Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Jannette M. Dufour"'
Autor:
Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1650 (2023)
Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte
Externí odkaz:
https://doaj.org/article/b54c88465c0646c0ae6edfd99d7c02ae
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The testis must create and maintain an immune privileged environment to protect maturing germ cells from autoimmune destruction. The establishment of this protective environment is due, at least in part, to Sertoli cells. Sertoli cells line the semin
Externí odkaz:
https://doaj.org/article/ecdf1470c36b457c84e1781a5eb6af85
Autor:
Gurvinder Kaur, Kandis Wright, Payal Mital, Taylor Hibler, Jonathan M. Miranda, Lea Ann Thompson, Katelyn Halley, Jannette M. Dufour
Publikováno v:
Cell Transplantation, Vol 29 (2020)
The acute cell-mediated immune response presents a significant barrier to xenotransplantation. Immune-privileged Sertoli cells (SC) can prolong the survival of co-transplanted cells including xenogeneic islets, hepatocytes, and neurons by protecting
Externí odkaz:
https://doaj.org/article/f1f27819ae014b9ca9b9cda5123192b8
Autor:
Rachel L. Washburn, Karl Mueller, Gurvinder Kaur, Tanir Moreno, Naima Moustaid-Moussa, Latha Ramalingam, Jannette M. Dufour
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 270 (2021)
Diabetes mellitus (DM) is a complex metabolic disease affecting one-third of the United States population. It is characterized by hyperglycemia, where the hormone insulin is either not produced sufficiently or where there is a resistance to insulin.
Externí odkaz:
https://doaj.org/article/32e94a0ffcf24e8186a285326e8ead00
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Xenotransplantation has vast clinical potential but is limited by the potent immune responses generated against xenogeneic tissue. Immune-privileged Sertoli cells (SCs) survive xenotransplantation long term (≥90 days) without immunosuppression, mak
Externí odkaz:
https://doaj.org/article/a5b834d3413c4f9db36f728e3ec6f50e
Autor:
Katelyn Halley, Emily L. Dyson, Gurvinder Kaur, Payal Mital, Peter M. Uong, Brinda Dass, Sherry N. Crowell, Jannette M. Dufour
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Immune-privileged Sertoli cells survive long term after allogeneic or xenogeneic transplantation without the use of immunosuppressive drugs, suggesting they could be used as a vehicle to deliver therapeutic proteins. As a model to test this, we engin
Externí odkaz:
https://doaj.org/article/ba597af5de054a29a1ae5de8136b7d3f
Autor:
Jannette M. Dufour, Brinda Dass, Katie R. Halley, Gregory S. Korbutt, Doreen E. Dixon, Ray V. Rajotte
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell lin
Externí odkaz:
https://doaj.org/article/43b0575ae3174df9944f98b13129e2a5
Autor:
Jannette M. Dufour, Sarah J. Lord, Tatsuya Kin, Gina R. Rayat, Doreen E. Dixon, R. Chris Bleackley, Gregory S. Korbutt, Ray V. Rajotte
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Sertoli cells (SC) protect islet allografts from immune destruction in diabetic rodents. In this study, we examined the difference between successful and rejected islet/SC cografts in order to further improve this procedure for optimal extension of i
Externí odkaz:
https://doaj.org/article/cea3cf4bf4154abe957e60494bfd0bed
Autor:
Jannette M. Dufour, Paul Gores, Richelle Hemendinger, Dwaine F. Emerich, Craig R. Halberstadt Ph.D.
Publikováno v:
Cell Transplantation, Vol 13 (2004)
Gene therapy involves the manipulation of genetic material to replace defective or deficient proteins to restore function in disease states. These genes are introduced into cells by mechanical, chemical, and biological approaches. To date, cell-based
Externí odkaz:
https://doaj.org/article/9a4e0cff3d2641649b6be3c2d45b0bd7
Publikováno v:
Cell Transplantation, Vol 11 (2002)
Sertoli cells (SC) play a critical role in the maintenance of the immunoprivileged environment of the testis. We hypothesized that preengrafting SC would allow one to develop a vascularized immunoprivileged ectopic site that provides protection for m
Externí odkaz:
https://doaj.org/article/d9971799e6894f14be7d0a72e8977915