Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Janis J. Weis"'
Autor:
Sergio A. Hernández, Katarina Ogrinc, Miša Korva, Andrej Kastrin, Petra Bogovič, Tereza Rojko, Keith W. Kelley, Janis J. Weis, Franc Strle, Klemen Strle
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 6, Pp 1091-1101 (2023)
Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and
Externí odkaz:
https://doaj.org/article/4ffc9c3c8ef34effa218f0f7b8bb57cb
Publikováno v:
BioTechniques, Vol 52, Iss 3, Pp 183-190 (2012)
Congenic mapping is a powerful strategy to identify genomic loci regulating quantitative traits. Generating congenic lines is an iterative process of refinement that is both time and resource intensive. Here we report an alternative to traditional mi
Externí odkaz:
https://doaj.org/article/44c737e1ead84f9a86ed7cdc4b120e03
Autor:
Jinze Li, Ying Ma, Jackie K Paquette, Amanda C Richards, Matthew A Mulvey, James F Zachary, Cory Teuscher, Janis J Weis
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010365 (2022)
Type I interferon (IFN) has been identified in patients with Lyme disease, and its abundant expression in joint tissues of C3H mice precedes development of Lyme arthritis. Forward genetics using C3H mice with severe Lyme arthritis and C57BL/6 (B6) mi
Externí odkaz:
https://doaj.org/article/cc570cec88f04bf799a5cd5ef361dbf4
Publikováno v:
Nat Rev Rheumatol
Infectious agents can trigger autoimmune responses in a number of chronic inflammatory diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia burgdorferi, is effectively treated in most patients with antibiotic therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812b77c571625636301ca4cae511dc97
https://doi.org/10.1038/s41584-021-00648-5
https://doi.org/10.1038/s41584-021-00648-5
Autor:
Jinze Li, Ying Ma, Jackie K. Paquette, Amanda C. Richards, Matthew A. Mulvey, James F. Zachary, Cory Teuscher, Janis J. Weis
Publikováno v:
PLoS pathogens. 18(3)
Type I interferon (IFN) has been identified in patients with Lyme disease, and its abundant expression in joint tissues of C3H mice precedes development of Lyme arthritis. Forward genetics using C3H mice with severe Lyme arthritis and C57BL/6 (B6) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a0fb3a41951dfae0b1ae8e635975a3
https://pubmed.ncbi.nlm.nih.gov/35324997
https://pubmed.ncbi.nlm.nih.gov/35324997
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123218 (2015)
The IfitmDel mouse lacks all five of the Ifitm genes via LoxP deletion. This animal breeds normally with no obvious defect in development. The IfitmDel animals exhibit a steady and significantly enhanced weight gain relative to wild-type controls beg
Externí odkaz:
https://doaj.org/article/7395adf61e844165ac1bae2b274981aa
Autor:
Robert B Lochhead, James F Zachary, Luciana Dalla Rosa, Ying Ma, John H Weis, Ryan M O'Connell, Janis J Weis
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135142 (2015)
MicroRNA-155 has been shown to play a role in immune activation and inflammation, and is suppressed by IL-10, an important anti-inflammatory cytokine. The established involvement of IL-10 in the murine model of Borrelia burgdorferi-induced Lyme arthr
Externí odkaz:
https://doaj.org/article/e5ea112f0ccb4c0fae54a3c86d09dce9
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 4 (2014)
Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a
Externí odkaz:
https://doaj.org/article/086f714cd5a8429da00617796f2c874b
Autor:
Robert B Lochhead, Ying Ma, James F Zachary, David Baltimore, Jimmy L Zhao, John H Weis, Ryan M O'Connell, Janis J Weis
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004212 (2014)
MicroRNAs have been shown to be important regulators of inflammatory and immune responses and are implicated in several immune disorders including systemic lupus erythematosus and rheumatoid arthritis, but their role in Lyme borreliosis remains unkno
Externí odkaz:
https://doaj.org/article/0e38995a17b74823a99f730f607094b6
Publikováno v:
Trends in Immunology. 39:1021-1035
T cell responses are essential for appropriate protection against pathogens. T cell immunity is achieved through the ability to discriminate between foreign and self-molecules, and this relies heavily on stringent T cell receptor (TCR) specificity. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a892beaa8cf963259cdf37543d2bdb
https://doi.org/10.1016/j.it.2018.10.003
https://doi.org/10.1016/j.it.2018.10.003