Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Janne Marvola"'
Publikováno v:
International Journal of Pharmaceutics. 349:24-29
The fate of two colon-specific formulations developed in our previous study was investigated using a gamma scintigraphic imaging method. The formulations contained paracetamol and samarium oxide (Sm 2 O 3) and either microcrystalline cellulose (MCC)
Autor:
Martti Marvola, Aapo Ahonen, Kai Lindevall, Mia Susanna Säkkinen, Janne Marvola, Hanna Kanerva
Publikováno v:
International Journal of Pharmaceutics. 307:285-291
Rapid passage through the proximal intestine can result in the low bioavailability of a drug substance with site-specific absorption characteristics in the upper gastrointestinal tract. To overcome this, there is increasing interest in developing gas
Autor:
Maija Lipponen, Lillian Slot, Sirpa Mykkänen, Kai Lindevall, Janne Marvola, Martti Marvola, Tommi Kekki, Kari Ariniemi, Hanna Kanerva, Heikki Hietanen
Publikováno v:
Marvola, J, Kanerva, H, Slot, L, Lipponen, M, Kekki, T, Hietanen, H, Mykkänen, S, Ariniemi, K, Lindevall, K & Marvola, M 2004, ' Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet ® constant-release drug delivery system ', International Journal of Pharmaceutics, vol. 281, no. 1-2, pp. 3-10 . https://doi.org/10.1016/j.ijpharm.2004.05.022
This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nucl
Autor:
Mia Susanna Säkkinen, Aapo Ahonen, Hanna Kanerva, Kai Lindevall, Janne Marvola, Martti Marvola
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 57:145-147
It is well known that adherence of a drug product, e.g. a gelatine capsule, to the oesophagus can cause oesophageal injury, which can be severe if the medicinal agent has corrosive properties. In a recent study we investigated by means of gamma scint
Publikováno v:
Drug development and industrial pharmacy. 36(6)
The computational models for predicting oral drug absorption in humans using in vitro and in vivo data have been published. However, only a limited number of studies are available on the prediction of local drug efficacy in the mouth using computatio
Publikováno v:
International journal of pharmaceutics. 307(2)
Rapid passage through the proximal intestine can result in the low bioavailability of a drug substance with site-specific absorption characteristics in the upper gastrointestinal tract. To overcome this, there is increasing interest in developing gas
Autor:
Mia Susanna Säkkinen, Martti Marvola, Aapo Ahonen, Hanna Kanerva, Kai Lindevall, Maija Lipponen, Janne Marvola, Tommi Kekki
Publikováno v:
Säkkinen, M, Marvola, J, Kanerva, H, Lindevall, M, Lipponen, M, Kekki, T, Ahonen, A & Marvola, M 2004, ' Gamma scintigraphic evaluation of the fate of microcrystalline chitosan granules in human stomach ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 1, pp. 133-143 . https://doi.org/10.1016/S0939-6411(03)00097-3
In several reports of in vitro studies it has been suggested that the mucoadhesive chitosans could be of value in preparing gastro-retentive formulations. The aim of this study was to obtain direct in vivo evidence of whether microcrystalline chitosa
Autor:
Kai Lindevall, Hanna Kanerva, Tommi Kekki, Outi Honkanen, Martti Marvola, Maija Lipponen, Janne Marvola, Aapo Ahonen
Publikováno v:
Honkanen, O, Marvola, J, Kanerva, H, Lindevall, K, Lipponen, M, Kekki, T, Ahonen, A & Marvola, M 2004, ' Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract ', European Journal of Pharmaceutical Sciences, vol. 21, no. 5, pp. 671-678 . https://doi.org/10.1016/j.ejps.2004.01.008
The fate (movement and disintegration) of hard novel hydroxypropyl methylcellulose (HPMC) two-piece capsules in the human gastrointestinal tract was investigated using a gamma scintigraphic imaging method. Two different prolonged-release formulations
Autor:
Outi, Honkanen, Pia, Laaksonen, Janne, Marvola, Sari, Eerikäinen, Raimo, Tuominen, Martti, Marvola, Laaksonen, Pia, Marvola, Janne, Eerikäinen, Sari, Tuominen, Raimo, Marvola, Martti
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 15(5)
The overall aim of the present study was to widen our knowledge about the biopharmaceutical behaviour of novel hydroxypropyl methylcellulose (HPMC)-based two-piece capsules by comparing them with the classic hard gelatine capsules. Firstly, the tende
Publikováno v:
European Journal of Pharmaceutical Sciences. 32:S7-S8