Výsledky vyhledávání - "Janne Mannila"

Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells

Autor: Ulrich Bergmann, Ari Tolonen, Markus Niemelä, Janne Mannila, Hanna-Marja Voipio, Sanna Turunen, Sakari Laaksonen, Maija Haj Hussain, Jere Huovinen, Petri Lehenkari, Toni Lassila, Johanna A. Huhtakangas, Juha Jyrkäs

Publikováno v: The Journal of steroid biochemistry and molecular biology. 188

Calcipotriol (MC903) is a side chain analogue of the biologically active 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Due to its anti-inflammatory and anti-proliferative effects on stromal cells, calcipotriol is a promising candidate for the local treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2fa2d289cb76bd8168897936180aad
https://pubmed.ncbi.nlm.nih.gov/30562554

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Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Autor: Josefina Santo Tomas, Christopher Snyder, Jessica Anne Steuten, Sergio Wittlin, Francis C. K. Chiu, Jacques Chollet, Xiaofang Wang, Kasiram Katneni, Yuxiang Dong, Eileen Ryan, Jonathan L. Vennerstrom, Susan A. Charman, Christian Scheurer, Julia Morizzi, Janne Mannila

Publikováno v: Journal of Medicinal Chemistry. 56:2547-2555

To ascertain the structure–activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we compared the antimalarial activities and ADME profiles of the 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ce32fde6bd7958f4aa225afbff7e39
https://doi.org/10.1021/jm400004u

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Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

Autor: Vesa-Pekka Lehto, Kristiina Järvinen, Pekka Jarho, Riikka Laitinen, Elina Turunen, Janne Mannila, Joakim Riikonen, Tomi Järvinen, Jarkko Ketolainen

Publikováno v: Journal of Pharmacy and Pharmacology. 63:19-25

Objectives The sublingual administration route as well as solid dispersion formation with macrogol 8000 and complexation with β-cyclodextrin (β-CyD) were investigated as ways for improving the absorption of perphenazine, a poorly water-soluble drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a260f5a4737c430f7dbd24d80d9e3418
https://doi.org/10.1111/j.2042-7158.2010.01173.x

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Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, α-cyclodextrin and quaternary chitosan N-betainate

Autor: Laura Matilainen, Seppo Auriola, Janne Mannila, Pekka Jarho, Jukka Holappa, Kristiina Järvinen

Publikováno v: International Journal of Pharmaceutics. 381:19-24

Systemic drug delivery through intraoral membranes may offer a promising administration route for lipophilic peptide drugs. The aim of the present study was to investigate the effect of alpha-cyclodextrin (alpha-CD) and a novel chitosan derivative, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17d7f4d215beed2adf72b0767cbf5b1
https://doi.org/10.1016/j.ijpharm.2009.07.012

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Sublingual administration of Δ9-tetrahydrocannabinol/β-cyclodextrin complex increases the bioavailability of Δ9-tetrahydrocannabinol in rabbits

Autor: Jussi Tervonen, Tomi Järvinen, Kristiina Järvinen, Janne Mannila, Pekka Jarho

Publikováno v: Life Sciences. 78:1911-1914

The bioavailability of Delta(9)-tetrahydrocannabinol (THC) was determined after its sublingual administration as solid THC/beta-cyclodextrin (THC/beta-CD) complex, and was compared to oral administration of ethanolic THC, in rabbits. The absolute bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7694ebaeb8632f6edb031d538a8acd1d
https://doi.org/10.1016/j.lfs.2005.08.025

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Effects of RM-β-CD on sublingual bioavailability of Δ9-tetrahydrocannabinol in rabbits

Autor: Maarit Tarvainen, Pekka Jarho, Kristiina Järvinen, Tomi Järvinen, Janne Mannila

Publikováno v: European Journal of Pharmaceutical Sciences. 26:71-77

The purpose of the present study was to develop novel cyclodextrin-containing sublingual formulations of cannabinoids. Complexation of model cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), with randomly methylated beta-cyclod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f9e2e94f20c6b7db1f24bbfd5f8207
https://doi.org/10.1016/j.ejps.2005.04.020

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Precipitation complexation method produces cannabidiol/beta-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol

Autor: Pekka Jarho, Tomi Järvinen, Kristiina Järvinen, Janne Mannila

Publikováno v: Journal of pharmaceutical sciences. 96(2)

In the present study, the precipitation complexation method was used to prepare a complex of cannabidiol (CBD) with beta-CD. The effect of beta-CD-complexation on the sublingual absorption of CBD was studied in rabbits. A solid CBD/beta-CD inclusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232eca6b0164c5177fbdfe7f95504b01
https://pubmed.ncbi.nlm.nih.gov/17051591

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Determination of Delta9-tetrahydrocannabinol from rabbit plasma by gas chromatography-mass spectrometry using two ionization techniques

Autor: Janne, Mannila, Marko, Lehtonen, Tomi, Järvinen, Pekka, Jarho

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 810(2)

The purpose of the study was to develop a gas chromatography-mass spectrometric (GC-MS) method for the identification and quantitation of Delta(9)-tetrahydrocannabinol (THC) in rabbit plasma. Two ionization techniques were utilized for GC-MS: electro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73f0c65210539f9ebdaa5b8b687041c6
https://pubmed.ncbi.nlm.nih.gov/15380726

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