Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Janine T Erler"'
Autor:
Eli Elyas, Alex Grimwood, Janine T Erler, Simon P Robinson, Thomas R Cox, Daniel Woods, Peter Clowes, Ramona De Luca, Franco Marinozzi, Jérémie Fromageau, Jeffrey C Bamber
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169664 (2017)
Elastography, the imaging of elastic properties of soft tissues, is well developed for macroscopic clinical imaging of soft tissues and can provide useful information about various pathological processes which is complementary to that provided by the
Externí odkaz:
https://doaj.org/article/cfa61d5543f2418eafc5686def10eb19
Autor:
Clara Mayer, Lluís Riera-Ponsati, Sakari Kauppinen, Henrik Klitgaard, Janine T. Erler, Stine N. Hansen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodegenerative diseases constitute a global health issue and a major economic burden. They significantly impair both cognitive and motor functions, and their prevalence is expected to rise due to ageing societies and continuous population growth.
Externí odkaz:
https://doaj.org/article/ed186951ce8645ee905a86c980cc5ef6
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Metastatic complications are responsible for more than 90% of cancer related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multi-step process, with each step involving intricate cross-talk between the cancer c
Externí odkaz:
https://doaj.org/article/1f56d21dce5145a7ab070bfd74d0b995
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129470 (2015)
Gene expression and functional studies have indicated that the molecular programmes involved in prostate development are also active in prostate cancer. PTEN has been implicated in human prostate cancer and is frequently mutated in this disease. Here
Externí odkaz:
https://doaj.org/article/965f1e7366f14f7bb43f42183a8e6726
Autor:
Kasper J. Mygind, Denise Nikodemus, Sebastian Gnosa, Ramya Kweder, Nicolai J. Wewer Albrechtsen, Marie Kveiborg, Janine T. Erler, Reidar Albrechtsen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5871 (2024)
Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.
Externí odkaz:
https://doaj.org/article/825f5f9180ec45d2a84117c4c5f040ba
Autor:
Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla W. Zornhagen, Jan E. Strøbech, Lutz Fleischhauer, Alejandro E. Mayorca-Guiliani, Sebastian R. Nielsen, Dina S. Grønseth, Filip Kuś, Erwin M. Schoof, Luis Arnes, Manuel Koch, Hauke Clausen-Schaumann, Valerio Izzi, Raphael Reuten, Janine T. Erler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as such plays
Externí odkaz:
https://doaj.org/article/1b359b8013e44394a924f6031f8d7cb2
Autor:
Jan E. Strøbech, Pietro Giuriatti, Rikke Stagaard, Paulo De Sepulveda, Sebastian R. Nielsen, Janine T. Erler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Patients with pancreatic ductal adenocarcinoma (PDAC) have a dismal 5-year survival rate of less than 10%, predominantly due to delayed diagnosis and a lack of effective treatment options. In the PDAC tumor microenvironment (TME), neutrophils are amo
Externí odkaz:
https://doaj.org/article/52604e17191a4993b5ac038c3904f7b0
PDF file - 911K, S2: Inhibition of LOXL2 in 4T1 CM reduces fibroblast branching on collagen and collagen contraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14e15dbac0e1f329758d67a0f44450a
https://doi.org/10.1158/1541-7786.22510128
https://doi.org/10.1158/1541-7786.22510128
Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell–derived lysyl oxidase-like 2 (LOXL2) significantly inhibited mammary tumor cell invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5411db0de9738aa5d47fa2a52c84b5fc
https://doi.org/10.1158/1541-7786.c.6539517.v1
https://doi.org/10.1158/1541-7786.c.6539517.v1
PDF file - 82K, S1: 4T1 shLOXL2 CM has lower levels of LOXL2 protein and activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce5c12704fc80200e37359be000c0b2
https://doi.org/10.1158/1541-7786.22510131.v1
https://doi.org/10.1158/1541-7786.22510131.v1