Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Janosch, Ehrenmann"'
Autor:
Yann Waltenspühl, Janosch Ehrenmann, Santiago Vacca, Cristian Thom, Ohad Medalia, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here, Waltenspühl et al. report the cryo-EM structure of active human oxytocin receptor in complex with oxytocin and with a heterotrimeric G protein, providing insights into this hormone system critically involved in the regulation of social behavio
Externí odkaz:
https://doaj.org/article/5e8642019ba84ce2809030eeaafcf0db
Autor:
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinical
Externí odkaz:
https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
Publikováno v:
Molecules, Vol 26, Iss 5, p 1465 (2021)
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have b
Externí odkaz:
https://doaj.org/article/32bcdb1efb6c4f54a379fb8c496ae1a0
Autor:
Cristian, Thom, Janosch, Ehrenmann, Santiago, Vacca, Yann, Waltenspühl, Jendrik, Schöppe, Ohad, Medalia, Andreas, Plückthun
Publikováno v:
Science Advances
Description
Neuropeptide-bound NK1R:G protein complex structures explain mechanisms ranging from insurmountable antagonism to activation.
The neurokinin 1 receptor (NK1R) is involved in inflammation and pain transmission. This pathophysiolo
Neuropeptide-bound NK1R:G protein complex structures explain mechanisms ranging from insurmountable antagonism to activation.
The neurokinin 1 receptor (NK1R) is involved in inflammation and pain transmission. This pathophysiolo
Publikováno v:
Molecules
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d7a9da23de08d1c5007ceb076b0e6
https://doi.org/10.5167/uzh-210190
https://doi.org/10.5167/uzh-210190
Publikováno v:
Science Advances
Human oxytocin receptor structure reveals the basis for ligand recognition and allosteric modulation by lipids and ions.
The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin
The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin
The parathyroid hormone 1 receptor (PTH1R) is a major regulator of mineral ion homeostasis and bone metabolism and is thus considered an attractive drug target for the treatment of disorders in calcium metabolism and bone-related diseases such as ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8e36bbdc07cc8bc225e5b6dd476ed0
https://doi.org/10.5167/uzh-181173
https://doi.org/10.5167/uzh-181173
Autor:
Prakash Rucktooa, Janosch Ehrenmann, Jendrik Schöppe, Marco Schütz, Christoph Klenk, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes. Here we report high-resolution crystal struc
Autor:
Pascal Egloff, Christoph Klenk, Lutz Kummer, Jendrik Schöppe, Andreas Plückthun, Erik Sedlák, Matthias Hillenbrand, Janosch Ehrenmann, Gabriela Nagy-Davidescu, Marco Schütz
Publikováno v:
Scientific Reports
Despite recent successes, many G protein-coupled receptors (GPCRs) remained refractory to detailed molecular studies due to insufficient production yields, even in the most sophisticated eukaryotic expression systems. Here we introduce a robust metho
Publikováno v:
Scientific Reports
Structural and biophysical studies as well as drug screening approaches on G protein-coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties and low expression yields of this largest class of integral membrane proteins