Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice

Autor: Garazi Pena Alzua, Anne Finne Pihl, Anna Offersgaard, Carlos Rene Duarte Hernandez, Zhe Duan, Shan Feng, Ulrik Fahnøe, Christina Sølund, Nina Weis, Mansun Law, Jannick C Prentoe, Jan Pravsgaard Christensen, Jens Bukh, Judith Margarete Gottwein

Publikováno v: Alzua, G P, Pihl, A F, Offersgaard, A, Duarte Hernandez, C R, Duan, Z, Feng, S, Fahnøe, U, Sølund, C, Weis, N, Law, M, Prentoe, J C, Christensen, J P, Bukh, J & Gottwein, J M 2023, ' Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice ', Gut, vol. 72, no. 3, pp. 560-572 . https://doi.org/10.1136/gutjnl-2021-326323

ObjectiveA prophylactic vaccine is needed to control the HCV epidemic, with genotypes 1–3 causing >80% of worldwide infections. Vaccine development is hampered by HCV heterogeneity, viral escape including protection of conserved neutralising epitop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2ece0610c4efacfcb6628adc04150c
https://doi.org/10.1136/gutjnl-2021-326323

Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice.

Autor: Alzua, Garazi Pena, Pihl, Anne Finne, Offersgaard, Anna, Hernandez, Carlos Rene Duarte, Zhe Duan, Shan Feng, Fahnøe, Ulrik, Sølund, Christina, Weis, Nina, Law, Mansun, Prentoe, Jannick C., Christensen, Jan Pravsgaard, Bukh, Jens, Gottwein, Judith Margarete

Publikováno v: Gut; Mar2023, Vol. 72 Issue 3, p560-572, 13p