Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Janine Suffner"'
Autor:
Günter J. Hämmerling, Kristin Hochweller, Natalio Garbi, Guido H. Wabnitz, Janine Suffner, Yvonne Samstag
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5931-5936
Dendritic cells (DCs) are key components of the adaptive immune system contributing to initiation and regulation of T cell responses. T cells continuously scan DCs in lymphoid organs for the presence of foreign antigen. However, little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f615e7782c14b8ee7eda71077f7ced
https://doi.org/10.1073/pnas.0911877107
https://doi.org/10.1073/pnas.0911877107
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 188(3)
Bone marrow-derived dendritic cell (DC) precursors seed peripheral organs, where they encounter diverse cellular environments during their final differentiation into DCs. Flt3 ligand (Flt3-L) is critical for instructing DC generation throughout diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5678819c37f69c3aba1bfa0c877423c0
https://pubmed.ncbi.nlm.nih.gov/22198954
https://pubmed.ncbi.nlm.nih.gov/22198954
Autor:
Lisa Föhse, Reinhold Förster, Chun Wei Lee, Christian Koenecke, Jan D. Haas, Karsten Suhre, André Bleich, Cornelia Lindner, Bernard Malissen, Sebastian Suerbaum, Immo Prinz, Benjamin Wahl, Günter J. Hämmerling, Janine Suffner, Stella Lamprecht, Susanne Schmitz
Publikováno v:
Eur. J. Immunol. 41, 3101-3113 (2011)
European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
European Journal of Immunology, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
European Journal of Immunology, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
International audience; Dominant tolerance to self-antigen requires the presence of sufficient numbers of CD4(+) Foxp3(+) Treg cells with matching antigen specificity. However, the size and role of TCR repertoire diversity for antigen-specific immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006e6a498c195afe171583d470f18f27
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6917
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6917
Autor:
Günter J. Hämmerling, Melanie D. Leech, Stephen M. Anderton, Richard A. O’Connor, Janine Suffner
Publikováno v:
O'Connor, R A, Leech, M D, Suffner, J, Haemmerling, G J & Anderton, S M 2010, ' Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo ', Journal of Immunology, vol. 185, no. 12, pp. 7235-7243 . https://doi.org/10.4049/jimmunol.1001551
Interest in the use of regulatory T cells (Tregs) as cellular therapeutics has been tempered by reports of naturally occurring Tregs losing Foxp3 expression and producing IL-17, raising concerns over a switch to pathogenic function under inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0edfee3456209ff4fadd4a1c5a75e5
https://pubmed.ncbi.nlm.nih.gov/21084662
https://pubmed.ncbi.nlm.nih.gov/21084662
Publikováno v:
European journal of immunology. 40(12)
There are a number of factors that hamper immunotherapy of cancer. For example, tumors exhibit an aberrant vasculature that appears to form a barrier against T-cell infiltration. Another major obstacle is created by Treg. So far, conventional depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911db342334bb1e8d28238b1f2b23080
https://pubmed.ncbi.nlm.nih.gov/21072887
https://pubmed.ncbi.nlm.nih.gov/21072887
Autor:
Janine Suffner, Xingrui Li, Richard A. Kroczek, Kristin Hochweller, Günter J. Hämmerling, Natalio Garbi, Marie Kühnle
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 184(4)
Foxp3+CD4+ regulatory T cells (Tregs) are crucial in maintaining self-tolerance and limiting immune responses to pathogens. Shifting the sensitive balance between Tregs and effector T cells requires extensive knowledge of the homeostatic properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3940b51fa8d6a7cd6dbb6bc264d27d42
https://pubmed.ncbi.nlm.nih.gov/20083650
https://pubmed.ncbi.nlm.nih.gov/20083650