Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jannette Wober"'
Autor:
Heba E. Elnakib, Marian M. Ramsis, Nouran O. Albably, Merna A. Vector, Jan J. Weigand, Kai Schwedtmann, Jannette Wober, Oliver Zierau, Günter Vollmer, Ashraf H. Abadi, Nermin S. Ahmed
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12575 (2021)
Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ERα) agonists or antagonists depending on the target issue. Tamoxifen (TAM) (a non-steroidal triphenylethylene derivative) was the first SERM approved as anti-estrogen for the
Externí odkaz:
https://doaj.org/article/02806fab66f74a54bdf6c60bef1b845b
Autor:
Rahma M. Elbagoury, Miriam A. Shenouda, Heba E. Elnakib, Jannette Wober, Ashraf H. Abadi, Nermin S. Ahmed
Publikováno v:
Bioorganic chemistry. 131
Tamoxifen (TAM) is used in treatment of hormonal dependent breast cancer, both in premenopausal and postmenopausal women. TAM is intrinsically metabolized by CYP450 enzymes to more active metabolites. Recent reports identified CYP2D6, an enzyme invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e39cdf0d788ed405f1f691ce44d7bd
https://pubmed.ncbi.nlm.nih.gov/36455483
https://pubmed.ncbi.nlm.nih.gov/36455483
Publikováno v:
ChemMedChem. 17(7)
Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) with potential clinical benefits for all stages of breast cancer. TAM is primarily metabolized to more potent metabolites via polymorphic CYP2D6. This affects the clinical outcome of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854a860f8cca8e68f813a257e1069345
https://pubmed.ncbi.nlm.nih.gov/35076180
https://pubmed.ncbi.nlm.nih.gov/35076180
Autor:
María Victoria Zanardi, María Paula Gastiazoro, Georg Kretzschmar, Jannette Wober, Günter Vollmer, Jorgelina Varayoud, Milena Durando, Oliver Zierau
Publikováno v:
Molecular and cellular endocrinology. 543
Hops (Humulus lupulus) is used as an alternative to hormone replacement therapy due to the phytoestrogen, 8-prenylnaringenin (8-PN). To examine the potential risks/benefits of hops extract and its compounds (8-PN and 6-prenylnaringenin, 6-PN), we aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c929479f8daafa9456ffe31ef6fe7ddf
https://pubmed.ncbi.nlm.nih.gov/34965452
https://pubmed.ncbi.nlm.nih.gov/34965452
Publikováno v:
Toxicology 456(2021), 152771
Lanthanide (Ln) exposure poses a serious health risk to animals and humans. In this study, we investigated the effect of 10−9–10−3 M La, Ce, Eu, and Yb exposure onto the viability of rat renal NRK-52E cells in dependence on Ln concentration, ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a322c0f9b89e61cef749ddd2f34be258
https://www.hzdr.de/publications/Publ-31698-1
https://www.hzdr.de/publications/Publ-31698-1
Autor:
Jannette Wober, Nermin S. Ahmed
Publikováno v:
Drug development researchREFERENCES. 81(4)
Tamoxifen (TAM) is currently the endocrine treatment of choice for all stages of breast cancer; it has proven success in ER positive and ER negative patients. TAM is activated by endogenous CYP450 enzymes to the more biologically active metabolites 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5648e8ca865630e00d9b94bf3b08be
https://pubmed.ncbi.nlm.nih.gov/31916635
https://pubmed.ncbi.nlm.nih.gov/31916635
Publikováno v:
Ecotoxicology and Environmental Safety 173(2019), 469-481
Exposure to lanthanides (Ln) poses a serious health risk to animals and humans. Since Ln are mainly excreted with urine, we investigated the effect of La, Ce, Eu, and Yb exposure on renal rat NRK-52E and human HEK-293 cells for 8, 24, and 48 h in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed9fa7b0d52dfc78631daa1e8b5f840
https://pubmed.ncbi.nlm.nih.gov/30802736
https://pubmed.ncbi.nlm.nih.gov/30802736
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 127:428-434
Knockout of the Cyp-19 gene (aromatase) renders mice to have insufficient endogenous estrogen production and contributes to the development of symptoms related the metabolic syndrome, including excess adiposity and insulin resistance. This study comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544840cf5345fb10717391cd2ab55325
https://doi.org/10.1016/j.jsbmb.2011.05.004
https://doi.org/10.1016/j.jsbmb.2011.05.004
Autor:
Niki Eliza Arapogianni, Jana Hempel, Alexios-Leandros Skaltsounis, Nicole Hunger, Claudia Kühn, Maria Halabalaki, Jannette Wober, Günter Vollmer
Publikováno v:
Planta Medica. 77:346-353
A number of medicinal/culinary herbs have been reported to improve glucose metabolism and to yield hypoglycemic effects in patients with diabetes. Since stimulation of insulin sensitivity appears to be a potential mechanism, peroxisome proliferator-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5297251fb2886344aeafd26b9b36eb18
https://doi.org/10.1055/s-0030-1250382
https://doi.org/10.1055/s-0030-1250382
Autor:
Tobias Richter, Günter Vollmer, Anett Jandausch, Reinhard Rettenberger, Frank Möller, Carmen Weigt, Oliver Zierau, Catharina Unger, Jannette Wober, Marietta Kaszkin-Bettag
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 107:191-201
The special extract ERr 731 from the roots of Rheum rhaponticum is the major constituent of Phytoestrol N which is used for the treatment of climacteric symptoms in menopausal women. However, the molecular mode of action of ERr 731 was unknown. For t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8426a6d0e0515020d1980bd9eb3e06a9
https://doi.org/10.1016/j.jsbmb.2007.04.002
https://doi.org/10.1016/j.jsbmb.2007.04.002