Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jann Sarkaria"'
Autor:
Andrew Takchi, Minzhi Zhang, Mohammad Jalalirad, Roberto Leon Ferre, Royal Shrestha, Tufia Haddad, Jann Sarkaria, Ann Tuma, Jodi Carter, Hillman David, Karthik Giridhar, Liewei Wang, Carol Lange, Urban Lendahl, James Ingle, Matthew Goetz, Antonino Bonaventura D’Assoro
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Triple negative breast cancer (TNBC) accounts for 15–20% of all breast cancers and mainly affects pre-menopausal and minority women. Because of the lack of ER, PR or HER2 expression in TNBC, there are limited options for tailored therapies. While T
Externí odkaz:
https://doaj.org/article/ef71d4b2bfbb4846b7a7d75ed4097563
Autor:
Jenifer Pendiuk Goncalves, Sierra A. Walker, Jesús S. Aguilar Díaz de león, Yubo Yang, Irina Davidovich, Sara Busatto, Jann Sarkaria, Yeshayahu Talmon, Chad R. Borges, Joy Wolfram
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8506 (2023)
Extracellular vesicles (EVs) play important roles in (patho)physiological processes by mediating cell communication. Although EVs contain glycans and glycosaminoglycans (GAGs), these biomolecules have been overlooked due to technical challenges in co
Externí odkaz:
https://doaj.org/article/c5ea95134109479f883f45aaa57ba5f6
Autor:
Sara Busatto, Yubo Yang, Sierra A. Walker, Irina Davidovich, Wan-Hsin Lin, Laura Lewis-Tuffin, Panagiotis Z. Anastasiadis, Jann Sarkaria, Yeshayahu Talmon, Gregory Wurtz, Joy Wolfram
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro-metastatic EVs that travel in the circulation to distant orga
Externí odkaz:
https://doaj.org/article/c8aeaedf15fd41f4ae7bd55884e1084f
Autor:
Priscilla K. Brastianos, Erin L. Twohy, Elizabeth R. Gerstner, Timothy J. Kaufmann, A. John Iafrate, Jochen Lennerz, Suriya Jeyapalan, David E. Piccioni, Varun Monga, Camilo E. Fadul, David Schiff, Jennie W. Taylor, Sajeel A. Chowdhary, Chetan Bettegowda, George Ansstas, Macarena De La Fuente, Mark D. Anderson, Nicole Shonka, Denise Damek, Jose Carrillo, Lara J. Kunschner-Ronan, Rekha Chaudhary, Kurt A. Jaeckle, Francis M. Senecal, Thomas Kaley, Tara Morrison, Alissa A. Thomas, Mary R. Welch, Fabio Iwamoto, David Cachia, Adam L. Cohen, Shivangi Vora, Michael Knopp, Ian F. Dunn, Priya Kumthekar, Jann Sarkaria, Susan Geyer, Xiomara W. Carrero, Maria Martinez-Lage, Daniel P. Cahill, Paul D. Brown, Caterina Giannini, Sandro Santagata, Frederick G. Barker, Evanthia Galanis
Publikováno v:
Journal of Clinical Oncology. 41:618-628
PURPOSE Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship with NF2 loss. Given the predominance of NF2 mutations in meningiomas, we eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d92dd4797c6a215de625e0d33d141d
https://doi.org/10.1200/jco.21.02371
https://doi.org/10.1200/jco.21.02371
Autor:
Kshama Gupta, Ivan Vuckovic, Song Zhang, Yuning Xiong, Brett L. Carlson, Joshua Jacobs, Ian Olson, Xuan-Mai Petterson, Slobodan I. Macura, Jann Sarkaria, Terry C. Burns
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Glioblastoma (GBM) is uniformly fatal with a 1-year median survival, despite best available treatment, including radiotherapy (RT). Impacts of prior RT on tumor recurrence are poorly understood but may increase tumor aggressiveness. Metabolic changes
Externí odkaz:
https://doaj.org/article/7930d328fe63410ca2add16c7b58b4d7
Autor:
Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad, Matthew Goetz, Judy Boughey, Jann Sarkaria, Liewei Wang, James N. Ingle, Evanthia Galanis, Antonino B. D’Assoro
