Cyclic nitrone free radical traps: isolation, identification, and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects

Autor: Jones Bk, Thomas Ce, Leo A. Paquette, Keeley Fj, Dirk Friedrich, Fevig Tl, Patrick Bernardelli, Janowick Da, Chaney Sf, Kehne Jh, Bowen Sm, Ohlweiler Df, Robke Dj, Ketteler B

Publikováno v: Journal of medicinal chemistry. 39(25)

A C-4 hydroxylated metabolite (2, 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide) of the previously described cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4-dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00347ea7f06020bbd19d9047722fc380
https://pubmed.ncbi.nlm.nih.gov/8960560

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.

Autor: Sells TB; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Chau R; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Ecsedy JA; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Gershman RE; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Hoar K; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Huck J; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Janowick DA; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Kadambi VJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., LeRoy PJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Stirling M; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Stroud SG; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Vos TJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Weatherhead GS; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Wysong DR; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Zhang M; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Balani SK; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Bolen JB; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Manfredi MG; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Claiborne CF; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 22; Vol. 6 (6), pp. 630-4. Date of Electronic Publication: 2015 Apr 22 (Print Publication: 2015).

Design, synthesis, and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke.

Autor: Fevig TL; Hoechst Marion Roussel, Inc., Cincinnati, Ohio 45215, USA., Bowen SM, Janowick DA, Jones BK, Munson HR, Ohlweiler DF, Thomas CE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1996 Dec 06; Vol. 39 (25), pp. 4988-96.