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Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema

Autor: David S. Boyer, 1 Young Hee Yoon, MD, PhD, 2 Rubens Belfort, Jr, MD, PhD, 3 Francesco Bandello, 4 Raj K. Maturi, 5 Albert J. Augustin, 6 Xiao Yan Li, 7 Harry Cui, 7 Yehia Hashad, 7 Scott M. Whitcup, MDThe MEAD Study Group Principal Investigators: Suel Abujamra, James Acton, Fareed Ali, Andrew Antoszyk, Albert J. Augustin, Carl C. Awh, Adiel Barak, Karl Ulrich Bartz Schmidt, Caroline R. Baumal, Rubens Belfort, J.r., Muna Bhende, William Z. Bridges, David M. Brown, Trevor Carmichael, Ken Carnevale, Antonio M. Casella, Tom Chang, Daniel Chechik, San Ni Chen, Lawrence P. Chong, Victor Chong, Joel Corwin, Catherine Creuzot Garcher, Alan Cruess, Mark Daniell, Marcos P. de Avila, Haroldo Vieira de Moraes, Robert G. Devenyi, Bernard H. Doft, Mark Donaldson, Richard Dreyer, Dean Eliott, Harry M. Engel, Jan Ernest, Thomas F. Essman, Philip M. Falcone, Sharon Fekrat, Joseph R. Ferencz, Joao L. Ferreira, Joao Figueira, Ivan Fiser, Bradley Foster, Gregory M. Fox, William R. Freeman, S. P. Garg, Mark Gillies, David Glaser, Burton G. Goldstein, Andre M. V. Gomes, John R. Gonder, Lingam Gopal, Petrus Gous, Amod Gupta, Anurag Gupta, Lawrence Halperin, Dennis Han, Seenu M. Hariprasad, Frank G. Holz, Peter Kaiser, Bohdana Kalvodova, Barrett Katz, Randy S. Katz, Dariusz Kecik, Judianne Kellaway, Itamar Klemperer, Baruch Kuppermann, Paolo Lanzetta, Rosangela Lattanzio, Won Ki Lee, John Lehr, Monique Leys, Isaac Loose, Andrew Lotery, Da Wen Lu, Paul McCartney, Ajit B. Majji, Jose A. Martinez, Pascale Massin, Raj K. Maturi, Ugo Menchini, Geeta Menon, Mark Michels, Edoardo Midena, James Miller, Paul Mitchell, Joseph Moisseiev, Lawrence Morse, Rafael Navarro, Janos Nemeth, Henry Newland, Richard Newsom, John Nichols, Juan Orellana, Nicola Orzalesi, Augusto Paranhos, Robert Park, Susanna Park, Maurizio Battaglia Parodi, Peter R. Pavan, James Peace, Don J. Perez Ortiz, Ayala Pollack, Kim Ramaswamy, Ramakrishna Ratnakaram, Giuseppe Ravalico, Jiri Rehak, Kourous Rezaei, Stanislao Rizzo, Francisco J. Rodriguez Alvira, Jean Paul Romanet, Steven Rose, Richard B. Rosen, Luca Rossetti, Jose Maria Ruiz Moreno, SriniVas Sadda, Kenneth Sall, Dirk Sandner, Alvaro Fernandez Vega Sanz, Gil Sartani, Stefanie Schmickler, Steven D. Schwartz, Y. R. Sharma, Shwu Jiuan Sheu, Michael Singer, Sobha Sivaprasad, Gisele Soubrane, Petr Soucek, Eric H. Souied, Giovanni Staurenghi, Jan Studnicka, Marta Suarez Figueroa, Walter Y. Takahashi, Patrick L. Tsai, Lawrence J. Ulanski, Harvey Uy, Monica Varano, Miroslav Veith, Igor Vicha, Francesco Viola, Linda Visser, Dov Weinberger, Glenn L. Wing, Edmund Wong, Tien Wong, Edward Wylegala, Jiong Yan, Young Hee Yoon, Lucy H. Young, Hyeong G. Yu, Ingrid E. Zimmer Galler, TOGNETTO, DANIELE

Publikováno v: Ozurdex MEAD Study Group & Newsom, R B 2014, ' Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema ', Ophthalmology, vol. 121, no. 10, pp. 1904-1914 . https://doi.org/10.1016/j.ophtha.2014.04.024

Purpose: To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex, DEX implant) 0.7 and 0.35 mg in the treatment of patients with diabetic macular edema (DME).Design: Two randomized, multicenter, masked, sham-controlled, pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac6868a174f5dad2c622dd901451a00
https://doi.org/10.1016/j.ophtha.2014.04.024

Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis

Autor: Stefano Bonini, Alessandro Lambiase, Paolo Rama, Isabella Filatori, Marcello Allegretti, Wendy Chao, Flavio Mantelli, Elisabeth Messmer, Pasquale Aragona, Gerd Geerling, Leonardo Mastropasqua, Rita Mencucci, John Dart, Andrea Leonardi, Jesus Montero, Maurizio Rolando, Thomas Reinhard, Claus Cursiefen, Jaime Etxebarria, Eric Gabison, Jacek P. Szaflik, Nacim Bouheraoua, Maria De La Paz, Maite Sainz de la Maza, Edward Wylegala, Francisco Figueiredo, Paolo Fogagnolo, Parwez Hossain, Katrin Lorenz, Pierre-Yves Robert, José Benitez del Castillo, Catherine Creuzot-Garcher, Friedrich Kruse, François Malecaze, Jesús Merayo-Lloves, Saaeha Rauz, Jorge Alio, Fiona Carley, Ramaesh Kanna, Carina Koppen, Janos Nemeth, Joaquim Neto Murta, Luis Torrao

Publikováno v: Ophthalmology

Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70150406302e70deafbcc0915359576f
http://hdl.handle.net/11570/3126148

Fixation instability, astigmatism, and lack of stereopsis as factors impeding recovery of binocular balance in amblyopia following binocular therapy

Autor: Éva M. Bankó, Mirella Telles Salgueiro Barboni, Katalin Markó, Judit Körtvélyes, János Németh, Zoltán Zs. Nagy, Zoltán Vidnyánszky

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Dichoptic therapy is a promising method for improving vision in pediatric and adult patients with amblyopia. However, a systematic understanding about changes in specific visual functions and substantial variation of effect among patients is

Externí odkaz: https://doaj.org/article/d7bbdd9b961f444cab7d6f39ce9f9e2a