Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Janis Lem"'
Autor:
Clint L Makino, Xiao-Hong Wen, Norman A Michaud, Henry I Covington, Emmanuele DiBenedetto, Heidi E Hamm, Janis Lem, Giovanni Caruso
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37832 (2012)
The retinal rod outer segment is a sensory cilium that is specialized for the conversion of light into an electrical signal. Within the cilium, up to several thousand membranous disks contain as many as a billion copies of rhodopsin for efficient pho
Externí odkaz:
https://doaj.org/article/0d4762ef52cd437f881928ddb98c56ca
Autor:
Alexis-Pierre Bemelmans, Corinne Kostic, Sylvain V Crippa, William W Hauswirth, Janis Lem, Francis L Munier, Mathias W Seeliger, Andreas Wenzel, Yvan Arsenijevic
Publikováno v:
PLoS Medicine, Vol 3, Iss 10, p e347 (2006)
BackgroundRPE65 is specifically expressed in the retinal pigment epithelium and is essential for the recycling of 11-cis-retinal, the chromophore of rod and cone opsins. In humans, mutations in RPE65 lead to Leber congenital amaurosis or early-onset
Externí odkaz:
https://doaj.org/article/d501fbaec73c460a990cff0d73a84c2f
Autor:
Muhammad M. Abd-El-Barr, Debra E. Bramblett, Eric M. Lo, David L. Paul, Janis Lem, David L. Simons, Samuel M. Wu, Cameron S. Cowan, Meike E van der Heijden
Publikováno v:
Vision Research. 119:99-109
Rod pathways are a parallel set of synaptic connections which enable night vision by relaying and processing rod photoreceptor light responses. We use dim light stimuli to isolate rod pathway contributions to downstream light responses then character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1f8e016ff49e78c1afbce1d942810b
https://doi.org/10.1016/j.visres.2015.11.006
https://doi.org/10.1016/j.visres.2015.11.006
Autor:
Adrienne Gentry, Jessica K. Paulus, Janis Lem, Larry A. Feig, Kelly Pagidas, Virginia Mensah, Lorena Saavedra-Rodriguez, David A. Dickson
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Translational Psychiatry, Vol 8, Iss 1, Pp 1-10 (2018)
Exposure of male mice to early life stress alters the levels of specific sperm miRNAs that promote stress-associated behaviors in their offspring. To begin to evaluate whether similar phenomena occur in men, we searched for sperm miRNA changes that o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d7982e6de7696ac29ffb423e8548d9
http://europepmc.org/articles/PMC5966454
http://europepmc.org/articles/PMC5966454
Autor:
Russell G. Foster, Mark W. Hankins, Martin Biel, Stewart Thompson, King Wai Yau, Franz Hofmann, Nicholas Mrosovsky, Samer Hattar, Ronald H. Douglas, Janis Lem, Robert J. Lucas
In the mammalian retina, besides the conventional rod–cone system, a melanopsin-associated photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c9dd8bfe592fc0bbf8b79176819d6
https://ora.ox.ac.uk/objects/uuid:d6189682-0bdb-4e72-b24b-635951cf30ba
https://ora.ox.ac.uk/objects/uuid:d6189682-0bdb-4e72-b24b-635951cf30ba
Autor:
Krzysztof Palczewski, Paul S.-H. Park, Kiichiro Okano, Rosalie K. Crouch, Tadao Maeda, Akiko Maeda, Janis Lem
Publikováno v:
Proceedings of the National Academy of Sciences. 107:8428-8433
S-palmitoylation is a conserved feature in many G protein–coupled receptors (GPCRs) involved in a broad array of signaling processes. The prototypical GPCR, rhodopsin, is S-palmitoylated on two adjacent C-terminal Cys residues at its cytoplasmic su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3121cf6cd6a114ffb04e88ae0b2f07
https://doi.org/10.1073/pnas.1000640107
https://doi.org/10.1073/pnas.1000640107
Publikováno v:
Proceedings of the National Academy of Sciences. 107:395-400
Bipolar cells are the central neurons of the retina that transmit visual signals from rod and cone photoreceptors to third-order neurons in the inner retina and the brain. A dogma set forth by early anatomical studies is that bipolar cells in mammali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4257a7d4447589d67a9b815bc7dfb7
https://doi.org/10.1073/pnas.0907178107
https://doi.org/10.1073/pnas.0907178107
Autor:
Tadao Maeda, Daniel J. Müller, Krzysztof Palczewski, K. Tanuj Sapra, Paul S.-H. Park, Janis Lem, Slawomir Filipek, Beata Jastrzebska, Wojciech Pulawski, Akiko Maeda, Masahiro Kono, Rosalie K. Crouch
Publikováno v:
Biochemistry. 48:4294-4304
Rhodopsin is palmitylated at two cysteine residues in its carboxyl terminal region. We have looked at the effects of palmitylation on the molecular interactions formed by rhodopsin using single-molecule force spectroscopy and the function of rhodopsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3fd4d6ddcdb941ba6cff1eafa789cb
https://doi.org/10.1021/bi900417b
https://doi.org/10.1021/bi900417b
Autor:
Emmanuele DiBenedetto, Heidi E. Hamm, Vsevolod V. Gurevich, Muayyad R. Al-Ubaidi, Robert E. Anderson, Norman Michaud, Lixin Shen, Xiao-Hong Wen, Richard S. Brush, Clint L. Makino, Janis Lem
Publikováno v:
Biophysical Journal. 96:939-950
Rhodopsins are densely packed in rod outer-segment membranes to maximize photon absorption, but this arrangement interferes with transducin activation by restricting the mobility of both proteins. We attempted to explore this phenomenon in transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571f55f04f2354eb1b2f6be21c697a1d
https://doi.org/10.1016/j.bpj.2008.10.016
https://doi.org/10.1016/j.bpj.2008.10.016
Autor:
Nikolai O. Artemyev, Marie E. Burns, Ching-Kang Chen, James B. Hurley, Janis Lem, Rebecca Reh, Desheng Chen, Vasily Kerov, Mustapha Moussaif, W.W. Rubin
Publikováno v:
Journal of Neuroscience. 26:6863-6872
The Nougaret form of dominant stationary night blindness is linked to a G38D mutation in the rod transducin-alpha subunit (Talpha). In this study, we have examined the mechanism of Nougaret night blindness using transgenic mice expressing TalphaG38D.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c24d86ea87dcfab0605c0f2cc9f98ee
https://doi.org/10.1523/jneurosci.1322-06.2006
https://doi.org/10.1523/jneurosci.1322-06.2006