Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Janosch, Hennig"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1100-1114 (2024)
RNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range from transcription regulation up to maintaining genomic stability and viral defence. As dysre
Externí odkaz:
https://doaj.org/article/20f4c881f36a48be8f174c8d6de45e96
Autor:
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut
Externí odkaz:
https://doaj.org/article/d8245675d28e4b2bbc482fdb79f08563
Autor:
Valentin Bohl, Nele Merret Hollmann, Tobias Melzer, Panagiotis Katikaridis, Lena Meins, Bernd Simon, Dirk Flemming, Irmgard Sinning, Janosch Hennig, Axel Mogk
Publikováno v:
eLife, Vol 12 (2024)
Heat stress can cause cell death by triggering the aggregation of essential proteins. In bacteria, aggregated proteins are rescued by the canonical Hsp70/AAA+ (ClpB) bi-chaperone disaggregase. Man-made, severe stress conditions applied during, e.g.,
Externí odkaz:
https://doaj.org/article/f1f84471eab94033a5c0219bacf5ae11
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 644-655 (2020)
Protein–protein and protein–ligand interactions often involve conformational changes or structural rearrangements that can be quantified by solution small-angle X-ray scattering (SAXS). These scattering intensity measurements reveal structural de
Externí odkaz:
https://doaj.org/article/db5f8e2ca0f24f28890b8e6ccdf69f5d
Autor:
Jie Yang, Vladimir O. Talibov, Stefan Peintner, Claire Rhee, Vasanthanathan Poongavanam, Matthis Geitmann, Matteo Rossi Sebastiano, Bernd Simon, Janosch Hennig, Doreen Dobritzsch, U. Helena Danielson, Jan Kihlberg
Publikováno v:
ACS Omega, Vol 5, Iss 8, Pp 3979-3995 (2020)
Externí odkaz:
https://doaj.org/article/49645015752a4b7e83c6cc6080b839b7
Autor:
Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF
Externí odkaz:
https://doaj.org/article/72d38bbd5c5341449dcf400e10a51167
Autor:
Marios G. Koliopoulos, Mathilde Lethier, Annemarthe G. van der Veen, Kevin Haubrich, Janosch Hennig, Eva Kowalinski, Rebecca V. Stevens, Stephen R. Martin, Caetano Reis e Sousa, Stephen Cusack, Katrin Rittinger
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition
Externí odkaz:
https://doaj.org/article/37466ebb4272497c9f39f54fcc779957
Autor:
Wolfram Volkwein, Ralph Krafczyk, Pravin Kumar Ankush Jagtap, Marina Parr, Elena Mankina, Jakub Macošek, Zhenghuan Guo, Maximilian Josef Ludwig Johannes Fürst, Miriam Pfab, Dmitrij Frishman, Janosch Hennig, Kirsten Jung, Jürgen Lassak
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Tripeptides with two consecutive prolines are the shortest and most frequent sequences causing ribosome stalling. The bacterial translation elongation factor P (EF-P) relieves this arrest, allowing protein biosynthesis to continue. A seven amino acid
Externí odkaz:
https://doaj.org/article/fe7ad7c7b8a647ccb645ebe6c6169dd8
Autor:
Andreas Baumann, Daniel Isak, Jasmin Lohbeck, Pravin Kumar Ankush Jagtap, Janosch Hennig, Aubry K. Miller
Publikováno v:
RSC Advances. 12:26989-26993
We report scalable syntheses of two potent and selective kallikrein related peptidase 6 (KLK6) inhibitors, as well as X-ray crystal structures of both inhibitors as protein-ligand complexes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5ee85c8c39399412f0718a3858059e
https://doi.org/10.1039/d2ra04670a
https://doi.org/10.1039/d2ra04670a
Autor:
Nele Merret Hollmann, Pravin Kumar Ankush Jagtap, Johanna-Barbara Linse, Philip Ullmann, Marco Payr, Brice Murciano, Bernd Simon, Jochen S Hub, Janosch Hennig
Publikováno v:
Nucleic acids research 51(4), 1895-1913 (2023). doi:10.1093/nar/gkac1277
Nucleic acids research 51(4), 1895 - 1913 (2023). doi:10.1093/nar/gkac1277
RNA binding proteins (RBPs) often engage multiple RNA binding domains (RBDs) to increase target specificity and affinity. However, the complexity of target recognition of
RNA binding proteins (RBPs) often engage multiple RNA binding domains (RBDs) to increase target specificity and affinity. However, the complexity of target recognition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2b55528f40af1d8ba315d8098134c4
https://bib-pubdb1.desy.de/record/580708
https://bib-pubdb1.desy.de/record/580708
