Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Janis K Burkhardt"'
Autor:
Katherine S Forsyth, Nathan H Roy, Elise Peauroi, Brian C DeHaven, Erik D Wold, Adam R Hersperger, Janis K Burkhardt, Laurence C Eisenlohr
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008685 (2020)
Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the cause of mousepox. Disease severity is linked to an array of immunomodulatory proteins includi
Externí odkaz:
https://doaj.org/article/cbe58d5655a243ab9ea7b8e6f10f1425
Publikováno v:
eLife, Vol 9 (2020)
T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting antigen-presenting cell. During an immune response, DCs undergo a maturation proces
Externí odkaz:
https://doaj.org/article/c2970352579946319bfe16a53cf24405
Publikováno v:
eLife, Vol 5 (2016)
T cell receptor (TCR) engagement opens Ca2+ release-activated Ca2+ (CRAC) channels and triggers formation of an immune synapse between T cells and antigen-presenting cells. At the synapse, actin reorganizes into a concentric lamellipod and lamella wi
Externí odkaz:
https://doaj.org/article/5dd68499391f412b8f89333305f092c1
Autor:
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin
Publikováno v:
eLife, Vol 4 (2015)
Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation.
Externí odkaz:
https://doaj.org/article/f960d6f2019e4067b92e0cb40238c62c
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133353 (2015)
Functionally diverse CD8+ T cells develop in response to antigenic stimulation with differing capacities to couple TCR engagement to downstream signals and functions. However, mechanisms of diversifying TCR signaling are largely uncharacterized. Here
Externí odkaz:
https://doaj.org/article/eb16aa0b364c41498823d614287b14e3
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e52368 (2013)
T cell trafficking between the blood and lymphoid organs is a complex, multistep process that requires several highly dynamic and coordinated changes in cyto-architecture. Members of the ezrin, radixin and moesin (ERM) family of actin-binding protein
Externí odkaz:
https://doaj.org/article/cbe6690c1ec2488aba8ccdffea9e2e47
Autor:
Chih-Jung Hsu, Wan-Ting Hsieh, Abraham Waldman, Fiona Clarke, Eric S Huseby, Janis K Burkhardt, Tobias Baumgart
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32398 (2012)
T cell receptor (TCR) engagement induces clustering and recruitment to the plasma membrane of many signaling molecules, including the protein tyrosine kinase zeta-chain associated protein of 70 kDa (ZAP70) and the adaptor SH2 domain-containing leukoc
Externí odkaz:
https://doaj.org/article/edccc69f4b924fafbd5f0502f0b1c261
Autor:
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45276 (2012)
The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1,
Externí odkaz:
https://doaj.org/article/5159c08438b74cfcb4ab902da3231388
Autor:
Meredith H Shaffer, Yanping Huang, Evann Corbo, Gregory F Wu, Marielena Velez, John K Choi, Ichiko Saotome, Judy L Cannon, Andrea I McClatchey, Anne I Sperling, Jonathan S Maltzman, Paula M Oliver, Avinash Bhandoola, Terri M Laufer, Janis K Burkhardt
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12404 (2010)
Ezrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling and pol
Externí odkaz:
https://doaj.org/article/56ce580815234058a88d288fe69bec5a
Autor:
Daniela Gómez Atria, Brian T. Gaudette, Jennifer Londregan, Samantha Kelly, Eric Perkey, Anneka Allman, Bhaskar Srivastava, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Russell J.H. Ryan, Tanner F. Robertson, Janis K. Burkhardt, Warren S. Pear, David Allman, Ivan Maillard
Publikováno v:
Journal of Clinical Investigation. 132
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting the homeostatic proliferation of mature lymphocytes. The molecular mechanisms underlying these responses and their functional conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d7cb0fd05337af277f20468ab3528c
https://doi.org/10.1172/jci158885
https://doi.org/10.1172/jci158885