Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jannik Prasuhn"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and dist
Externí odkaz:
https://doaj.org/article/3e1e5478bbd8409dbea24fc808d2075d
Autor:
Tatiana Usnich, Björn Hauptmann, Henrike Hanssen, Jannik Prasuhn, Alexander Balck, Max Borsche, Vera Tadic, Annika Klee, Greta Noblejas-Sanchez, Eva-Juliane Vollstedt, Christine Klein, Norbert Brüggemann, Meike Kasten, EPIPARK Study Group
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-5 (2023)
Abstract Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. He
Externí odkaz:
https://doaj.org/article/0e542be06b6047ee9ce7d1e0a8b98baa
Autor:
Jannik Prasuhn, Martin Göttlich, Friederike Gerkan, Sofia Kourou, Britt Ebeling, Meike Kasten, Henrike Hanssen, Christine Klein, Norbert Brüggemann
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-11 (2022)
Abstract Background The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mechanisms are likely int
Externí odkaz:
https://doaj.org/article/39d377b7c4f0420897facf52fda2c7a5
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1411 (2023)
There is a pressing need for disease-modifying therapies in patients suffering from neurodegenerative diseases, including Parkinson’s disease (PD). However, these disorders face unique challenges in clinical trial designs to assess the neuroprotect
Externí odkaz:
https://doaj.org/article/b5df5a071a4440e58429136c0c9c81b1
Autor:
Jannik Prasuhn, Norbert Brüggemann
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-13 (2021)
Abstract Background Remarkable advances have been reached in the understanding of the genetic basis of Parkinson’s disease (PD), with the identification of monogenic causes (mPD) and a plethora of gene loci leading to an increased risk for idiopath
Externí odkaz:
https://doaj.org/article/3bda446e0b2b4f4ca796ce426a080f86
Autor:
Jost L. Lauermann, Jan A. M. Sochurek, Pauline Plöttner, Florian Alten, Meike Kasten, Jannik Prasuhn, Norbert Brüggemann, Mahdy Ranjbar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract To evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson’s disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated P
Externí odkaz:
https://doaj.org/article/3bb72ab072714c29bcd2a79274e2097c
Autor:
Juliane Münch, Jannik Prasuhn, Lucia Laugwitz, Cheuk-Wing Fung, Brian H.-Y. Chung, Marcello Bellusci, Ertan Mayatepek, Dirk Klee, Felix Distelmaier
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 718 (2023)
Coenzyme Q10 (CoQ10) is an endogenously synthesized lipid molecule. It is best known for its role as a cofactor within the mitochondrial respiratory chain where it functions in electron transfer and ATP synthesis. However, there are many other cellul
Externí odkaz:
https://doaj.org/article/32df7fb6fc4f4a64a575318dfcfb0499
Publikováno v:
Neurological Research and Practice, Vol 2, Iss 1, Pp 1-5 (2020)
Abstract Introduction The presence of motor signs and symptoms in Parkinson’s disease (PD) is the result of a long-lasting prodromal phase with an advancing neurodegenerative process. The identification of PD patients in an early phase is, however,
Externí odkaz:
https://doaj.org/article/c1299611f72e44c99ee1abbb2ae4cbf7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13678 (2022)
The underlying causes of Parkinson’s disease are complex, and besides recent advances in elucidating relevant disease mechanisms, no disease-modifying treatments are currently available. One proposed pathophysiological hallmark is mitochondrial dys
Externí odkaz:
https://doaj.org/article/44b7055d38b64f76ae9e615ac5f5c79f
Autor:
Jannik Prasuhn, Alexander Neumann, Robert Strautz, Shalida Dreischmeier, Felicitas Lemmer, Henrike Hanssen, Marcus Heldmann, Peter Schramm, Norbert Brüggemann
Publikováno v:
Brain and Behavior, Vol 11, Iss 7, Pp n/a-n/a (2021)
Abstract Background With conventional MRI, no Parkinson's disease (PD)‐specific abnormalities can be detected. However, there is a critical need for accompanying neuroimaging markers to guide the diagnosis. With high‐resolution susceptibility‐w
Externí odkaz:
https://doaj.org/article/56b4b3e818824f50bb3c1ad7d106bbe7