Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs–Donnan Forces, Namely Spreading Depolarization

Autor: Coline L. Lemale, Janos Lückl, Viktor Horst, Clemens Reiffurth, Sebastian Major, Nils Hecht, Johannes Woitzik, Jens P. Dreier

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal battery breakdown called spreading depolarization, or conversely, spreading depolarization is the electrophysiological correlate of the initial, still reversible ph

Externí odkaz: https://doaj.org/article/4e7dfd58161c4cd89af934f5a6ea88c0

Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhage

Autor: Denny Milakara, Cristian Grozea, Markus Dahlem, Sebastian Major, Maren K.L. Winkler, Janos Lückl, Michael Scheel, Vasilis Kola, Karl Schoknecht, Svetlana Lublinsky, Alon Friedman, Peter Martus, Jed A. Hartings, Johannes Woitzik, Jens P. Dreier

Publikováno v: NeuroImage: Clinical, Vol 16, Iss , Pp 524-538 (2017)

In many cerebral grey matter structures including the neocortex, spreading depolarization (SD) is the principal mechanism of the near-complete breakdown of the transcellular ion gradients with abrupt water influx into neurons. Accordingly, SDs are ab

Externí odkaz: https://doaj.org/article/3a13ecccfe834c32a3446ca0551db717

The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy

Autor: Tamás Dóczi, Diána Kuperczkó, Ákos Újvári, Imre Repa, Endre Pál, Péter Halász, Beáta Bóné, Zoltán Tóth, Péter Barsi, Jean Isnard, Miklós Emri, Katalin Borbély, Zsolt Horváth, Vera Juhos, Márton Tóth, Réka Horváth, Ferenc Nagy, Zsolt Vajda, Zsófia Jordán, Dániel Fabó, Csilla Gyimesi, Koichi Hagiwara, Anna Kelemen, Janos Luckl, József Janszky, Attila Fekésházy

Publikováno v: BMC Neurology
BMC Neurology, Vol 21, Iss 1, Pp 1-20 (2021)

Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide additional information for ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d5606cb70ea5759cf9e291e2adbcf8
https://doi.org/10.1186/s12883-021-02352-z

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

Autor: Eun-Jeung Kang, Uldus Khojasteh, Sebastian Major, Jed A. Hartings, Johannes Woitzik, Janos Luckl, Peter Martus, Karl Schoknecht, Vasilis Kola, Ana I Oliveira-Ferreira, Maren K.L. Winkler, Viktor Horst, Coline L. Lemale, Jens P. Dreier

Publikováno v: Brain

Experimental studies indicate that, following focal or global ischaemia, progressive recruitment of neocortical neurons into death begins when spreading depolarization gives way to a negative ultraslow potential. By monitoring patients with subarachn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674457c1cd96d4fa6a98a0af9fa9c498
https://doi.org/10.1093/brain/awy102

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Autor: Erdem Güresir, Sergei A. Kirov, Egill Rostrup, Christoph Drenckhahn, Martyn G. Boutelle, Brian A. MacVicar, Michael Schöll, Andrew I R Maas, Michael Scheel, Daniel Kondziella, Clemens Reiffurth, Johannes Platz, Jason M. Hinzman, Juan Sahuquillo, M. Ross Bullock, Frank Richter, Tomas Watanabe, Ilan Shelef, Kazutaka Sugimoto, Martin Lauritzen, Bart Feyen, Julia S. Bretz, Brandon Foreman, David O. Okonkwo, Eun Jeung Kang, Hartmut Vatter, Markus Dahlem, Anthony J. Strong, Ana I Oliveira-Ferreira, Jens P. Dreier, Nils Hecht, Baptiste Balança, Otto W. Witte, Christina M. Kowoll, Yoash Chassidim, Sharon L. Jewell, Rudolf Graf, Nina Eriksen, Thomas Lieutaud, Gerrit Brinker, Johannes Woitzik, Alon Friedman, Andrew P. Carlson, Nora F. Dengler, Henning Piilgaard, Bente Pakkenberg, Svetlana Lublinsky, Lee S Chung, Maren K.L. Winkler, Gajanan S. Revankar, C. William Shuttleworth, Christian Dohmen, Jan Claassen, Janos Luckl, Delphine Feuerstein, André P. Schulte, Michiyasu Suzuki, Edgar Santos, Michael Reiner, Denny Milakara, Peter Vajkoczy, Jed A. Hartings, Lori Shutter, Sebastian Major, Stéphane Marinesco, Daniel N. Hertle, Martin Fabricius, Michel D. Ferrari, Paul Jahnke, Viktor Horst, Uwe Heinemann, Alois Josef Schiefecker, Oliver W. Sakowitz, Peter Martus, M. Brandon Westover, Cenk Ayata, Renán Sánchez-Porras, Rick M. Dijkhuizen, Kc Brennan, Christian K. Friberg, Norberto Andaluz, R. David Andrew, Karl Schoknecht, Eric Rosenthal, Oscar Herreras, Georg Bohner, Raimund Helbok, Anna Maslarova, Eszter Farkas, Arn M. J. M. van den Maagdenberg

Publikováno v: Journal of Cerebral Blood Flow and Metabolism, 37(5), 1595-1625
Journal of Cerebral Blood Flow and Metabolism, 37(5), 1595–1625. Nature Publishing Group
Journal of cerebral blood flow and metabolism

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad6339be4383c1afbe3013d742caa94
https://europepmc.org/articles/PMC5435289/