Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Janos Fischer"'
Publikováno v:
Journal of medicinal chemistry. 64(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491973f70f97abec32e6f636d5c1a983
https://pubmed.ncbi.nlm.nih.gov/34606261
https://pubmed.ncbi.nlm.nih.gov/34606261
Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug�s discovery an
Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of th
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach
Autor:
János Fischer, Wayne E. Childers
Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route
Publikováno v:
Pharmacology, biochemistry, and behavior. 159
Cannabinoid receptor 1 (CB1R) antagonists have been proven to be effective anti-obesity drugs; however, psychiatric side effects have halted their pharmaceutical development worldwide. Despite the emergence of next generation CB1R blockers, a preclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2037b5e5c675ae9e2414e846c656e6e5
https://pubmed.ncbi.nlm.nih.gov/28666894
https://pubmed.ncbi.nlm.nih.gov/28666894
Autor:
János Fischer, David P. Rotella
The first volume of the book series'Successful Drug Discovery'is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role o
Autor:
Istvan Gyertyan, Bela Kiss, György Szabó, Mónika Vastag, Eva Hegyi, Dóra Payer-Lengyel, Krisztina Vukics, Attila Szemzö, Judit Szikra, Judit Laszy, Janos Fischer, Peter Erdelyi, Balázs Varga
Publikováno v:
Journal of Medicinal Chemistry. 52:4329-4337
Obesity is a major clinical problem in the western world, and many molecular targets have been explored in the search for effective therapeutic agents. One of these, antagonism of the cannabinoid 1 (CB1) receptor, rose to prominence following reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdada94417ac61829f01e55ec7a7ef54
https://doi.org/10.1021/jm900179y
https://doi.org/10.1021/jm900179y
Publikováno v:
Journal of Medicinal Chemistry. 51:142-147
A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Some compounds, for example, (+/-)-2-[4-(5- p-tolyl-3-trifluoromethyl-pyrazole-1-yl)-be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7688391a4f8b71a50adebe458c0a57
https://doi.org/10.1021/jm070821f
https://doi.org/10.1021/jm070821f
Autor:
Janos Fischer
Publikováno v:
Medicinal Chemistry Research. 13:218-227
Analogues play an important role in the evolution of drugs. Of the 350 most frequently used synthetic drugs, only 150 different mechanisms of action are represented indicating that multiple drugs can share common mechanisms. If statistically every se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4913649e4a4f7d669b4f6e6e8b5f3392
https://doi.org/10.1007/s00044-004-0029-3
https://doi.org/10.1007/s00044-004-0029-3