Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Janos Zempleni"'
Autor:
Deborah Fratantonio, Javaria Munir, Jiang Shu, Katherine Howard, Scott R. Baier, Juan Cui, Janos Zempleni
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
Small extracellular vesicles (sEVs) and their RNA cargo in milk are bioavailable in humans, pigs, and mice, and their dietary depletion and supplementation elicits phenotypes. Little is known about the content and biological activity of sEVs in foods
Externí odkaz:
https://doaj.org/article/a305c5f5b3564c3fab2fb346c87c9766
Publikováno v:
BMC Nutrition, Vol 8, Iss 1, Pp 1-6 (2022)
Abstract Background Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities an
Externí odkaz:
https://doaj.org/article/8233c02bf30f4ab4a3ca8b9bfb76f029
Autor:
Fang Zhou, Pearl Ebea, Ezra Mutai, Haichuan Wang, Sonal Sukreet, Shya Navazesh, Haluk Dogan, Wenhao Li, Juan Cui, Peng Ji, Denise M. O. Ramirez, Janos Zempleni
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Human milk contains large amounts of small extracellular vesicles (sEVs) and their microRNA cargos, whereas infant formulas contain only trace amounts of sEVs and microRNAs. We assessed the transport of sEVs across the blood-brain barrier (BBB) and s
Externí odkaz:
https://doaj.org/article/d8c92f9393424d439c15b02cb2a19285
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0265539 (2022)
Holocarboxylase synthetase (HLCS) catalyzes the biotinylation of five distinct biotin-dependent carboxylases and perhaps chromatin proteins. HLCS deficiency causes multiple carboxylase deficiency which results in fatal consequences unless patients ar
Externí odkaz:
https://doaj.org/article/69ef244249e34fdba2692e78ef1aa50b
Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
Autor:
Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs, proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be
Externí odkaz:
https://doaj.org/article/d1aac8aef5bf4e3f9c8e1dd99276ab17
Autor:
Janos Zempleni
Publikováno v:
Genes & Nutrition, Vol 12, Iss 1, Pp 1-4 (2017)
Abstract Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line of research is slowed by a contr
Externí odkaz:
https://doaj.org/article/3a4b0b522811491fac4cf0086bd31426
Autor:
Hailey A. Parry, C. Brooks Mobley, Petey W. Mumford, Matthew A. Romero, Cody T. Haun, Yufeng Zhang, Paul A. Roberson, Janos Zempleni, Arny A. Ferrando, Ivan J. Vechetti, John J. McCarthy, Kaelin C. Young, Michael D. Roberts, Andreas N. Kavazis
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The current study investigated how bovine milk extracellular vesicles (EVs) affected rotarod performance and biomarkers of skeletal muscle physiology in young, growing rats. Twenty-eight-day Fisher 344 rats were provided an AIN-93G-based diet for 4 w
Externí odkaz:
https://doaj.org/article/5f7e87d629b94348848678969206a4e9
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0140587 (2015)
MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Compelling evidences of microRNAs from rice,
Externí odkaz:
https://doaj.org/article/08c370d38ea84e1b88f757da94145e06
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128089 (2015)
With the advent of high throughput technology, a huge amount of microRNA information has been added to the growing body of knowledge for non-coding RNAs. Here we present the Dietary MicroRNA Databases (DMD), the first repository for archiving and ana
Externí odkaz:
https://doaj.org/article/8aade7d061d540458e0e6e077cb66119
Autor:
Nina A Filenko, Carol Kolar, John T West, S Abbie Smith, Yousef I Hassan, Gloria E O Borgstahl, Janos Zempleni, Yuri L Lyubchenko
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16299 (2011)
Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription. It has been shown that biotinylation of histone H4 at lysine-12 in histone H4 (K12Bio-H4) is associated with repression of a
Externí odkaz:
https://doaj.org/article/2bf088bb4d40402b9f62ad9120e47f6e