Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Janis C. Weeks"'
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 174-187 (2021)
Currently, only a few chemical drug classes are available to control the global burden of nematode infections in humans and animals. Most of these drugs exert their anthelmintic activity by interacting with proteins such as ion channels, and the nema
Externí odkaz:
https://doaj.org/article/77eee454a84a41f4a97ae760c2019425
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 607-628 (2018)
Many anthelmintic drugs used to treat parasitic nematode infections target proteins that regulate electrical activity of neurons and muscles: ion channels (ICs) and neurotransmitter receptors (NTRs). Perturbation of IC/NTR function disrupts worm beha
Externí odkaz:
https://doaj.org/article/286a466f2263460fb3293d93f3cfe018
Autor:
Janis C. Weeks, William M. Roberts, Kristin J. Robinson, Melissa Keaney, Jon J. Vermeire, Joseph F. Urban Jr., Shawn R. Lockery, John M. Hawdon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 314-328 (2016)
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device (‘chip’) that r
Externí odkaz:
https://doaj.org/article/9f476598198d4afa81ee0b1d6df29faa
Autor:
Ryan Choi, Samantha A. Michaels, Emmanuel C. Onu, Matthew A. Hulverson, Aparajita Saha, Morenike E. Coker, Janis C. Weeks, Wesley C. Van Voorhis, Kayode K. Ojo
Publikováno v:
Molecules, Vol 25, Iss 12, p 2773 (2020)
Transmission of human malaria parasites (Plasmodium spp.) by Anopheles mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four
Externí odkaz:
https://doaj.org/article/536274f939304bdbab45b7bfee39c93a
Autor:
Matthew A. Hulverson, Aparajita Saha, Emmanuel C Onu, Kayode K. Ojo, Ryan Choi, Janis C. Weeks, Morenike E Coker, Samantha A. Michaels, Wesley C. Van Voorhis
Publikováno v:
Molecules
Molecules, Vol 25, Iss 2773, p 2773 (2020)
Molecules, Vol 25, Iss 2773, p 2773 (2020)
Transmission of human malaria parasites (Plasmodium spp.) by Anopheles mosquitoes is a continuous process that presents a formidable challenge for effective control of the disease. Infectious gametocytes continue to circulate in humans for up to four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316c5754cd60c609aeee425f2511cdc8
https://pubmed.ncbi.nlm.nih.gov/32560085
https://pubmed.ncbi.nlm.nih.gov/32560085
Autor:
Kristin J. Robinson, Shawn R. Lockery, William M. Roberts, Janis C. Weeks, Jon J. Vermeire, Melissa Keaney, Joseph F. Urban, John M. Hawdon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 314-328 (2016)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device (‘chip’) that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efdd5c5cde688f83469ae5132fd56a7
http://www.sciencedirect.com/science/article/pii/S2211320716300458
http://www.sciencedirect.com/science/article/pii/S2211320716300458
Autor:
Janis C. Weeks
Publikováno v:
Progress in Neurobiology. 70:421-442
Steroid hormones act via evolutionarily conserved nuclear receptors to regulate neuronal phenotype during development, maturity and disease. Steroid hormones exert 'global' effects in organisms to produce coordinated physiological responses whereas,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2f6dc2e2e87157d9dff664205b22b8
https://doi.org/10.1016/s0301-0082(03)00102-3
https://doi.org/10.1016/s0301-0082(03)00102-3
Publikováno v:
The Journal of Comparative Neurology. 457:384-403
Neuronal death occurs during normal development and disease and can be regulated by steroid hormones. In the hawkmoth, Manduca sexta, individual accessory planta retractor (APR) motoneurons undergo a segment-specific pattern of programmed cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbbf45d11f2d7fb6e0b551c52c6b7a1
https://doi.org/10.1002/cne.10563
https://doi.org/10.1002/cne.10563
Autor:
Kurt L. Hoffman, Janis C. Weeks
Publikováno v:
Developmental Biology. 229:517-536
Accessory planta retractor (APR) motoneurons of the hawk moth, Manduca sexta, undergo a segment-specific pattern of programmed cell death (PCD) 24 to 48 h after pupal ecdysis (PE). Cell culture experiments show that the PCD of APRs in abdominal segme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80d68ddd3a8f6a8251ab727ed24527f
https://doi.org/10.1006/dbio.2000.9987
https://doi.org/10.1006/dbio.2000.9987
Autor:
A. Novicki, Janis C. Weeks
Publikováno v:
Journal of Comparative Physiology A: Sensory, Neural, and Behavioral Physiology. 186:69-79
Each molt in the hawkmoth, Manduca sexta, culminates in the shedding of the old cuticle at ecdysis. Prior to each larval ecdysis, the old cuticle is loosened by pre-ecdysis behavior, which includes rhythmic, synchronous compressions in all abdominal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c947e8213e911156cbf8aa8072d9e66c
https://doi.org/10.1007/s003590050008
https://doi.org/10.1007/s003590050008