Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Janset Onyuru"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 481-497 (2024)
Background & Aims: Breast regression protein 39 (BRP39) (Chi3L1) and its human homolog YKL-40, is an established biomarker of liver fibrosis in nonalcoholic steatohepatitis (NASH) patients, but its role in NASH pathogenesis remains unclear. We recent
Externí odkaz:
https://doaj.org/article/0912e3a866a448f6a829e475f32d388a
Autor:
Christian Stoess, Yeon-Kyung Choi, Janset Onyuru, Helmut Friess, Hal M. Hoffman, Daniel Hartmann, Ariel E. Feldstein
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 559 (2024)
Cell death is crucial for maintaining tissue balance and responding to diseases. However, under pathological conditions, the surge in dying cells results in an overwhelming presence of cell debris and the release of danger signals. In the liver, this
Externí odkaz:
https://doaj.org/article/9a038d8743d54482831945e945d0ad48
Autor:
Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman
Publikováno v:
The Journal of Immunology.
Antisense oligonucleotides (ASOs) are a novel therapeutic strategy that targets a specific gene and suppresses its expression. The cryopyrin-associated periodic syndromes (CAPS) are a spectrum of autoinflammatory diseases characterized by systemic an
Autor:
Benedikt Kaufmann, Aleksandra Leszczynska, Agustina Reca, Laela M Booshehri, Janset Onyuru, ZheHao Tan, Alexander Wree, Helmut Friess, Daniel Hartmann, Bettina Papouchado, Lori Broderick, Hal M Hoffman, Ben A Croker, Yanfang Peipei Zhu, Ariel E Feldstein
Publikováno v:
EMBO reports. 23
Sterile inflammation is a central element in liver diseases. The immune response following injurious stimuli involves hepatic infiltration of neutrophils and monocytes. Neutrophils are major effectors of liver inflammation, rapidly recruited to sites
Autor:
Hongxu Xian, Kosuke Watari, Elsa Sanchez-Lopez, Joseph Offenberger, Janset Onyuru, Harini Sampath, Wei Ying, Hal M. Hoffman, Gerald S. Shadel, Michael Karin
Publikováno v:
Immunity. 55:1370-1385.e8
Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3, thereby triggering inflammasome activation. However, it is unknown how and in wh