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-19 (2018)
Abstract Background Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. NOTCH developmental
Externí odkaz:
https://doaj.org/article/86a3724d1a17429ca5f5edb8bc06a69b
Autor:
Priscilla K, Brastianos, Erin L, Twohy, Elizabeth R, Gerstner, Timothy J, Kaufmann, A John, Iafrate, Jochen, Lennerz, Suriya, Jeyapalan, David E, Piccioni, Varun, Monga, Camilo E, Fadul, David, Schiff, Jennie W, Taylor, Sajeel A, Chowdhary, Chetan, Bettegowda, George, Ansstas, Macarena, De La Fuente, Mark D, Anderson, Nicole, Shonka, Denise, Damek, Jose, Carrillo, Lara J, Kunschner-Ronan, Rekha, Chaudhary, Kurt A, Jaeckle, Francis M, Senecal, Thomas, Kaley, Tara, Morrison, Alissa A, Thomas, Mary R, Welch, Fabio, Iwamoto, David, Cachia, Adam L, Cohen, Shivangi, Vora, Michael, Knopp, Ian F, Dunn, Priya, Kumthekar, Jann, Sarkaria, Susan, Geyer, Xiomara W, Carrero, Maria, Martinez-Lage, Daniel P, Cahill, Paul D, Brown, Caterina, Giannini, Sandro, Santagata, Frederick G, Barker, Evanthia, Galanis
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
Patients with progressive or recurrent meningiomas have limited systemic therapy options. Focal adhesion kinase (FAK) inhibition has a synthetic lethal relationship withEligible patients whose tumors screened positively forOf 322 patients screened fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15320c49eedc56725b5f7b9cc65c4517
https://pubmed.ncbi.nlm.nih.gov/36288512
https://pubmed.ncbi.nlm.nih.gov/36288512
Autor:
Valerie DeLuca, Nanyun Tang, Yue Hao, Anjali Raju, Charles Shaffer, Cecile Riviere-Cazaux, Terry C. Burns, Jann Sarkaria, Ian Parney, Patrick Pirrotte, Kendall Van Keuren-Jensen, Michael E. Berens
Publikováno v:
Cancer Research. 83:2788-2788
Glioblastoma (GBM), a lethal astrocytic brain tumor, has limited available treatment options. A major hindrance to the progress of new therapies is the selectivity of the blood brain barrier (BBB) which limits drug access to the tumor. Further, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2229efe99b36987ac8187639782452
https://doi.org/10.1158/1538-7445.am2023-2788
https://doi.org/10.1158/1538-7445.am2023-2788
Publikováno v:
Neuro-Oncology. 24:vii218-vii219
INTRODUCTION Glioblastoma (GBM) is the most common and aggressive form of adult brain tumor and is an incurable disease due to primary and secondary resistance to therapy. We recently examined the candidate genes modulating temozolomide (TMZ) resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605367dea1316c126c1e44edd2a6ff91
https://doi.org/10.1093/neuonc/noac209.841
https://doi.org/10.1093/neuonc/noac209.841
Autor:
Leland S Hu, Shuluo Ning, Jennifer M Eschbacher, Nathan Gaw, Amylou C Dueck, Kris A Smith, Peter Nakaji, Jonathan Plasencia, Sara Ranjbar, Stephen J Price, Nhan Tran, Joseph Loftus, Robert Jenkins, Brian P O'Neill, William Elmquist, Leslie C Baxter, Fei Gao, David Frakes, John P Karis, Christine Zwart, Kristin R Swanson, Jann Sarkaria, Teresa Wu, J Ross Mitchell, Jing Li
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141506 (2015)
Genetic profiling represents the future of neuro-oncology but suffers from inadequate biopsies in heterogeneous tumors like Glioblastoma (GBM). Contrast-enhanced MRI (CE-MRI) targets enhancing core (ENH) but yields adequate tumor in only ~60% of case
Externí odkaz:
https://doaj.org/article/320cfd61fa854bedb91d16d8e4075cd4