Molecular mechanisms of thioridazine resistance in Staphylococcus aureus.

Autor: Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen, Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0201767 (2018)

Staphylococcus aureus has developed resistance towards the most commonly used anti-staphylococcal antibiotics. Therefore, there is an urgent need to find new treatment opportunities. A new approach relies on the use of helper compounds, which are abl

Externí odkaz: https://doaj.org/article/818ebccd8eec44a5b93f608b559486a9

The menaquinone pathway is important for susceptibility of Staphylococcus aureus to the antibiotic adjuvant, cannabidiol

Autor: Claes Søndergaard Wassmann, Andreas Pryds Rolsted, Mie Cecilie Lyngsie, Sergi Torres-Puig, Tina Kronborg, Martin Vestergaard, Hanne Ingmer, Steen Plesner Pontoppidan, Janne Kudsk Klitgaard

Publikováno v: Wassmann, C S, Rolsted, A P, Lyngsie, M C, Torres-Puig, S, Kronborg, T, Vestergaard, M, Ingmer, H, Pontoppidan, S P & Klitgaard, J K 2022, ' The menaquinone pathway is important for susceptibility of Staphylococcus aureus to the antibiotic adjuvant, cannabidiol ', Microbiological Research, vol. 257, 126974 . https://doi.org/10.1016/j.micres.2022.126974
Wassmann, C S, Rolsted, A P, Lyngsie, M C, Puig, S T, Kronborg, T, Vestergaard, M, Ingmer, H, Pontoppidan, S P & Klitgaard, J K 2022, ' The menaquinone pathway is important for susceptibility of Staphylococcus aureus to the antibiotic adjuvant, cannabidiol ', Microbiological Research, vol. 257, 126974 . https://doi.org/10.1016/j.micres.2022.126974

Emergence of antibiotic resistant bacteria is evolving at an alarming pace; therefore, we must start turning to alternative approaches. One of these, could be the use of antibiotic adjuvants that enhances the effect of antibiotics towards resistant b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b250c2fcbf9c732643b24a940e973c36
https://pubmed.ncbi.nlm.nih.gov/35091344

Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA

Autor: Noor Kelawi, Maria Pedersen, Mona Pedersen, Salli Nielsen, Louise N Hansen, Faidra Voukia, Jacob Kongsted, Carsten Uhd Nielsen, Brian N Andersen, Brian Urlund, Poul Nielsen, Peter Reinholdt, Stine H Sørensen, Janne Kudsk Klitgaard, Christoffer V Heidtmann

Publikováno v: Heidtmann, C V, Voukia, F, Hansen, L N, Sørensen, S H, Urlund, B, Nielsen, S, Pedersen, M, Kelawi, N, Andersen, B N, Pedersen, M, Reinholdt, P, Kongsted, J, Nielsen, C U, Klitgaard, J K & Nielsen, P 2020, ' Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA ', Journal of Medicinal Chemistry, vol. 63, no. 24, pp. 15693-15708 . https://doi.org/10.1021/acs.jmedchem.0c01328

Conjugation of pleuromutilin is an attractive strategy for the development of novel antibiotics and the fight against multiresistant bacteria as the class is associated with low rates of resistance and cross-resistance development. Herein, the prepar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c399c8d7d6ecbac554dfa56c8c5fa3b0
https://pubmed.ncbi.nlm.nih.gov/33325700

Co-release of dicloxacillin and thioridazine from catheter material containing an interpenetrating polymer network for inhibiting device-associated Staphylococcus aureus infection

Autor: Jes S. Lindholt, Rasmus Birkholm Grønnemose, Martin Alm, Kasper Klein, Thomas Emil Andersen, Michael Stenger, Janne Kudsk Klitgaard, Hans Jørn Kolmos, Peter T. Thomsen

Publikováno v: Stenger, M, Klein, K, Grønnemose, R B, Klitgaard, J K, Kolmos, H J, Lindholt, J S, Alm, M, Thomsen, P & Andersen, T E 2016, ' Co-release of dicloxacillin and thioridazine from catheter material containing an interpenetrating polymer network for inhibiting device-associated Staphylococcus aureus infection ', Journal of Controlled Release, vol. 241, pp. 125–134 . https://doi.org/10.1016/j.jconrel.2016.09.018

Approximately half of all nosocomial bloodstream infections are caused by bacterial colonization of vascular catheters. Attempts have been made to improve devices using anti-adhesive or antimicrobial coatings; however, it is often difficult to bind c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5fe0e1e459896d84d3423362e6e721
https://doi.org/10.1016/j.jconrel.2016.09.018

Studies of Impending Oligonucleotide Therapeutics in Simulated Biofluids

Autor: Lykke Haastrup Hansen, Maria Taskova, Kira Astakhova, Ivana Domljanovic, Anders Højgaard Hansen, Janne Kudsk Klitgaard

Publikováno v: Domljanovic, I, Hansen, A H, Hansen, L H, Klitgaard, J K, Taskova, M & Astakhova, K 2018, ' Studies of impending oligonucleotide therapeutics in simulated biofluids ', Nucleic Acid Therapeutics, vol. 28, no. 6, pp. 348-356 . https://doi.org/10.1089/nat.2017.0704

Synthetic oligonucleotides, their complexes and conjugates with other biomolecules represent valuable research tools and therapeutic agents. In spite of growing applications in basic research and clinical science, only few studies have addressed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a729ae5e97746987970a5234634f50c
https://pubmed.ncbi.nlm.nih.gov/30106665