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pro vyhledávání: '"Jano D Giacobini"'
Autor:
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194414 (2018)
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effec
Externí odkaz:
https://doaj.org/article/bc6b7c684378410db0b95b3b96ab786f
Autor:
Martin Haupt-Jorgensen, Laurits J. Holm, Jane Preuss Hasselby, Jano D. Giacobini, Karsten Buschard, Mesut Bilgin
Publikováno v:
Diabetologia
Holm, L J, Haupt-jorgensen, M, Giacobini, J D, Hasselby, J P, Bilgin, M & Buschard, K 2019, ' Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice ', Diabetologia, vol. 62, no. 12, pp. 2262-2272 . https://doi.org/10.1007/s00125-019-04973-z
Holm, L J, Haupt-jorgensen, M, Giacobini, J D, Hasselby, J P, Bilgin, M & Buschard, K 2019, ' Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice ', Diabetologia, vol. 62, no. 12, pp. 2262-2272 . https://doi.org/10.1007/s00125-019-04973-z
Aims/hypothesis Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d62d7bf2241fac3367e18ca2ed1419
http://europepmc.org/articles/PMC6861358
http://europepmc.org/articles/PMC6861358