Výsledky vyhledávání - "Jantien J. Kettenes-van den Bosch"

Poly(N-isopropylacrylamide) with hydrolyzable lactic acid ester side groups: a new type of thermosensitive polymer

Autor: Wim E. Hennink, D. Neradovic, Wouter L. J. Hinrichs, Jantien J. Kettenes-van den Bosch

Publikováno v: Macromolecular Rapid Communications. 20:577-581

N-isopropylacrylamide (NIPAAm) was copolymerized with 2-hydroxyethyl methacrylate-monolactate (HEMA-monolactate). With increasing HEMA-monolactate content in the copolymer, the lower critical solution temperature (LCST) decreases. During incubation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab8d8176bb18094a9c27e21faecea478
https://doi.org/10.1002/(sici)1521-3927(19991101)20:11<577::aid-marc577>3.0.co

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Synthesis and electrospray mass spectrometric studies on a chiral, non-racemic, phosphoramide receptor molecule

Autor: Albert J. R. Heck, Jennifer A. Kenny, Athene R.C. Smith, Martin Wills, Jantien J. Kettenes-van den Bosch

Publikováno v: Tetrahedron: Asymmetry. 10:3267-3271

The synthesis of a class of macrocyclic receptors containing a phosphoramide is described. The preliminary evaluation of this new receptor for interactions with several homochiral amines using electrospray ionisation mass spectrometry is also describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4c730567c768a4018d80486822662c3
https://doi.org/10.1016/s0957-4166(99)00369-9

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Bioanalysis of aplidine, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography after derivatization with trans-4′-hydrazino-2-stilbazole

Autor: Jantien J. Kettenes-van den Bosch, Roland E. C. Henrar, Olaf van Tellingen, Pablo Floriano, Jos H. Beijnen, Glynn Faircloth, Kenneth L. Rinehart, Bastiaan Nuyen, Jose Jimeno, Rolf W. Sparidans

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 729:43-53

A sensitive bio-analytical assay in plasma of the depsipeptide aplidine is reported, based on reversed-phase liquid chromatography and fluorescence detection of the trans-4'-hydrazino-2-stilbazole (4'H2S) derivative of the analyte. At ambient tempera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d916efec5a3d2c99adb49e1b3f3119b8
https://doi.org/10.1016/s0378-4347(99)00118-8

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Synthesis and characterization of poly-L-lysine with controlled low molecular weight

Autor: Wijnand J. W. Schuyl, Petra van de Wetering, Jantien J. Kettenes-van den Bosch, Wim E. Hennink, Leon G. A. van de Water, Wendelmoed N. E. Van Dijk-Wolthuis, Mies J. van Steenbergen

Publikováno v: Macromolecular Chemistry and Physics. 198:3893-3906

N-Carboxy-(N e -benzyloxycarbonyl)-L-lysine anhydride (Z-L-lysine NCA) was polymerized in dimethylformamide with triethylamine, diethylamine or hexylamine as initiator, at varying molar ratios of NCA to initiator (M/I ratio). After removal of the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36c304ec76b84f67c0a1e821b8a7719c
https://doi.org/10.1002/macp.1997.021981211

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Capillary zone electrophoresis–mass spectrometry as a tool in the stability research of the luteinising hormone-releasing hormone analogue goserelin

Autor: Jantien J. Kettenes-van den Bosch, Marnix A. Hoitink, Willy J. M. Underberg, Ed Hop, Auke Bult, Jos H. Beijnen

Publikováno v: Journal of Chromatography A. 776:319-327

A capillary zone electrophoresis (CZE)–MS system for peptide analysis was developed, characterised and applied in the stability research of goserelin, a luteinising hormone-releasing hormone analogue. 10% acetic acid was used as running solution. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36cee2a985aef8069554cea1cef0c3b3
https://doi.org/10.1016/s0021-9673(97)00349-x

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Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography

Autor: Matthijs M. Tibben, Thomas Kerbusch, Jantien J. Kettenes-van den Bosch, Alwin D. R. Huitema, Sjoerd Rodenhuis, Jos H. Beijnen

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 745(2)

A simple and selective assay for the determination of the alkylating cyclophosphamide metabolite phosphoramide mustard (PM) in plasma was developed and validated. PM was determined after derivatisation by high-performance liquid chromatography (HPLC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545e7c58c1f566bc3bb1ab5e2aeb6579
https://pubmed.ncbi.nlm.nih.gov/11043753

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Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography

Autor: Jantien J. Kettenes-van den Bosch, Cornelis Versluis, Jos H. Beijnen, Auke Bult, Olaf van Tellingen, Anneloes L. C. Sonneveldt, W. J. Nooijen

Publikováno v: Cancer chemotherapy and pharmacology. 33(5)

We investigated the pharmacokinetics of the experimental semisynthetic vinca alkaloid vinleucinol (VileE; O4-deacetyl-3-de(methoxycarbonyl)-3-[[[1-ethoxycarbonyl-2- methylbutyl]amino]carbonyl]-vincaleukoblastine). The study was performed in male FVB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c82d6f74963e2b2e3413378641a2d4
https://pubmed.ncbi.nlm.nih.gov/8306418

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Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244)

Autor: Roland E. C. Henrar, Jantine D. Jonkman-de Vries, Marga J. A. de Graaff-Teulen, Auke Bult, Jantien J. Kettenes-van den Bosch, Jos H. Beijnen

Publikováno v: Investigational new drugs. 12(4)

The aim of this study was to design a parenteral dosage form for the investigational cytotoxic drug carzelesin. A stable formulation in PET (Polyethylene glycol 400/absolute ethanol/Tween 80, 6:3:1, v/v/v) was developed. The prototype, containing 0.5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80bd66316d1ad9e401323793e8ee43f
https://pubmed.ncbi.nlm.nih.gov/7775131

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Pharmaceutical development of a parenteral lyophilized formulation of the novel indoloquinone antitumor agent EO9

Autor: Auke Bult, Jantien J. Kettenes-van den Bosch, Herre Talsma, Jantine D. Jonkman-de Vries, Roland E. C. Henrar, Jos H. Beijnen

Publikováno v: Cancer chemotherapy and pharmacology. 34(5)

The aim of this study was to design a stable parenteral dosing form of the investigational cytotoxic drug, encoded EO9. EO9 exhibits poor aqueous solubility and stability characteristics. Freeze-drying was selected as the manufacturing process. Diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3321a6e6411509f161c6d086f046535
https://pubmed.ncbi.nlm.nih.gov/8070009

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