Zobrazeno 1 - 10
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pro vyhledávání: '"Janis E. Lochner"'
Autor:
Janis E. Lochner
Publikováno v:
The FASEB Journal. 33
Macromolecular structure, interactions and dynamics are essential underpinnings of an education in biochemistry. Biochemists often convey these core concepts by systematically probing the structure...
Publikováno v:
The FASEB Journal. 29
N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are the universal molecular machinery used to mediate membrane fusion events. Syntaxins are SNARE proteins that reside in the target membrane and determine the allowable s
Autor:
Scooter D. Johnson, Meredith Farmer, Dmitri Gurkins, Patrizia Rosa, Michael A. Silverman, Bethe A. Scalettar, Janis E. Lochner
Publikováno v:
The Journal of Neuroscience. 25:3095-3106
Dense-core granules (DCGs) are organelles found in specialized secretory cells, including neuroendocrine cells and neurons. Neuronal DCGs facilitate many critical processes, including the transport and secretion of proteins involved in learning, and
Publikováno v:
Journal of Visualized Experiments.
Detection of fluorescence provides the foundation for many widely utilized and rapidly advancing microscopy techniques employed in modern biological and medical applications. Strengths of fluorescence include its sensitivity, specificity, and compati
Publikováno v:
Molecular Biology of the Cell. 9:2463-2476
A hybrid protein, tPA/GFP, consisting of rat tissue plasminogen activator (tPA) and green fluorescent protein (GFP) was expressed in PC12 cells and used to study the distribution, secretory behavior, and dynamics of secretory granules containing tPA
Publikováno v:
Journal of Biological Chemistry. 270:9106-9114
Stromelysin-1 (ST-1) is an extracellular matrix metalloproteinase whose expression is transcriptionally regulated by nerve growth factor (NGF) in the PC12 rat pheochromocytoma cell line. In this paper, we define sequences in the proximal ST-1 promote
Publikováno v:
Molecular and Cellular Neuroscience. 6:56-68
Matrix metalloproteinases have been implicated in various extracellular matrix remodeling events that occur during normal development and in a number of pathologies. In previous work with PC12 rat pheochromocytoma cells, we found that the matrix meta
Autor:
Bethe A. Scalettar, A. Simon, Conor Jacobs, Janis E. Lochner, A. Fulwiler, Louis S. Prahl, L. Hilken
Publikováno v:
Developmental neurobiology. 72(9)
Dense-core granules (DCGs) are organelles found in neuroendocrine cells and neurons that house, transport, and release a number of important peptides and proteins. In neurons, DCG cargo can include the secreted neuromodulatory proteins tissue plasmin
Autor:
Kevin McAllister, M. Chavarha, E. Spangler, L.C. Schuttner, Conor Jacobs, Bethe A. Scalettar, Janis E. Lochner
Publikováno v:
Developmental neurobiology. 68(10)
Recent data suggest that tissue plasminogen activator (tPA) influences long-term plasticity at hippocampal synapses by converting plasminogen into plasmin, which then generates mature brain-derived neurotrophic factor (mBDNF) from its precursor, proB
Publikováno v:
The FASEB Journal. 22