Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Janis L. Hammett"'
Autor:
Neville F. Ford, Neil R. Johnston, Neeraj Dhaun, David J. Webb, Maria Palmisano, David E. Newby, Janis L. Hammett, Fiona E. Strachan
Publikováno v:
British Journal of Clinical Pharmacology. 60:611-622
Aims A number of endothelin receptor antagonists (ERAs) are currently in clinical development as potential therapies in states characterized by vasoconstriction, such as systemic hypertension. We investigated the haemodynamic effects of locally and s
Publikováno v:
Current Therapeutic Research. 62:699-708
Background: Behavioral evidence from animal studies has suggested that ceronapril and other angiotensin-converting enzyme (ACE) inhibitors have some anxiolytic activity. Objectives: The objectives of this trial were to assess the effects of ceronapri
Publikováno v:
The Journal of Clinical Pharmacology. 38:1116-1121
A double-blind, placebo-controlled, parallel-group, ascending, multiple-dose study was completed in 45 healthy male volunteers to assess the maximum tolerated dose, pharmacokinetics, and pharmacodynamics of BMS-187745, a squalene synthase inhibitor,
Publikováno v:
Pharmaceutical Research. 15:1782-1786
Purpose. To estimate and compare the oral bioavailability of a drug (BMS-187745) administered as single doses of oral solution of either the parent drug or its prodrug (BMS-188494). Methods. A single-dose, two-period, three-treatment, control-balance
Autor:
Ralph H. Raymond, Janis L. Hammett, Domenic A. Sica, Peter H. Slugg, Todd W.B. Gehr, Neville F. Ford
Publikováno v:
European Journal of Clinical Pharmacology. 53:117-121
Objective: The single-dose and steady-state pharmacokinetics of the HMG CoA reductase inhibitor pravastatin and its two metabolites, SQ 31 906 and SQ 31 945, were evaluated in 12 hemodialysis patients. A single 20-mg i.v. dose was employed, followed
Autor:
Ralph H. Raymond, Neville F. Ford, Hester Tr, Janis L. Hammett, Turnbull D, Gale Pj, Frankos Vh, Cohen Mb
Publikováno v:
Plastic and Reconstructive Surgery. 100:1291-1298
The objective of this matched case-control study was to determine whether women with Même or Replicon polyurethane-covered silicone breast implants are exposed to clinically significant levels of free 2,4-TDA from biodegradation of the polyurethane
Autor:
Howard D. Uderman, Janis L. Hammett, Kathleen M. Langenbacher, Maria R. Marino, Peter Nichola
Publikováno v:
Journal of Clinical Psychopharmacology. 17:27-33
The effect of nefazodone on the pharmacokinetics of a single dose of phenytoin was evaluated in 18 healthy male subjects. The subjects received a single oral dose of phenytoin, 300 mg, on day 1 of the study and the pharmacokinetic profile of the drug
Autor:
Neeraj, Dhaun, Fiona E, Strachan, David E, Newby, Neil R, Johnston, Neville F, Ford, Janis L, Hammett, Maria, Palmisano, David J, Webb
Publikováno v:
British journal of clinical pharmacology. 60(6)
A number of endothelin receptor antagonists (ERAs) are currently in clinical development as potential therapies in states characterized by vasoconstriction, such as systemic hypertension. We investigated the haemodynamic effects of locally and system
Autor:
Wei‐chi Liao, Ole Vesterqvist, James A. Manning, H. Wayne Hutman, Kathy D. Davis, Alan Meier, Janis L. Hammett, Irene Ferreira
Publikováno v:
The American journal of geriatric cardiology. 10(1)
Omapatrilat is the most clinically advanced member of a new class of cardiovascular drugs, vasopeptidase inhibitors. Omapatrilat is a single molecule that simultaneously inhibits neutral endopeptidase and angiotensin-converting enzyme, thus preservin
Autor:
Ralph H. Raymond, Neville F. Ford, Janis L. Hammett, James Manning, Donald R. Van Harken, Kenneth C. Lasseter
Publikováno v:
Journal of clinical pharmacology. 35(2)
The single-dose and steady-state pharmacokinetics of the angiotensin-converting enzyme (ACE) inhibitor fosinopril and its active diacid, fosinoprilat, were evaluated in 6 healthy volunteers and 12 patients with alcoholic cirrhosis. Fosinopril was adm