Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Janos Demeter"'
Autor:
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with agi
Externí odkaz:
https://doaj.org/article/1cb547b9df374953936e2d5fd08f29bc
Autor:
Christopher W. Murray, Jennifer J. Brady, Mingqi Han, Hongchen Cai, Min K. Tsai, Sarah E. Pierce, Ran Cheng, Janos Demeter, David M. Feldser, Peter K. Jackson, David B. Shackelford, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
LKB1 tumour suppressor gene is frequently mutated in lung adenocarcinoma. Here the authors show that in genetically engineered mouse models of lung cancer Lkb1 restoration induces growth arrest and drives neoplastic cells toward a more differentiated
Externí odkaz:
https://doaj.org/article/fac054136b674b659d92c440e9e9e2b2
Autor:
Darci Phillips, Magdalena Matusiak, Belén Rivero Gutierrez, Salil S. Bhate, Graham L. Barlow, Sizun Jiang, Janos Demeter, Kimberly S. Smythe, Robert H. Pierce, Steven P. Fling, Nirasha Ramchurren, Martin A. Cheever, Yury Goltsev, Robert B. West, Michael S. Khodadoust, Youn H. Kim, Christian M. Schürch, Garry P. Nolan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.
Externí odkaz:
https://doaj.org/article/185b95b3ae0241efb2f75ef0ed8fba8c
Autor:
Jenny Hsu, Julia Arand, Andrea Chaikovsky, Nancie A. Mooney, Janos Demeter, Caileen M. Brison, Romane Oliverio, Hannes Vogel, Seth M. Rubin, Peter K. Jackson, Julien Sage
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
E2F transcription factors are regulators of cell division and cell fate decisions. Here the authors show that E2F4 is important for proliferation and survival of mouse ESCs, independent of the RB family, and that E2F4 interacts with chromatin regulat
Externí odkaz:
https://doaj.org/article/e3a619fadabb47e3805fe00dc38b37d4
Autor:
Patricia R Nano, Taylor K Johnson, Takamasa Kudo, Nancie A Mooney, Jun Ni, Janos Demeter, Peter K Jackson, James K Chen
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251684 (2021)
ARHGAP36 is an atypical Rho GTPase-activating protein (GAP) family member that drives both spinal cord development and tumorigenesis, acting in part through an N-terminal motif that suppresses protein kinase A and activates Gli transcription factors.
Externí odkaz:
https://doaj.org/article/26c7e95d7e2c4d55b0b5a8130ee17cf1
Autor:
Balyn W Zaro, Joseph J Noh, Victoria L Mascetti, Janos Demeter, Benson George, Monika Zukowska, Gunsagar S Gulati, Rahul Sinha, Ryan A Flynn, Allison Banuelos, Allison Zhang, Adam C Wilkinson, Peter Jackson, Irving L Weissman
Publikováno v:
eLife, Vol 9 (2020)
The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healthy blood supply; imbalances underlie hematological diseases. The importance of HSCs and their progenitors have led to their extensive characterizatio
Externí odkaz:
https://doaj.org/article/400aec0da9464b239e577082fb119d11
Autor:
Heather E. desJardins-Park, AB, Shamik Mascharak, BA, Michael Januszyk, MD, PhD, Kellen Chen, PhD, Michael F. Davitt, MD, Janos Demeter, PhD, Dominic Henn, MD, Michelle Griffin, MD, PhD, Clark A. Bonham, BA, Nancie Mooney, PhD, Ran Cheng, BS, Peter K. Jackson, PhD, Derrick C. Wan, MD, Geoffrey C. Gurtner, MD, Michael T. Longaker, MD, MBA
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 9, Iss 7S, Pp 2-3 (2021)
Purpose: Scarring in the mouse dorsal dermis is mediated by pro-fibrotic, Engrailed-1 lineage-positive fibroblasts (EPFs). We recently showed that mechanotransduction blockade (YAP inhibition, using the drug verteporfin), results in complete wound re
Externí odkaz:
https://doaj.org/article/a454e96cb6564f88b7902ecd12567506
Autor:
Giltae Song, Benjamin J A Dickins, Janos Demeter, Stacia Engel, Jennifer Gallagher, Kisurb Choe, Barbara Dunn, Michael Snyder, J Michael Cherry
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0129184 (2015)
Externí odkaz:
https://doaj.org/article/4057147613aa444fa68e3c2865f2d3d0
Autor:
Giltae Song, Benjamin J A Dickins, Janos Demeter, Stacia Engel, Jennifer Gallagher, Kisurb Choe, Barbara Dunn, Michael Snyder, J Michael Cherry
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120671 (2015)
The characterization and public release of genome sequences from thousands of organisms is expanding the scope for genetic variation studies. However, understanding the phenotypic consequences of genetic variation remains a challenge in eukaryotes du
Externí odkaz:
https://doaj.org/article/319dd31e7258420c8ebb82cc2d5c9e6f
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