley J. Duits, Lex van der Ploeg, Bud Mishra, Larry Rudolph, Tamar Schlick, RxCOVEA Framework, Charles R. Cantor, Naomi I Maria, Alfredo Ferro, Stella Luna de Maria, Zilong Li, Kimberly I. Mishra

Publikováno v: Int J Multiscale Comput Eng

We write to introduce our novel group formed to confront some of the issues raised by the COVID-19 pandemic. Information about the group, which we named "cure COVid for Ever and for All" (RxCOVEA), its dynamic membership (changing regularly), and som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f6eff883d7eb520507d5198e344abb
https://pubmed.ncbi.nlm.nih.gov/32831809

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Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

Autor: Sabine Bahn, Joseph A. Gogos, Karine Fénelon, James M. O'Donnell, Heather McKellar, Jantine A. C. Broek, Ziyi Sun, Lan Xiao, Gregg W. Crabtree, Bin Xu, Mirna Kvajo

Using a genetic mouse model that faithfully recapitulates aDISC1genetic alteration strongly associated with schizophrenia and other psychiatric disorders, we examined the impact of this mutation within the prefrontal cortex. Although cortical layerin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd096548a02787c71396a09fb29eb4f2
https://europepmc.org/articles/PMC5391686/

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Synaptic vesicle dynamic changes in a model of fragile X

Autor: Jantine A. C. Broek, Sabine Bahn, Elize D. Haasdijk, Rob Willemsen, Heleen M van 't Spijker, Sureyya Ozcan, Zhanmin Lin, Adriaan B. Houtsmuller, H. Martijn de Gruiter, David Cox, Gert van Cappellen, Chris I. De Zeeuw

Publikováno v: Molecular Autism, 7. BioMed Central Ltd.
Molecular Autism
Molecular Autism, 7. BioMed Central

Background Fragile X syndrome (FXS) is a single-gene disorder that is the most common heritable cause of intellectual disability and the most frequent monogenic cause of autism spectrum disorders (ASD). FXS is caused by an expansion of trinucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008fcd2235abf94ccafe9437488e661d
https://doi.org/10.1186/s13229-016-0080-1

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Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study

Autor: Jeannine Schoenfelder, Meng Xia, Sabine Bahn, Akira Sawa, Sofya Abazyan, Hanna Jaaro-Peled, Yan Jouroukhin, Mikhail V. Pletnikov, Jantine A. C. Broek

Publikováno v: Molecular neuropsychiatry. 2(1)

Despite the recent progress in psychiatric genetics, very few studies have focused on genetic risk factors in glial cells that, compared to neurons, can manifest different molecular pathologies underlying psychiatric disorders. In order to address th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44574f91617130cfeec9d9101a50548
https://pubmed.ncbi.nlm.nih.gov/27606318

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Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

Autor: Paul C. Guest, Jantine A. C. Broek, Hassan Rahmoune, Sabine Bahn

Publikováno v: Molecular Autism, 5. BioMed Central Ltd.
Molecular Autism

Background: Autism is a neurodevelopmental disorder characterized by impaired language, communication and social skills. Although genetic studies have been carried out in this field, none of the genes identified have led to an explanation of the unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5983c37c843676dca7cb56e20a9f77
https://pure.eur.nl/en/publications/50a3116b-4961-47aa-9f98-e90f2ba8741f

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Proteomics investigation identifies prominent changes in synapse-related proteins in a fragile X mouse model

Autor: Rob Willemsen, Zhanmin Lin, C. I. De Zeeuw, Sureyya Ozcan, Sabine Bahn, Jantine A. C. Broek, HM De Gruiter, Elize D. Haasdijk, H Van't Spijker

Publikováno v: BMC Neuroscience

Fragile X syndrome (FXS) is a single gene disorder that is the most common heritable cause of intellectual disability and the most frequent monogenic cause of autism spectrum disorders (ASD). FXS is caused by trinucleotide repeats in the promoter reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317eb9fecfcadff8f1f51f3ee79bab50
http://europepmc.org/articles/PMC4697481

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Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

Autor: Sabine Bahn, Paul C. Guest, Barbara Franke, Jordan M. Ramsey, Jeffrey C. Glennon, Jantine A. C. Broek, Jan K. Buitelaar, Hassan Rahmoune, Nanda Rommelse

Publikováno v: Molecular Autism; Vol 4
Molecular Autism, 4. BioMed Central Ltd.
Molecular Autism, 4, 1, pp. 27
Molecular Autism, 4, 27
Molecular Autism

Background Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes i

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