Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jannick Theobald"'
Autor:
Mohamed A. Abu el Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner, Stefan Wölfl
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-18 (2018)
Abstract Background We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the current study, we i
Externí odkaz:
https://doaj.org/article/a3cd4fea2f9942a9bc7fc598ae137830
Autor:
Axel R Göhring, Stefanie Reuter, Joachim H Clement, Xinlai Cheng, Jannick Theobald, Stefan Wölfl, Ralf Mrowka
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174912 (2017)
PURPOSE:Oct4 was reported to be one of the most important pluripotency transcription factors in the biology of stem cells including cancer stem cells, and progressed malignant cells. Here we report the investigation of gene expression control of Oct4
Externí odkaz:
https://doaj.org/article/feceb3ff4204462db708c4b2ed6c2f0c
Autor:
Yasamin Dabiri, Alice Schmid, Jannick Theobald, Biljana Blagojevic, Wojciech Streciwilk, Ingo Ott, Stefan Wölfl, Xinlai Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3964 (2018)
The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have demonstrated the important role of p38 both as a regulator and a sensor of cellular reactive
Externí odkaz:
https://doaj.org/article/b7a02fdde0b94f43b74637275377cb15
Autor:
Jan H. Reiling, Tatiana I. Ignashkova, Stefan Wölfl, Hamed Alborzinia, Mathieu Gendarme, Francesca R. Dejure, Ralph K. Lindemann, Jannick Theobald
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-15 (2018)
Communications Biology
Communications Biology
Cytotoxic activities of several Golgi-dispersing compounds including AMF-26/M-COPA, brefeldin A and golgicide A have previously been shown to induce autophagy or apoptosis. Here, we demonstrate that these Golgi disruptors also trigger ferroptosis, a
Autor:
Ingo Ott, Stefanie Haeberle, Rodrigo A. Gama-Brambila, Andrea Savarino, Marina Lusic, Uttara Basu, Claudia Schmidt, Shahrouz Ghafoory, Miguel A. Andrade-Navarro, Eva Hadaschik, Annika Timm, Nikolaos Tsopoulidis, Oliver T. Fackler, Stefan Wölfl, Iart Luca Shytaj, Andrea S. Bauer, Katerina Taškova, Jörg D. Hoheisel, Jannick Theobald, Xinlai Cheng, Jessica Wölker
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Gold compounds have a long history of use as immunosuppressants, but their precise mechanism of action is not completely understood. Using our recently developed liver-on-a-chip platform we now show that gold compounds containing planar N-heterocycli
Autor:
Priska Hakenberg, Matthias P. Ebert, Jannick Theobald, Stefan Wölfl, Hagen Heinlein, H Gaitantzi, Katja Breitkopf-Heinlein, Ulrike Subotic, Steffan Loff, C Cai
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 66:e28-e35
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in many polyvinylchloride medical devices and is washed out easily. Thereby critically ill infants can become exposed to DEHP concentrations significantly exceeding the recommended threshold. We
Autor:
Edda Klipp, Stefan Wölfl, Ralf Mrowka, Xinlai Cheng, Judith A. H. Wodke, Holger Becker, H Gaitantzi, Steven Dooley, Katja Breitkopf-Heinlein, Guangqi Song, Ali Ghanem, Jannick Theobald
Publikováno v:
Archives of Toxicology. 92:1133-1149
The metabolic activity of hepatocytes is a central prerequisite for drug activity and a key element in drug-drug interaction. This central role in metabolism largely depends on the activity of the cytochrome P450 (CYP450) enzyme family, which is not
Autor:
Ralf Mrowka, Ali Ghanem, Katerina Taškova, Patrick Wallisch, Manuela Haltmeier, Stefanie Reuter, Amin A. Banaeiyan, Miguel A. Andrade-Navarro, Stefan Wölfl, Jannick Theobald, Holger Becker, Andreas Kurtz, Xinlai Cheng
Publikováno v:
ACS Biomaterials Science & Engineering. 4:78-89
Advances in organ-on-chip technologies for the application in in vitro drug development provide an attractive alternative approach to replace ethically controversial animal testing and to establish a basis for accelerated drug development. In recent
Autor:
Jannick Theobald, Tijen Duvaci, Hamed Alborzinia, Jörg D. Hoheisel, Johannes Fredebohm, Arianeb Mehrabi, Xinlai Cheng, Pavlo Holenya, Karl Heinz Merz, Gerhard Eisenbrand, Mohammadreza Hafezi, Shahrouz Ghafoory, Arash Saffari, Stefan Wölfl, Roya Rafiee, Jee Young Kim
Publikováno v:
Molecular Oncology. 10:806-824
Pancreatic ductal adenocarcinoma (PDAC) clinically has a very poor prognosis. No small molecule is available to reliably achieve cures. Meisoindigo is chemically related to the natural product indirubin and showed substantial efficiency in clinical c
Autor:
Jannick Theobald, Mohamed A. Abu el Maaty, Nico Kusterer, Bernhard Wetterauer, Michael Wink, Xinlai Cheng, Stefan Wölfl
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Organ-on-chip platforms provide models that allow the representation of human physiological processes in cell-based miniaturized systems. Potential pre-clinical applications include drug testing and toxicity studies. Here we describe the use of a mul