Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

Autor: Zaal, Esther A, de Grooth, Harm-Jan, Oudaert, Inge, Langerhorst, Pieter, Levantovsky, Sophie, van Slobbe, Gijs J J, Jansen, Jeroen W A, Menu, Eline, Wu, Wei, Berkers, Celia R, Veterinaire biochemie, IOV MS, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., dB&C FR-RMSC RMSC, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Zaal, E A, de Grooth, H-J, Oudaert, I, Langerhorst, P, Levantovsky, S, van Slobbe, G J J, Jansen, J W A, Menu, E, Wu, W & Berkers, C R 2022, ' Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma ', Molecular omics, vol. 18, no. 1, pp. 19-30 . https://doi.org/10.1039/d1mo00106j
Molecular omics, 18(1), 19-30. Royal Society of Chemistry
Molecular Omics, 18(1), 19. Royal Society of Chemistry

During the development of drug resistance, multiple myeloma (MM) cells undergo changes to their metabolism. However, how these metabolic changes can be exploited to improve treatment efficacy is not known. Here we demonstrate that targeting coenzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96a6c4c090a7de18e407392706b19c3
https://research.vumc.nl/en/publications/a38a3d38-598d-4978-93f8-bfb59091b273

Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides

Autor: Balhuizen, Melanie D, van Dijk, Albert, Jansen, Jeroen W A, van de Lest, Chris H A, Veldhuizen, Edwin J A, Haagsman, Henk P, Moleculaire afweer, dI&I I&I-3, IOV MS, Equine Musculoskeletal Biology, Veterinaire biochemie, dB&C FR-RMSC RMSC, dES RMSC, Immunologie

Publikováno v: mSphere
mSphere, 6(4), 1. American Society for Microbiology
mSphere, Vol 6, Iss 4 (2021)

Host defense peptides (HDPs) are part of the innate immune system and constitute a first line of defense against invading pathogens. They possess antimicrobial activity against a broad spectrum of pathogens. However, pathogens have been known to adap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72764a1e7943e5a7179231e5f367102a
https://dspace.library.uu.nl/handle/1874/412597

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Stable Isotope Tracing Experiments Using LC-MS.

Autor: Zaal EA; Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. e.a.zaal@uu.nl.; Metabolism Expertise Centre, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. e.a.zaal@uu.nl., Jansen JWA; Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.; Metabolism Expertise Centre, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Berkers CR; Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.; Metabolism Expertise Centre, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2855, pp. 103-116.