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Ankles back in randomized controlled trial (ABrCt): braces versus neuromuscular exercises for the secondary prevention of ankle sprains. Design of a randomised controlled trial

Autor: Verhagen Evert ALM, van Mechelen Willem, Janssen Kasper W

Publikováno v: BMC Musculoskeletal Disorders, Vol 12, Iss 1, p 210 (2011)

Abstract Background Ankle sprains are the most common sports and physical activity related injury. There is extensive evidence that there is a twofold increased risk for injury recurrence for at least one year post injury. In up to 50% of all cases r

Externí odkaz: https://doaj.org/article/c389268a152e4aaca1765bccf25b9099

Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Autor: Topper MJ; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Guarnieri JW; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Haltom JA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Chadburn A; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065., Cope H; School of Medicine, University of Nottingham, Derby DE22 3DT, United Kingdom., Frere J; Icahn School of Medicine, Mount Sinai, New York, NY 10023., An J; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Borczuk A; Weill Cornell Medicine, New York, NY 10065., Sinha S; Weill Cornell Medicine, New York, NY 10065., Kim J; Weill Cornell Medicine, New York, NY 10065., Park J; Weill Cornell Medicine, New York, NY 10065., Butler D; Weill Cornell Medicine, New York, NY 10065., Meydan C; Weill Cornell Medicine, New York, NY 10065., Foox J; Weill Cornell Medicine, New York, NY 10065., Bram Y; Weill Cornell Medicine, New York, NY 10065., Richard SA; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Epsi NJ; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Agan B; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Chenoweth JG; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Simons MP; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Tribble D; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Burgess T; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814., Dalgard C; Department of Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD 20814., Heise MT; University of North Carolina, Chapel Hill, NC 27599., Moorman NJ; University of North Carolina, Chapel Hill, NC 27599., Baxter VK; University of North Carolina, Chapel Hill, NC 27599., Madden EA; University of North Carolina, Chapel Hill, NC 27599., Taft-Benz SA; University of North Carolina, Chapel Hill, NC 27599., Anderson EJ; University of North Carolina, Chapel Hill, NC 27599., Sanders WA; University of North Carolina, Chapel Hill, NC 27599., Dickmander RJ; University of North Carolina, Chapel Hill, NC 27599., Beigel K; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Biomedical and Health, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Widjaja GA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Janssen KA; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Lie T; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Murdock DG; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Angelin A; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Soto Albrecht YE; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; The University of Pennsylvania, Philadelphia, PA 19104., Olali AZ; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Cen Z; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Dybas J; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Priebe W; COVID-19 International Research Team, Medford, MA 02155.; University of Texas Monroe Dunaway Anderson Cancer Center, Houston, TX 77030., Emmett MR; COVID-19 International Research Team, Medford, MA 02155.; University of Texas Medical Branch, Galveston, TX 77555., Best SM; COVID-19 International Research Team, Medford, MA 02155.; Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840., Kelsey Johnson M; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287., Trovao NS; COVID-19 International Research Team, Medford, MA 02155.; Fogarty International Center, NIH, Bethesda, MD 20892., Clark KB; COVID-19 International Research Team, Medford, MA 02155.; Cures Within Reach, Chicago, IL 60602.; Champions Service, Computational Sciences Support Network, Multi-Tier Assistance, Training, and Computational Help Track, NSF's Advanced Cyberinfrastructure Coordination Ecosystem: Services and Support, Carnegie-Mellon University, Pittsburgh, PA 15213., Zaksas V; COVID-19 International Research Team, Medford, MA 02155.; Center for Translational Data Science, University of Chicago, Chicago, IL 60615.; Clever Research Lab, Springfield, IL 62704., Meller R; COVID-19 International Research Team, Medford, MA 02155.; Morehouse School of Medicine, Atlanta, GA 30310., Grabham P; COVID-19 International Research Team, Medford, MA 02155.; Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 19103., Schisler JC; COVID-19 International Research Team, Medford, MA 02155.; University of North Carolina, Chapel Hill, NC 27599., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA 02155.; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil 13083-862., Pollett S; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda, MD 20814.; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817., Mason CE; COVID-19 International Research Team, Medford, MA 02155.; Weill Cornell Medicine, New York, NY 10065.; New York Genome Center, New York, NY 10013., Syrkin Wurtele E; COVID-19 International Research Team, Medford, MA 02155.; Center for Metabolic Biology, Bioinformatics and Computational Biology, and Genetics Development, and Cell Biology, Iowa State University, Ames, IA 50011.; Center for Bioinformatics and Computational Biology Iowa State University, Ames, IA 50011.; Center for Genetics Development, and Cell Biology Iowa State University, Ames, IA 50011., Taylor D; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Biomedical and Health, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104., Schwartz RE; COVID-19 International Research Team, Medford, MA 02155.; Weill Cornell Medicine, New York, NY 10065., Beheshti A; COVID-19 International Research Team, Medford, MA 02155.; Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Blue Marble Space Institute of Science, Seattle, WA 98104.; McGowan Institute for Regenerative Medicine and Center for Space Biomedicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219., Wallace DC; COVID-19 International Research Team, Medford, MA 02155.; The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104., Baylin SB; COVID-19 International Research Team, Medford, MA 02155.; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.; Van Andel Institute, Grand Rapids, MI 49503.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 03; Vol. 121 (49), pp. e2401968121. Date of Electronic Publication: 2024 Nov 27.

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.

Autor: Liu X; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Devadiga SA; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Stanley RF; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Morrow RM; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Janssen KA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Quesnel-Vallières M; Department of Biochemistry and Biophysics and., Pomp O; Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Moverley AA; Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Li C; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Skuli N; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Carroll M; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Huang J; Coriell Institute for Medical Research, Camden, New Jersey, USA., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lynch KW; Department of Biochemistry and Biophysics and., Abdel-Wahab O; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Klein PS; Department of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 07; Vol. 134 (12). Date of Electronic Publication: 2024 May 07.