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pro vyhledávání: '"Janna M Kozhekbaeva"'
Autor:
O. E. Fedorova, Raul C. Ribeiro, Elena Samochatova, Andrei S. Glotov, Victor Barsky, Natalia F. Krynetskaia, Janna M Kozhekbaeva, Olga A. Maiorova, Alexander V. Chudinov, Cheng Cheng, Anastasia E. Roudneva, Natalia V. Chupova, Tatyana V. Nasedkina, Valeria V Zemlyakova, Eugene Y Krynetskiy, Alexander G. Roumyantsev, Roman A Yurasov, William E. Evans, Alexander S. Zasedatelev
Publikováno v:
European Journal of Human Genetics. 14:991-998
Thiopurine drugs are metabolized, in part, by S-methylation catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low or undetectable TPMT activity are at high risk of severe, potentially fatal hematopoietic toxicity when they are tr