Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Janna, Minehart"'
Autor:
Scott A. Armstrong, Andrew L. Kung, James E. Bradner, Andrei V. Krivtsov, Jun Qi, Matthew Witkin, Janna Minehart, Sridhar Vempati, Tina Davis, Megan Bariteau, Wonil Kim, Matthew C. Stubbs
Supplementary Table S1-S3 Legends and Supplementary Figure S1-S6 Legends. Legends for supplementary tables S1-S3 and supplementary figures S1-S6 which support data in the manuscript, but could not be included due to space constraints.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3278aefd41ce661123c8d89f8a1fbe
https://doi.org/10.1158/1078-0432.22457502
https://doi.org/10.1158/1078-0432.22457502
Autor:
Scott A. Armstrong, Andrew L. Kung, James E. Bradner, Andrei V. Krivtsov, Jun Qi, Matthew Witkin, Janna Minehart, Sridhar Vempati, Tina Davis, Megan Bariteau, Wonil Kim, Matthew C. Stubbs
Purpose: Histone deacetylase inhibitors (HDACi) have recently emerged as efficacious therapies that target epigenetic mechanisms in hematologic malignancies. One such hematologic malignancy, B-cell acute lymphoblastic leukemia (B-ALL), may be highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23835c0d6e053bece84a8c34a9edfe1b
https://doi.org/10.1158/1078-0432.c.6523596
https://doi.org/10.1158/1078-0432.c.6523596
Autor:
Scott A. Armstrong, Andrew L. Kung, James E. Bradner, Andrei V. Krivtsov, Jun Qi, Matthew Witkin, Janna Minehart, Sridhar Vempati, Tina Davis, Megan Bariteau, Wonil Kim, Matthew C. Stubbs
Supplementary Tables S1-S3 and Supplementary Figures S1-S6. Table S1 - EC50 values for B-cell malignancies treated with HDAC inhibitors of varying isoform selectivity Table S2 - EC50 values for B-ALL cell line treated with a panel of HDAC inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7143001f9200b368a485c2b60c71fd9a
https://doi.org/10.1158/1078-0432.22457499
https://doi.org/10.1158/1078-0432.22457499
Autor:
Janna Minehart, Scott A. Armstrong, S. Haihua Chu, Evelyn J. Song, Andrei V. Krivtsov, Chloe N. Matovina, Richard Koche, Kenneth N. Ross, Elizabeth S. Frank, André Nussenzweig, Zhaohui Feng, Jessica L. Makofske, Jonathan Chabon, Haiming Xu
Publikováno v:
Blood Advances. 2:2478-2490
Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to progress for this patient population is the lack of immunocompetent models that faithfully recapit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0354765d51f996efa50a9ccb4050ff5
https://doi.org/10.1182/bloodadvances.2018021592
https://doi.org/10.1182/bloodadvances.2018021592
Autor:
S. Haihua Chu, X. Shirley Liu, Jayanta Chaudhuri, Putzer J Hung, André Nussenzweig, Jian Zhang, Zhaohui Feng, Richard Koche, Bo-Ruei Chen, Elsa Callen, Yijun Xiong, Janna Minehart, Barry P. Sleckman, Vipul Kumar, Scott A. Armstrong, Chloe N. Matovina, Jonathan Chabon
Publikováno v:
iScience
iScience, Vol 23, Iss 3, Pp-(2020)
iScience, Vol 23, Iss 3, Pp-(2020)
Summary Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1c417edfd171b9f5660dc3aa4d39ae
https://pubmed.ncbi.nlm.nih.gov/32169821
https://pubmed.ncbi.nlm.nih.gov/32169821
Autor:
Jamie L. Bessich, Daniel H. Sterman, M. A.Curotto de Lafaille, Daniel Katzman, Vivek Murthy, Keshav Mangalick, Jun Chieh J. Tsay, Janna Minehart, Chandra Goparaju, Harvey I. Pass, Gaetane Michaud, Samaan Rafeq
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 137
Objectives Tumor draining lymph nodes (TDLN) are key sites of early immunoediting in patients with non-small cell lung cancer (NSCLC) and play an important role in generating anti-tumor immunity. Immune suppression in the tumor microenvironment has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd70a37a38d11d6a07a98f91938c59e
https://pubmed.ncbi.nlm.nih.gov/31563736
https://pubmed.ncbi.nlm.nih.gov/31563736
Autor:
S. Haihua Chu, Joshua DeJong, Chun-Wei Chen, Janna Minehart, Haiming Xu, Richard Koche, Amit U. Sinha, Benjamin L. Ebert, Scott A. Armstrong, Rowena Eng, Noushin F. Rahnamay, Fatima Al-Shahrour, Robert G. Roeder, Aniruddha J. Deshpande, Mo Chen, Nan Zhu
Publikováno v:
Journal of Clinical Investigation. 126:997-1011
Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecb575fc29002da6a95c59ed30f1bf5
https://doi.org/10.1172/jci82978
https://doi.org/10.1172/jci82978
Autor:
S Haihua, Chu, Evelyn J, Song, Jonathan R, Chabon, Janna, Minehart, Chloe N, Matovina, Jessica L, Makofske, Elizabeth S, Frank, Kenneth, Ross, Richard P, Koche, Zhaohui, Feng, Haiming, Xu, Andrei, Krivtsov, Andre, Nussenzweig, Scott A, Armstrong
Publikováno v:
Blood advances. 2(19)
Mll-Af4 and mutant N-Ras cooperate to generate an aggressive B-acute lymphoblastic leukemia murine model, recapitulating human disease.Combination MEK and ATR inhibitor treatment of Mll-Af4/N-Ras leukemia induces synergistic antileukemic effects in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2544b87cb03c7910c2cd57ffafaafe
https://pubmed.ncbi.nlm.nih.gov/30266823
https://pubmed.ncbi.nlm.nih.gov/30266823
Publikováno v:
Journal of the National Cancer Institute. 109(12)
Modern cancer immunotherapies represent a major shift in paradigm with respect to how we understand innate and adaptive responses to malignancy. Successful tumors co-opt normal immunosurveillance mechanisms by potent interactions between the tumor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54881f7db34dc9a29a47ce49b77c44c
https://pubmed.ncbi.nlm.nih.gov/30053078
https://pubmed.ncbi.nlm.nih.gov/30053078
Autor:
Chloe N. Matovina, Jonathan Chabon, Zhaohui Feng, Putzer J Hung, Jian Zhang, Janna Minehart, Scott A. Armstrong, Barry P. Sleckman, S. Haihua Chu, Jayanta Chaudhuri, Bo-Ruei Chen, Richard Koche, X. Shirley Liu, André Nussenzweig, Elsa Callen-Moreu
Publikováno v:
Blood. 132:511-511
Rearrangement of the immunoglobulin heavy chain locus (IgH) through non-homologous end-joining (NHEJ)-mediated VDJ recombination is a requisite step in normal lymphocyte development. This process is initiated through cleavage of DNA by RAG1/2 recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff0c587fa459fdb00e0755745e51278
https://doi.org/10.1182/blood-2018-99-111952
https://doi.org/10.1182/blood-2018-99-111952