Vγ9Vδ2 T cells use a combination of mechanisms to limit the spread of the pathogenic bacteria Brucella

Autor: Jean-Pierre Liautard, Virginie Lafont, Jane Oliaro, Sherri Dudal, Jean-Baptiste Andrault, Janny Liautard

Publikováno v: Journal of Leukocyte Biology. 77:652-660

Human Vγ9Vδ2 T cells pay a crucial role in early immune response to intracellular pathogens. In brucellosis infection, this population of cells is drastically increased in the peripheral blood of patients during the acute phase of infection. In vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eca43e000a1e8dae1bac83180b874bf
https://doi.org/10.1189/jlb.0704433

The innate immune response against Brucella in humans

Autor: Jane Oliaro, Virgine Lafont, Antoine Gross, Jean-Pierre Liautard, Jacques Dornand, Janny Liautard

Publikováno v: Veterinary Microbiology
Veterinary Microbiology, Elsevier, 2002, 90 (1-4), pp.383-94. ⟨10.1016/S0378-1135(02)00223-7⟩

Pathogens have developed different strategies to survive and multiply within their host. Among them is the ability to control phagocyte apoptosis while another is to affect the expression of cytokines which is necessary for a normal protective functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a253c52b6c9a22254462ea1b5737a2
https://doi.org/10.1016/s0378-1135(02)00223-7

Isopentenyl Pyrophosphate, a Mycobacterial Non-peptidic Antigen, Triggers Delayed and Highly Sustained Signaling in Human γδ T Lymphocytes without Inducing Down-modulation of T Cell Antigen Receptor

Autor: Magali Sablé-Teychené, Yannis Sainte-Marie, Janny Liautard, Virginie Lafont, Jean Favero

Publikováno v: Journal of Biological Chemistry. 276:15961-15967

The Vgamma9Vdelta2 T cell subset, which represents up to 90% of the circulating gammadelta T cells in humans, was shown to be activated, via the T cell receptor (TcR), by non-peptidic phosphorylated small organic molecules. These phosphoantigens, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ee43bf7da06b5285a8aaf95f1e53a4
https://doi.org/10.1074/jbc.m008684200

The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1

Autor: Virginie Lafont, Arian Laurence, Emmanuelle Astoul, Janny Liautard, Doreen A. Cantrell

Publikováno v: FEBS Letters. 486:38-42

The present study has explored T cell antigen receptor-regulated serine kinases in human T cells. The results identify two phosphatidylinositol 3-kinase (PI3K)-controlled serine kinases operating downstream of the T cell receptor (TCR) in primary T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdd0b2eeea321f50f2578b5b30999a3
https://doi.org/10.1016/s0014-5793(00)02235-3

IFN-α Is a Survival Factor for Human Myeloma Cells and Reduces Dexamethasone-Induced Apoptosis

Autor: Martine Ferlin-Bezombes, Michel Jourdan, Janny Liautard, Jean Brochier, Jean-François Rossi, Bernard Klein

Publikováno v: The Journal of Immunology. 161:2692-2699

IFN-α is used as a maintenance therapy in patients with multiple myeloma, but its benefit is a matter of controversy. In vitro studies show that IFN-α can both stimulate and inhibit myeloma cell proliferation. We have tested the effect of IFN-α on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8805b009a07b0751ea59a98259ed45d8
https://doi.org/10.4049/jimmunol.161.6.2692