Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Janos Pitlik"'
Autor:
Cynthia A. Gates, Kai Lin, Govinda Rao, Murcko Mark A, Chao Lin, John H. Van Drie, Yunyi Wei, John Maxwell, Wayne C. Schairer, Gurudatt Chandorkar, Kevin M. Cottrell, Janos Pitlik, Robert B. Perni, Yu-Ping Luong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3406-3411
Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdfc4cf3109ab7123b112b53c078f21
https://doi.org/10.1016/j.bmcl.2007.03.090
https://doi.org/10.1016/j.bmcl.2007.03.090
Autor:
Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
Publikováno v:
Letters in Drug Design & Discovery. 2:497-502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d420d4ea1640c769a11c7300ffa8634
https://doi.org/10.2174/157018005774479203
https://doi.org/10.2174/157018005774479203
Autor:
Kai Lin, Joseph L. Kim, Yu-Ping Luong, Janos Pitlik, Wayne C. Schairer, Chao Lin, Roger D. Tung, Robert B. Perni, John A. Thomson, John Maxwell, Luc J. Farmer, Kevin M. Cottrell, Murcko Mark A, Lawrence F. Courtney, Cynthia A. Gates, John J. Court, John H. Van Drie, David D. Deininger, Wilson Keith P, B. Govinda Rao, Scott L. Harbeson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1939-1942
We recently described the identification of an optimized α-ketoamide warhead for our series of HCV NS3·4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P2. These compounds show except
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee870e2ad12957f02ea4352f74bcbb2
https://doi.org/10.1016/j.bmcl.2004.01.078
https://doi.org/10.1016/j.bmcl.2004.01.078
Autor:
Ethan O'malley, Yunyi Wei, Yu-Ping Luong, John H. Van Drie, Lawrence F. Courtney, Scott L. Harbeson, Janos Pitlik, Kai Lin, Roger D. Tung, Young-Choon Moon, Shawn D. Britt, Chao Lin, Luc J. Farmer, B. Govinda Rao, John J. Court, Cynthia A. Gates, John A. Thomson, David D. Deininger, Robert B. Perni, Rhonda B. Levin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1441-1446
The α-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3·4A protease inhibitors. Structure–activity relationships and prime side optimization are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56535e42d42b9915dbd7e2607e21e42a
https://doi.org/10.1016/j.bmcl.2004.01.022
https://doi.org/10.1016/j.bmcl.2004.01.022
Autor:
Rhonda B. Levin, Luc J. Farmer, Robert B. Perni, Joseph L. Kim, Janos Pitlik, B. Govinda Rao, J. A. Landro, Wayne C. Schairer, Roger D. Tung, Shawn D. Britt, Cynthia A. Gates, David D. Deininger, John A. Thomson, John H. Van Drie, Lawrence F. Courtney, John Court, Ethan O'malley, Scott L. Harbeson, Yu-Ping Luong, Yunyi Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4059-4063
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91046b82077f4245c43e468a535b331b
https://doi.org/10.1016/j.bmcl.2003.08.050
https://doi.org/10.1016/j.bmcl.2003.08.050
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320adad86e567964c14efb4672af45a7
https://doi.org/10.1002/chin.199122293
https://doi.org/10.1002/chin.199122293
Autor:
Christopher J. Schofield, R. M. Adlington, Simon W. Leppard, Wendy J. Sobey, Mark E. Wood, Jack E. Baldwin, Janos Pitlik, Nicholas P. Crouch, John W. Keeping
Publikováno v:
ChemInform. 23
Cyclopropyl substituted cephalosporin analogues were prepared and evaluated as substrates for the FeII/α-ketoglutarate dependent oxygenase, DAOC–DAC synthase; the first example of catalytic product formation from a Cyclopropyl ring cleavage pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494e2d411bd643a0c1dd7aa536686e61
https://doi.org/10.1002/chin.199210297
https://doi.org/10.1002/chin.199210297
Autor:
John W. Keeping, Christopher J. Schofield, Nicholas P. Crouch, Simon W. Leppard, R. M. Adlington, Jack E. Baldwin, Wendy J. Sobey, Mark E. Wood, Janos Pitlik
Publikováno v:
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS. (11)
Cyclopropyl substituted cephalosporin analogues were prepared and evaluated as substrates for the Fe II/α-ketoglutarate dependent oxygenase, DAOC-DAC synthase; the first example of catalytic product formation from a Cyclopropyl ring cleavage pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d15b19d14a130012b87165c0b5cd67
http://ora.ox.ac.uk/objects/uuid:6223aea7-a9a1-4a53-abd3-32cab69ae44b
http://ora.ox.ac.uk/objects/uuid:6223aea7-a9a1-4a53-abd3-32cab69ae44b
Publikováno v:
The Journal of antibiotics. 44(1)
In vitro interactions between aztreonam (AZT) and 8 other antibiotics were studied using the agar dilution checkerboard technique against 88 clinical isolates of Escherichia coli, Proteus vulgaris, Serratia marcescens and Pseudomonas aeruginosa. Comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b633f3c6cae9ce0a2d73b79333667dc
https://pubmed.ncbi.nlm.nih.gov/2001979
https://pubmed.ncbi.nlm.nih.gov/2001979