Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma

Autor: Misba Khan, Md. Khirul Islam, Mafiur Rahman, Bert Dhondt, Ileana Quintero, Maija Puhka, Panu M. Jaakkola, Urpo Lamminmäki, Janne Leivo

Publikováno v: Nano Select, Vol 5, Iss 9, Pp n/a-n/a (2024)

Abstract Half of patients with renal cell carcinoma (RCC) develop metastases. New and noninvasive biomarkers are needed for the diagnosis of RCC. The study aims to develop an EV‐based assay for the detection of RCC using a highly sensitive nanopart

Externí odkaz: https://doaj.org/article/e55164b7822c462caf1219c44a7c0720

Integrins are enriched on aberrantly fucosylated tumour‐derived urinary extracellular vesicles

Autor: Md. Khirul Islam, Bert Dhondt, Parvez Syed, Misba Khan, Kamlesh Gidwani, Jason Webber, An Hendrix, Guido Jenster, Tarja Lamminen, Peter J. Boström, Kim Pettersson, Urpo Lamminmäki, Janne Leivo

Publikováno v: Journal of Extracellular Biology, Vol 1, Iss 10, Pp n/a-n/a (2022)

Abstract Urinary extracellular vesicles (uEVs) are enriched with glycosylated proteins which have been extensively studied as putative biomarkers of urological cancers. Here, we characterized the glycosylation and integrin profile of EVs derived from

Externí odkaz: https://doaj.org/article/1d91ebc06f174b25a384c8a485162385

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Autor: Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón‐Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. vanRoyen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert vanSteijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens‐Uzunova

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 7, Pp n/a-n/a (2021)

Abstract Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to

Externí odkaz: https://doaj.org/article/11056fe3164342fca660fd4db4496dcd

Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin

Autor: Sultana Akter, Teemu Kustila, Janne Leivo, Gangatharan Muralitharan, Markus Vehniäinen, Urpo Lamminmäki

Publikováno v: Biosensors, Vol 9, Iss 2, p 79 (2019)

Cyanobacterial blooms cause local and global health issues by contaminating surface waters. Microcystins and nodularins are cyclic cyanobacterial peptide toxins comprising numerous natural variants. Most of them are potent hepatotoxins, tumor promote

Externí odkaz: https://doaj.org/article/49349ac5952e4fc6a5676db66afb5b7d

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Autor: Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann, Jennifer Munkley

Publikováno v: Scott, E, Hodgson, K, Calle, B, Turner, H, Cheung, K, Bermudez, A, Marques, F J G, Pye, H, Yo, E C, Islam, K, Oo, H Z, McClurg, U L, Wilson, L, Thomas, H, Frame, F M, Orozco-Moreno, M, Bastian, K, Arredondo, H M, Roustan, C, Gray, M A, Kelly, L, Tolson, A, Mellor, E, Hysenaj, G, Goode, E A, Garnham, R, Duxfield, A, Heavey, S, Stopka-Farooqui, U, Haider, A, Freeman, A, Singh, S, Johnston, E W, Punwani, S, Knight, B, McCullagh, P, McGrath, J, Crundwell, M, Harries, L, Bogdan, D, Westaby, D, Fowler, G, Flohr, P, Yuan, W, Sharp, A, de Bono, J, Maitland, N J, Wisnovsky, S, Bertozzi, C R, Heer, R, Guerrero, R H, Daugaard, M, Leivo, J, Whitaker, H, Pitteri, S, Wang, N, Elliott, D J, Schumann, B & Munkley, J 2023, ' Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth ', Oncogene, vol. 42, pp. 926–937 . https://doi.org/10.1038/s41388-023-02604-x

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae09a3648b677fb4f00e9f89464d3260