Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Janne Kaskinoro"'
Autor:
Niina Jalava, Janne Kaskinoro, Hugh Chapman, Miguel Morales, Hanna Metsänkylä, Satu-Maarit Heinonen, Ari-Pekka Koivisto
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3350 (2023)
Transient receptor potential channels C4/C5 are widely expressed in the pain pathway. Here, we studied the putative analgesic efficacy of the highly selective and potent TRPC4/C5 antagonist HC-070 in rats. Inhibitory potency on human TRPC4 was assess
Externí odkaz:
https://doaj.org/article/225d91f559694aa19e93c68611dd103d
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79817adb5e1c73186ea6f167f3ba422
https://doi.org/10.1016/j.bmcl.2022.129005
https://doi.org/10.1016/j.bmcl.2022.129005
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c0582b9e57eabdf758db92785f82e
https://doi.org/10.1016/j.bmcl.2022.128783
https://doi.org/10.1016/j.bmcl.2022.128783
Autor:
Mira Lainiola, Katja Kuokkanen, Nelli Paasikoski, Mikko Myllymäki, Sanna K. Janhunen, Marja Vesajoki, Elena de Miguel, Olga Vekovischeva, Esa R. Korpi, Janne Kaskinoro, Anni-Maija Linden, Petri Hyytiä
Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39dbb5d6aef8a8893fde42bdc215fa9
http://hdl.handle.net/10138/323127
http://hdl.handle.net/10138/323127
Autor:
Elena, de Miguel, Olga, Vekovischeva, Katja, Kuokkanen, Marja, Vesajoki, Nelli, Paasikoski, Janne, Kaskinoro, Mikko, Myllymäki, Mira, Lainiola, Sanna K, Janhunen, Petri, Hyytiä, Anni-Maija, Linden, Esa R, Korpi
Publikováno v:
Addiction biologyREFERENCES. 24(6)
Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d256277e4d4c42de7ccaa96d2c124e60
https://pubmed.ncbi.nlm.nih.gov/30421860
https://pubmed.ncbi.nlm.nih.gov/30421860